Patents by Inventor James W. Hillendahl
James W. Hillendahl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230204497Abstract: This relates to systems and methods for measuring a concentration and type of substance in a sample at a sampling interface. The systems can include a light source, optics, one or more modulators, a reference, a detector, and a controller. The systems and methods disclosed can be capable of accounting for drift originating from the light source, one or more optics, and the detector by sharing one or more components between different measurement light paths. Additionally, the systems can be capable of differentiating between different types of drift and eliminating erroneous measurements due to stray light with the placement of one or more modulators between the light source and the sample or reference. Furthermore, the systems can be capable of detecting the substance along various locations and depths within the sample by mapping a detector pixel and a microoptics to the location and depth in the sample.Type: ApplicationFiled: February 20, 2023Publication date: June 29, 2023Inventors: Miikka M. Kangas, Mark Alan Arbore, David I. Simon, Michael J. Bishop, James W. Hillendahl, Robert Chen
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Patent number: 11585749Abstract: This relates to systems and methods for measuring a concentration and type of substance in a sample at a sampling interface. The systems can include a light source, optics, one or more modulators, a reference, a detector, and a controller. The systems and methods disclosed can be capable of accounting for drift originating from the light source, one or more optics, and the detector by sharing one or more components between different measurement light paths. Additionally, the systems can be capable of differentiating between different types of drift and eliminating erroneous measurements due to stray light with the placement of one or more modulators between the light source and the sample or reference. Furthermore, the systems can be capable of detecting the substance along various locations and depths within the sample by mapping a detector pixel and a microoptics to the location and depth in the sample.Type: GrantFiled: October 5, 2020Date of Patent: February 21, 2023Assignee: Apple Inc.Inventors: Miikka M. Kangas, Mark Alan Arbore, David I. Simon, Michael J. Bishop, James W. Hillendahl, Robert Chen
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Publication number: 20210018432Abstract: This relates to systems and methods for measuring a concentration and type of substance in a sample at a sampling interface. The systems can include a light source, optics, one or more modulators, a reference, a detector, and a controller. The systems and methods disclosed can be capable of accounting for drift originating from the light source, one or more optics, and the detector by sharing one or more components between different measurement light paths. Additionally, the systems can be capable of differentiating between different types of drift and eliminating erroneous measurements due to stray light with the placement of one or more modulators between the light source and the sample or reference. Furthermore, the systems can be capable of detecting the substance along various locations and depths within the sample by mapping a detector pixel and a microoptics to the location and depth in the sample.Type: ApplicationFiled: October 5, 2020Publication date: January 21, 2021Inventors: Miikka M. Kangas, Mark Alan Arbore, David I. Simon, Michael J. Bishop, James W. Hillendahl, Robert Chen
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Patent number: 10801950Abstract: This relates to systems and methods for measuring a concentration and type of substance in a sample at a sampling interface. The systems can include a light source, optics, one or more modulators, a reference, a detector, and a controller. The systems and methods disclosed can be capable of accounting for drift originating from the light source, one or more optics, and the detector by sharing one or more components between different measurement light paths. Additionally, the systems can be capable of differentiating between different types of drift and eliminating erroneous measurements due to stray light with the placement of one or more modulators between the light source and the sample or reference. Furthermore, the systems can be capable of detecting the substance along various locations and depths within the sample by mapping a detector pixel and a microoptics to the location and depth in the sample.Type: GrantFiled: August 29, 2016Date of Patent: October 13, 2020Assignee: Apple Inc.Inventors: Miikka M. Kangas, Mark Alan Arbore, David I. Simon, Michael J. Bishop, James W. Hillendahl, Robert Chen
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Publication number: 20190094069Abstract: An electronic device may be provided with a display. An opaque layer may be formed on an inner surface of a display cover layer in an inactive area of the display. An optical component window may be formed from the opening. A light guide may be aligned with the optical component window and may be used to guide light from the optical component window to an optical component such as an ambient light sensor. The light guide may have a core surrounded by a cladding. The core may be formed from a material such as blue glass that absorbs infrared light and that transmits visible light. Particles of titanium dioxide or other high-refractive-index material may be incorporated into the core to enhance the refractive index of the core. Thin-film interference filters may be formed on the light guide to enhance infrared light blocking.Type: ApplicationFiled: July 18, 2018Publication date: March 28, 2019Inventors: Tingjun Xu, Avery P. Yuen, James W. Hillendahl, Ligang Wang, Ove Lyngnes, Sunggu Kang, Xianwei Zhao, Xingxing Cai
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Publication number: 20180238794Abstract: This relates to systems and methods for measuring a concentration and type of substance in a sample at a sampling interface. The systems can include a light source, optics, one or more modulators, a reference, a detector, and a controller. The systems and methods disclosed can be capable of accounting for drift originating from the light source, one or more optics, and the detector by sharing one or more components between different measurement light paths. Additionally, the systems can be capable of differentiating between different types of drift and eliminating erroneous measurements due to stray light with the placement of one or more modulators between the light source and the sample or reference. Furthermore, the systems can be capable of detecting the substance along various locations and depths within the sample by mapping a detector pixel and a microoptics to the location and depth in the sample.Type: ApplicationFiled: August 29, 2016Publication date: August 23, 2018Inventors: Miikka M. KANGAS, Mark Alan ARBORE, David I. SIMON, Michael J. BISHOP, James W. HILLENDAHL, Robert CHEN
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Patent number: 8985808Abstract: A planar sample, particularly of the type used in biological laboratories for detection and sometimes analysis of two-dimensional arrays of proteins, nucleic acids, or other biological species, is illuminated by epi-illumination using optically filtered line lights that are arranged along opposing parallel sides of a rectangle in which the sample array resides, with two coaxial line lights on each side of the rectangle, and the two on any given side being separated by a gap whose optimal width depends on the wavelength band transmitted by the optical filter. Surprisingly, the gap eliminates the peak in intensity at the center of the sample area and the decrease that occurs from the center outward that would otherwise occur with a single continuous filtered line light, producing instead a substantially uniform intensity along the direction parallel to the line lights.Type: GrantFiled: January 14, 2013Date of Patent: March 24, 2015Assignee: Bio-Rad Laboratories, Inc.Inventors: James W. Hillendahl, Evelio Perez
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Patent number: 8743367Abstract: An SPR or other optical resonance based analysis system in which, light is provided at multiple angles to a specimen and then the light modified by the specimen is processed to select only some of the light. Optionally, the processing selects light at a particular incidence angle. Optionally, the detection is by imaging of the light on a 2D imager array.Type: GrantFiled: May 21, 2008Date of Patent: June 3, 2014Assignee: Bio-Rad Laboratories Inc.Inventors: Boaz Ran, Tal Rosenzweig, Ariel G. Notcovich, Ariel Shemesh, Yochanan Uri, Michael Kanevsky, James W. Hillendahl, Barak Abraham Liraz
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Publication number: 20100220330Abstract: An SPR or other optical resonance based analysis system in which, light is provided at multiple angles to a specimen and then the light modified by the specimen is processed to select only some of the light. Optionally, the processing selects light at a particular incidence angle. Optionally, the detection is by imaging of the light on a 2D imager array.Type: ApplicationFiled: May 21, 2008Publication date: September 2, 2010Applicant: Bio-Rad Laboratories Inc.Inventors: Boaz Ran, Tal Rosenzweig, Ariel G. Notcovich, Ariel Shemesh, Yochanan Uri, Michael Kanevsky, James W. Hillendahl, Barak Abraham Liraz
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Patent number: 7376304Abstract: Biochemical assays of samples in receptacles, in gels, in blots, in arrays and the like, and that utilize excitation and light emission as labels for detection are enhanced by an illumination and detection system that supplies excitation light through an optical fiber that transmits excitation light from an excitation light source to the sample. Emission light produced by the excitation is then collected by a lens and converted to a signal that is compiled by conventional software for analysis. The optical fiber transfixes (passes through) the lens via a slot or other opening and is preferably offset from the center of the lens. The optical fiber and collecting lens can either be on the same side of the sample or on opposite sides, i.e., one above and the other below.Type: GrantFiled: September 14, 2006Date of Patent: May 20, 2008Assignee: Bio-Rad Laboratories, Inc.Inventors: James W. Hillendahl, David E. Waldbeser
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Patent number: 7310462Abstract: Biochemical assays that are performed in cuvettes and in the wells of multi-well plates and that utilize excitation and light emission as labels for detection are enhanced by an illumination and detection system that supplies excitation light through an optical fiber that transmits excitation light from an excitation light source to the cuvette or well. Emission light produced by the excitation is then collected by a collimating lens and converted to a signal that is compiled by conventional software for analysis. The optical fiber and collimating lens can either be on the same side of the receptacle (generally the open side) or on opposite sides, i.e., one above and the other below.Type: GrantFiled: October 18, 2006Date of Patent: December 18, 2007Assignee: Bio-Rad Laboratories, Inc.Inventors: James W. Hillendahl, David E. Waldbeser
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Patent number: 7218810Abstract: Biochemical assays that are performed in cuvettes and in the wells of multi-well plates and that utilize excitation and light emission as labels for detection are enhanced by an illumination and detection system that supplies excitation light through an optical fiber that transmits excitation light from an excitation light source to the cuvette or well. Emission light produced by the excitation is then collected by a collimating lens and converted to a signal that is compiled by conventional software for analysis. The optical fiber and collimating lens can either be on the same side of the receptacle (generally the open side) or on opposite sides, i.e., one above and the other below.Type: GrantFiled: September 19, 2002Date of Patent: May 15, 2007Assignee: Bio-Rad Laboratories, Inc.Inventors: James W. Hillendahl, David E. Waldbeser
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Patent number: 6754414Abstract: Microarrays are imaged by an illumination and detection system that supplies excitation light through one or more optical fibers, each fiber transmitting excitation light from an excitation light source to a single spot in the microarray. Emission light from each spot is then collected by a collimating lens and converted to a signal that is compiled by conventional software into an image of the entire microarray. The optical fiber(s) and the collimating lens are arranged such that the direction of travel of the excitation light and the direction along which the emission light is collected are not coaxial, and preferably both are at an acute angle to the axis normal to the plane of the microarray.Type: GrantFiled: September 19, 2002Date of Patent: June 22, 2004Assignee: Bio-Rad Laboratories, Inc.Inventors: Harry R. Naghieh, James W. Hillendahl, David E. Waldbeser
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Publication number: 20030128910Abstract: Microarrays are imaged by an illumination and detection system that supplies excitation light through one or more optical fibers, each fiber transmitting excitation light from an excitation light source to a single spot in the microarray. Emission light from each spot is then collected by a collimating lens and converted to a signal that is compiled by conventional software into an image of the entire microarray. The optical fiber(s) and the collimating lens are arranged such that the direction of travel of the excitation light and the direction along which the emission light is collected are not coaxial, and preferably both are at an acute angle to the axis normal to the plane of the microarray.Type: ApplicationFiled: September 19, 2002Publication date: July 10, 2003Applicant: BIO-RAD LABORATORIES, INC.Inventors: Harry R. Naghieh, James W. Hillendahl, David E. Waldbeser
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Publication number: 20030063851Abstract: Biochemical assays that are performed in cuvettes and in the wells of multi-well plates and that utilize excitation and light emission as labels for detection are enhanced by an illumination and detection system that supplies excitation light through an optical fiber that transmits excitation light from an excitation light source to the cuvette or well. Emission light produced by the excitation is then collected by a collimating lens and converted to a signal that is compiled by conventional software for analysis. The optical fiber and collimating lens can either be on the same side of the receptacle (generally the open side) or on opposite sides, i.e., one above and the other below.Type: ApplicationFiled: September 19, 2002Publication date: April 3, 2003Applicant: BIO-RAD LABORATORIES, INC.Inventors: James W. Hillendahl, David E. Waldbeser, Harry R. Naghieh
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Patent number: 5171411Abstract: Alloys useful for preparing self-supporting cylindrical targets are provided. The alloys comprise zinc and one or more other metals chosen from the following: aluminum, bismuth, cerium, gadolinium, hafnium, niobium, silicon, tantalum, titanium, vanadium, yttrium, and zirconium. In one preferred embodiment, a zinc alloy with approximately 2% aluminum forms self-supporting cylindrical targets from which metal oxide films are prepared by reactive sputtering. The alloy oxide films are clear, transparent, non-absorbing, and optically functional.Type: GrantFiled: May 21, 1991Date of Patent: December 15, 1992Assignee: The BOC Group, Inc.Inventors: James W. Hillendahl, J. Glen Palmer