Patents by Inventor James W. Janetka

James W. Janetka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and methods for treating bacterial infections
    Patent number: 11773127
    Abstract: The present invention is directed to various compounds, compositions, and methods for treating bacterial infections such as urinary tract infections.
    Type: Grant
    Filed: November 8, 2018
    Date of Patent: October 3, 2023
    Assignee: Washington University
    Inventors: Vasilios Kalas, James W. Janetka, Scott Hultgren, Jerry Pinkner, Amarendar Maddirala, Vishnu Damalanka
  • COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS
    Publication number: 20230033327
    Abstract: The present invention encompasses compounds and methods for treating and preventing bacterial infections specifically urinary tract infections and those caused by bacteria containing type 1 pili and FimH. The present invention also encompasses compounds and methods for treating inflammatory bowel disease specifically Crohn's Disease.
    Type: Application
    Filed: August 26, 2022
    Publication date: February 2, 2023
    Inventors: James W. JANETKA, Zhenfu HAN, Scott HULTGREN, Jerry PINKER, CORINNE CUSUMANO
  • CDPK1 inhibitors, compositions, and methods related thereto
    Patent number: 11518761
    Abstract: The invention relates to inhibitors of calcium-dependent protein kinase 1 (CDPK1) and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T. gondii, P. falciparum, C. hominis, or C. parvum infections, using the novel inhibitors of the invention.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: December 6, 2022
    Assignees: Vyera Pharmaceuticals, LLC, Washington University
    Inventors: Allen T. Hopper, L. David Sibley, James W. Janetka, Jon Helander
  • COMPOUNDS AND METHODS FOR TREATING CANCER, VIRAL INFECTIONS, AND ALLERGIC CONDITIONS
    Publication number: 20220380407
    Abstract: The present invention generally relates to compounds that are useful for inhibiting one or more trypsin-like S1 serine proteases, HGFA, matriptase, hepsin, KLK5 and/or TMPRSS2 as well as cysteine proteases including trypsin-like cysteine proteases (e.g. Cathepsin B). The present invention also relates to various methods of using the inhibitor compounds to treat or prevent viral infections, including those caused by coronaviruses and influenza, conditions associated with KLK5, various malignancies, pre-malignant conditions, and cancer.
    Type: Application
    Filed: June 25, 2020
    Publication date: December 1, 2022
    Applicant: Washington University
    Inventors: James W. Janetka, Vishnu Damalanka
  • MANNOSE-DERIVED ANTAGONISTS OF FIMH USEFUL FOR TREATING DISEASE
    Publication number: 20220235087
    Abstract: The present invention relates to mannoside derivative compounds useful as inhibitors of FimH and methods for the treatment or prevention of urinary tract infection.
    Type: Application
    Filed: April 6, 2022
    Publication date: July 28, 2022
    Inventors: James W. JANETKA, Laurel MYDOCK-MCGRANE
  • INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES
    Publication number: 20220169676
    Abstract: The present invention generally relates to compounds that are useful for inhibiting one or more of hepatocyte growth factor activator, matriptase, hepsin, Factor Xa, or thrombin. The present invention also relates to various methods of using the inhibitor compounds including treating a malignancy, a pre-malignant condition, or cancer by administering an effective amount of the inhibitor to a subject in need thereof.
    Type: Application
    Filed: September 14, 2021
    Publication date: June 2, 2022
    Applicant: Washington University
    Inventors: James W. Janetka, Zhenfu Han, Peter Harris, Partha Karmakar
  • Compositions and methods for treating parasitic diseases
    Patent number: 11208411
    Abstract: Disclosed herein, inter alia, are compositions and methods for treating parasitic diseases.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: December 28, 2021
    Assignees: The Regents of the University of California, Washington University
    Inventors: Florentine Rutaganira, Kevan M. Shokat, Laurence David Sibley, James W. Janetka
  • CDPK1 INHIBITORS, COMPOSITIONS, AND METHODS RELATED THERETO
    Publication number: 20210347780
    Abstract: The invention relates to inhibitors of calcium-dependent protein kinase 1 (CDPK1) and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T. gondii, P. falciparum, C. hominis, or C. parvum infections, using the novel inhibitors of the invention.
    Type: Application
    Filed: September 19, 2019
    Publication date: November 11, 2021
    Inventors: Allen T. HOPPER, L. David SIBLEY, James W. JANETKA
  • Inhibitors of growth factor activation enzymes
    Patent number: 11130780
    Abstract: The present invention generally relates to compounds that are useful for inhibiting one or more of hepatocyte growth factor activator, matriptase, hepsin, Factor Xa, or thrombin. The present invention also relates to various methods of using the inhibitor compounds including treating a malignancy, a pre-malignant condition, or cancer by administering an effective amount of the inhibitor to a subject in need thereof.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: September 28, 2021
    Assignee: Washington University
    Inventors: James W. Janetka, Zhenfu Han, Peter Harris, Partha Karmakar
  • COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS
    Publication number: 20210171563
    Abstract: The present invention is directed to various compounds, compositions, and methods for treating bacterial infections such as urinary tract infections.
    Type: Application
    Filed: November 8, 2018
    Publication date: June 10, 2021
    Applicant: Washington University
    Inventors: Vasilios Kalas, James W. Janetka, Scott Hultgren, Jerry Pinkner, Amarendar Maddirala, Vishnu Damalanka
  • COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS
    Publication number: 20210122776
    Abstract: The present invention encompasses compounds and methods for treating and preventing bacterial infections specifically urinary tract infections and those caused by bacteria containing type 1 pili and FimH. The present invention also encompasses compounds and methods for treating inflammatory bowel disease specifically Crohn's Disease.
    Type: Application
    Filed: December 28, 2020
    Publication date: April 29, 2021
    Inventors: James W. Janetka, Zhenfu Han, Scott Hultgren, Jerry Pinkner, Corinne Cusumano
  • CDPK1 INHIBITORS, COMPOSITIONS, AND METHODS RELATED THERETO
    Publication number: 20210032240
    Abstract: The invention relates to inhibitors of calcium-dependent protein kinase 1 (CDPK1) and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T. gondii, P. falciparum, C. hominis, or C. parvum infections, using the novel inhibitors of the invention.
    Type: Application
    Filed: August 17, 2018
    Publication date: February 4, 2021
    Inventors: Allen T. Hopper, L. David Sibley, James W. Janetka, Jon Helander
  • MANNOSE-DERIVED ANTAGONISTS OF FIMH USEFUL FOR TREATING DISEASE
    Publication number: 20200407390
    Abstract: The present invention relates to mannoside derivative compounds useful as inhibitors of FimH and methods for the treatment or prevention of urinary tract infection.
    Type: Application
    Filed: July 10, 2020
    Publication date: December 31, 2020
    Inventors: James W. JANETKA, Laurel MYDOCK-MCGRANE
  • COMPOSITIONS AND METHODS FOR TREATING PARASITIC DISEASES
    Publication number: 20200291030
    Abstract: Disclosed herein, inter alia, are compositions and methods for treating parasitic diseases.
    Type: Application
    Filed: March 17, 2017
    Publication date: September 17, 2020
    Inventors: Florentine Rutaganira, Kevan M. Shokat, Laurence David Sibley, James W. Janetka
  • Mannose-derived antagonists of FimH useful for treating disease
    Patent number: 10738070
    Abstract: The present invention relates to mannoside derivative compounds useful as inhibitors of FimH and methods for the treatment or prevention of urinary tract infection.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: August 11, 2020
    Assignee: Fimbrion Therapeutics, Inc.
    Inventors: James W. Janetka, Laurel Mydock-McGrane
  • C-GLYCOSIDE COMPOUNDS USEFUL FOR TREATING DISEASE
    Publication number: 20200002303
    Abstract: The present invention relates to mannoside derivative compounds useful as inhibitors of FimH and methods for the treatment or prevention of urinary tract infection.
    Type: Application
    Filed: March 11, 2017
    Publication date: January 2, 2020
    Inventors: James W. JANETKA, Laurel MYDOCK-MCGRANE
  • COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS
    Publication number: 20190211045
    Abstract: The present invention encompasses compounds and methods for treating urinary tract infections.
    Type: Application
    Filed: March 14, 2019
    Publication date: July 11, 2019
    Inventors: James W. Janetka, Zhenfu Han, Scott Hultgren, Jerome S. Pinkner, Corinne Cusumano
  • Compounds and methods for treating bacterial infections
    Patent number: 10273260
    Abstract: The present invention encompasses compounds and methods for treating urinary tract infections.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: April 30, 2019
    Assignee: WASHINGTON UNIVERSITY
    Inventors: James W. Janetka, Zhenfu Han, Scott Hultgren, Jerome S. Pinkner, Corinne Cusumano
  • MANNOSE-DERIVED ANTAGONISTS OF FIMH USEFUL FOR TREATING DISEASE
    Publication number: 20190106451
    Abstract: The present invention relates to mannoside derivative compounds useful as inhibitors of FimH and methods for the treatment or prevention of urinary tract infection.
    Type: Application
    Filed: March 23, 2017
    Publication date: April 11, 2019
    Inventors: James W. JANETKA, Laurel MYDOCK-MCGRANE
  • COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS
    Publication number: 20180194792
    Abstract: The present invention encompasses compounds and methods for treating and preventing bacterial infections specifically urinary tract infections and those caused by bacteria containing type 1 pili and FimH. The present invention also encompasses compounds and methods for treating inflammatory bowel disease specifically Crohn's Disease.
    Type: Application
    Filed: March 8, 2018
    Publication date: July 12, 2018
    Inventors: James W. Janetka, Zhenfu Han, Scott Hultgren, Jerry Pinkner, Corinne Cusumano