Abstract: Enzymes and recombinant host cells for the biosynthesis of clinically important prenylated polyketides of the cannabinoid family are provided. Using readily available starting materials, heterologous enzymes (e.g., bacterial CoA-transferases and CoA-ligases) are used to direct cannabinoid biosynthesis in host cells such as recombinant yeast cells.

Abstract: The disclosure provides methods and probes used to dispense flowable materials from a packaged source, such as a bag in box container. The probes are adapted to engage with one or more dispensing components, for example, spouts, faucets, caps, bags, boxes, or other dispensing components. The disclosure also provides methods of using the probe, including connecting the probe to one or more dispensing components, for example flip caps, and methods of dispensing the packaged flowable material.

Abstract: Filtering assemblies to be used with a flowable material container. The assembly includes a filtering screen. The assembly further includes filtering media. The filtering media includes activated carbon. The filtering media includes dissolvable material. The assembly further includes a filtering basket to contain the filtering media. The assembly further includes a valve assembly. The assembly further includes a spout with a filter. The spout further includes a removable filter. The removable filter is configured to extend beyond the end of the spout. The removable filter includes circulation holes. The removable filter is configured to be pushed into the spout by a closure cap. The removable filter is configured to contain filtering media.

Abstract: Filtering assemblies to be used with a flowable material container. The assembly includes a filtering screen. The assembly further includes filtering media. The filtering media includes activated carbon. The filtering media includes dissolvable material. The assembly further includes a filtering basket to contain the filtering media. The assembly further includes a valve assembly. The assembly further includes a spout with a filter. The spout further includes a removable filter. The removable filter is configured to extend beyond the end of the spout. The removable filter includes circulation holes. The removable filter is configured to be pushed into the spout by a closure cap. The removable filter is configured to contain filtering media.

Abstract: A fitment assembly for use with a spout of a fluid container. The assembly includes a fitment and a poppet seal with a flexible element. The fitment includes a top portion and a bottom portion. The poppet seal extends from the bottom portion into the top portion. An attachment portion secures the flexible element within the bottom portion of the fitment. The flexible element provides a closing force to move the poppet seal from a closed to an open position. The poppet seal has a closed position, an open position, and a transport position. The poppet seal has a central support member that extends from the sealing surface of the poppet seal into the top portion of the fitment in the closed and transport condition.

Abstract: Disclosed herein is a fluid transfer assembly for dispensing flowable material from a container, the fluid transfer assembly having a spout, a screw cap body, and an aseptic plug, wherein the aseptic plug is configured to form an aseptic seal with the screw cap body.

Abstract: The present application relates to a system for evacuating fluid from a flexible container. The system includes a spout connected to a flexible container. A passageway within the spout is in fluid communication with an inside of the flexible container, and the passageway has a top end and a bottom end. An evacuation facilitating structure is positioned proximate the bottom end of the passageway and has a fluid channel therethrough. The evacuation facilitating structure blocks portions of the wall of the flexible container from entering the bottom end of the passageway and preventing fluid from evacuating the container via the passageway.

Abstract: A valve assembly for use with a spout. The assembly includes a slide that includes a side wall, an end wall, a slide flange, and an anti-tamper strap. The side wall includes a dispensing hole. The assembly further includes a sleeve and a cap that includes an inlet, an outlet, and a cap flange. The cap flange includes a strap cavity. The cap is configured to be slidably inserted into a spout, the sleeve is configured to be slidably inserted into the cap, the slide is configured to be slidably inserted into the sleeve, and the anti-tamper strap is configured to be inserted into the strap cavity.

Abstract: The present application relates to a system for evacuating fluid from a flexible container. The system includes a spout connected to a flexible container. A passageway within the spout is in fluid communication with an inside of the flexible container, and the passageway has a top end and a bottom end. An evacuation facilitating structure is positioned proximate the bottom end of the passageway and has a fluid channel therethrough. The evacuation facilitating structure blocks portions of the wall of the flexible container from entering the bottom end of the passageway and preventing fluid from evacuating the container via the passageway.

Abstract: Disclosed herein is a dispensing assembly for dispensing flowable material from a container. The dispensing assembly has a spout that communicates with the flowable material and defines a spout retention element. The assembly further has a cap configured to releasably attach to the spout. The cap has a first collar and a second collar, the first collar defining a cap retention element. The cap retention element is configured to contact the spout retention element such that the cap is affixed to the spout, and the engagement between the cap retention element and the spout retention element is reversible, such that the cap is removed from contacting the spout.

Abstract: A fitment assembly for use with a spout of a fluid container. The assembly includes a fitment and a poppet seal with a flexible element. The fitment includes a top portion and a bottom portion. The poppet seal extends from the bottom portion into the top portion. An attachment portion secures the flexible element within the bottom portion of the fitment. The flexible element provides a closing force to move the poppet seal from a closed to an open position. The poppet seal has a closed position, an open position, and a transport position. The poppet seal has a central support member that extends from the sealing surface of the poppet seal into the top portion of the fitment in the closed and transport condition.

Abstract: Filtering assemblies to be used with a flowable material container. The assembly includes a filtering screen. The assembly further includes filtering media. The filtering media includes activated carbon. The filtering media includes dissolvable material. The assembly further includes a filtering basket to contain the filtering media. The assembly further includes a valve assembly. The assembly further includes a spout with a filter. The spout further includes a removable filter. The removable filter is configured to extend beyond the end of the spout. The removable filter includes circulation holes. The removable filter is configured to be pushed into the spout by a closure cap. The removable filter is configured to contain filtering media.

Abstract: Disclosed herein is a fluid transfer assembly for dispensing flowable material from a container, the fluid transfer assembly having a spout, a screw cap body, and an aseptic plug, wherein the aseptic plug is configured to form an aseptic seal with the screw cap body.

Abstract: A valve assembly for use with a spout. The assembly includes a slide that includes a side wall, an end wall, a slide flange, and an anti-tamper strap. The side wall includes a dispensing hole. The assembly further includes a sleeve and a cap that includes an inlet, an outlet, and a cap flange. The cap flange includes a strap cavity. The cap is configured to be slidably inserted into a spout, the sleeve is configured to be slidably inserted into the cap, the slide is configured to be slidably inserted into the sleeve, and the anti-tamper strap is configured to be inserted into the strap cavity.

Abstract: Disclosed are devices and methods for dispensing flowable material. A dispensing assembly may include a spout defining an internal surface and a passage therethrough, the spout having a first receptacle defined on the interior surface; a first slider insertable into the spout, the first slider having an external surface that defines a first locking ridge configured to releasably engage with the first receptacle; and a second slider insertable into the first slider. The first slider may be configured to move within the spout and be configured to have a first configuration and a second configuration different from the first configuration.

Abstract: A probe for dispensing a flowable material includes a body having a first end and a second and a passage extending therethrough. The probe has a first engagement portion configured to have a deformed state when the first end of the body is in contact with a dispensing component, and an undeformed state. The probe has a channel having a floor and two walls and is on the first engagement portion. The probe has a second engagement portion to frictionally fit within the dispensing component and to form a seal between the probe and the component. The probe has a locking groove to prevent movement of the probe relative to the dispensing component. In the undeformed state, the walls of the channel are spaced apart at a first distance, and in the deformed state, the walls are spaced apart at a second, smaller distance.

Abstract: Disclosed herein is a fluid transfer assembly for dispensing flowable material from a container, the fluid transfer assembly having a spout, a screw cap body, and an aseptic plug, wherein the aseptic plug is configured to form an aseptic seal with the screw cap body.

Abstract: The present invention relates to a universal fitment, method of assembling the universal fitment, and method of dispensing liquids using such universal fitment. The universal fitment of the present invention has features to engage a quick-connect-disconnect dispensing connector or a screw-on connector dispensing connector for the dispensing of liquids and semi-liquids from a collapsible bag.

Abstract: The disclosure provides methods and probes used to dispense flowable materials from a packaged source, such as a bag in box container. The probes are adapted to engage with one or more dispensing components, for example, spouts, faucets, caps, bags, boxes, or other dispensing components. The disclosure also provides methods of using the probe, including connecting the probe to one or more dispensing components, for example flip caps, and methods of dispensing the packaged flowable material.

Abstract: The present invention relates to a universal fitment, method of assembling the universal fitment, and method of dispensing liquids using such universal fitment. The universal fitment of the present invention has features to engage a quick-connect-disconnect dispensing connector or a screw-on connector dispensing connector for the dispensing of liquids and semi-liquids from a collapsible bag.