Patents by Inventor James W. Malecha

James W. Malecha has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DESAZADESFERROTHIOCIN ANALOGUES AS METAL CHELATION AGENTS
    Publication number: 20150259306
    Abstract: Disclosed herein are new compounds of desazadesferrothiocin polyether (DADFT-PE) analogues, as well as pharmaceutical compositions comprising them and their application as metal chelation agents for the treatment of disease. Methods of chelation of iron and other metals in a human or animal subject are also provided for the treatment of metal overload and toxicity.
    Type: Application
    Filed: May 27, 2015
    Publication date: September 17, 2015
    Inventor: James W. Malecha, JR.
  • DESAZADESFERROTHIOCIN AND DESAZADESFERROTHIOCIN POLYETHER ANALOGUES AS METAL CHELATION AGENTS
    Publication number: 20130053387
    Abstract: Disclosed herein are new compounds of desazadesferrothiocin polyether (DADFT-PE) analogues, as well as pharmaceutical compositions comprising them and their application as metal chelation agents for the treatment of disease. Methods of chelation of iron and other metals in a human or animal subject are also provided for the treatment of metal overload and toxicity.
    Type: Application
    Filed: May 4, 2011
    Publication date: February 28, 2013
    Applicant: FerroKin BioScience, Inc.
    Inventor: James W. Malecha
  • Carbazole inhibitors of histamine receptors for the treatment of disease
    Patent number: 8080566
    Abstract: The present invention relates to carbazole compounds, pharmaceutical compositions comprising them, and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
    Type: Grant
    Filed: June 11, 2009
    Date of Patent: December 20, 2011
    Assignee: Kalypsys, Inc
    Inventors: Mehmet Kahraman, Allen J. Borchardt, Robert L. Davis, Stewart A. Noble, James W. Malecha
  • Sulfonyl-substituted bicyclic compounds as modulators of PPAR
    Patent number: 7915253
    Abstract: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
    Type: Grant
    Filed: September 4, 2008
    Date of Patent: March 29, 2011
    Assignee: Kalypsys, Inc
    Inventors: Stewart A. Noble, Guy Oshiro, James W. Malecha, Cunxiang Zhao, Carmen K. Robinson, Sergio G. Duron, Michael Sertic, Andrew K. Lindstrom, Andrew K. Shiau, Christopher D. Bayne, Mehmet Kahraman, Boliang Lou, Steve P. Govek
  • Sulfonyl-substituted bicyclic compounds as modulators of PPAR
    Patent number: 7834004
    Abstract: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
    Type: Grant
    Filed: September 4, 2008
    Date of Patent: November 16, 2010
    Assignee: Kalypsys, Inc
    Inventors: Stewart A. Noble, Guy Oshiro, James W. Malecha, Cunxiang Zhao, Carmen Robinson, Sergio G. Duron, Michael Sertic, Andrew K. Lindstrom, Andrew K. Shiau, Christopher D Bayne, Mehmet Kahraman, Boliang Lou, Steven P. Govek
  • ARYL-SUBSTITUTED HETEROCYCLIC PDE4 INHIBITORS AS ANTI-INFLAMMATORY AGENTS
    Publication number: 20100105729
    Abstract: Disclosed herein are potent and selective aryl-substituted heterocyclic compounds, useful as inhibitors of phosphodiesterase 4 (PDE4), compositions comprising the same, and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of PDE4 activity are also provided, as well as methods for the treatment of inflammatory diseases and other diseases in which PDE4 or one of its isoforms may play a role.
    Type: Application
    Filed: September 20, 2007
    Publication date: April 29, 2010
    Applicant: KALYPSYS, INC.
    Inventors: Steven P. Govek, Guy Oshiro, Stewart A. Noble, James W. Malecha, Andrew K. Shiau
  • HETEROCYCLIC INHIBITORS OF PDE4
    Publication number: 20090275586
    Abstract: The present invention is directed to potent and selective heterocyclic compounds, useful as inhibitors of phosphodiesterase 4 (PDE4), compositions comprising the same, and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of PDE4 activity are also provided, as well as methods for the treatment of inflammatory diseases and other diseases in which PDE4 or one of its isoforms may play a role.
    Type: Application
    Filed: September 20, 2007
    Publication date: November 5, 2009
    Applicant: KALYPSYS, INC.
    Inventors: Steven P. Govek, Guy Oshiro, Stewart A. Noble, James W. Malecha, Andrew K. Shiau
  • SULFONYL-SUBSTITUTED BICYCLIC COMPOUNDS AS MODULATORS OF PPAR
    Publication number: 20090264417
    Abstract: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
    Type: Application
    Filed: September 4, 2008
    Publication date: October 22, 2009
    Applicant: KALYPSYS, INC.
    Inventors: Stewart A. Noble, Guy Oshiro, James W. Malecha, Cunxiang Zhao, Carmen Robinson, Sergio G. Duron, Michael Sertic, Andrew K. Lindstrom, Andrew K. Shiau, Christopher D. Bayne, Mehmet Kahraman, Boliang Lou, Steven P. Govek
  • SULFONYL-SUBSTITUTED BICYCLIC COMPOUNDS AS MODULATORS OF PPAR
    Publication number: 20090227599
    Abstract: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
    Type: Application
    Filed: March 3, 2009
    Publication date: September 10, 2009
    Applicant: KALYPSYS, INC.
    Inventors: Stewart A. Noble, Guy Oshiro, James W. Malecha, Cunxiang Zhao, Sergio G. Duron, Andrew K. Lindstrom, Andrew K. Shiau, Boliang Lou, Steven P. Govek, David J. Thomas
  • Sulfonyl-Substituted Aryl Compounds as Modulators of Peroxisome Proliferator Activated Receptors
    Publication number: 20090143396
    Abstract: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
    Type: Application
    Filed: October 11, 2006
    Publication date: June 4, 2009
    Inventors: James W. Malecha, Andrew K. Lindstrom, Sergio G. Duron, David J. Thomas
  • Sulfonyl-substituted bicyclic compounds as modulators of PPAR
    Patent number: 7517884
    Abstract: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
    Type: Grant
    Filed: May 16, 2006
    Date of Patent: April 14, 2009
    Assignee: Kalypsys Inc.
    Inventors: James W. Malecha, Sergio G. Duron, Andrew K. Lindstrom
  • Sulfonyl-substituted bicyclic compounds as modulators of PPAR
    Patent number: 7494999
    Abstract: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
    Type: Grant
    Filed: October 25, 2005
    Date of Patent: February 24, 2009
    Assignee: Kalypsys, Inc
    Inventors: Stewart A. Noble, Guy Oshiro, James W. Malecha, Cunxiang Zhao, Carmen Robinson, Sergio G. Duron, Michael Sertic, Andrew K. Lindstrom, Andrew K. Shiau, Christopher D. Bayne, Mehmet Kahraman, Boliang Lou, Steven P. Govek
  • SULFONYL-SUBSTITUTED BICYCLIC COMPOUNDS AS MODULATORS OF PPAR
    Publication number: 20090029971
    Abstract: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
    Type: Application
    Filed: September 4, 2008
    Publication date: January 29, 2009
    Applicant: KALYPSYS, INC.
    Inventors: Stewart A. Noble, Guy Oshiro, James W. Malecha, Cunxiang Zhao, Carmen Robinson, Sergio G. Duron, Michael Sertic, Andrew K. Lindstrom, Andrew K. Shiau, Christopher D. Bayne, Mehmet Kahraman, Boliang Lou, Steve P. Govek
  • Novel Compounds as Modulators of Ppar
    Publication number: 20080287477
    Abstract: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
    Type: Application
    Filed: October 11, 2006
    Publication date: November 20, 2008
    Applicant: KALYPSYS, INC.
    Inventors: James W. Malecha, Andrew K. Lindstrom, Sergio G. Duron, Steven P. Govek
  • Process for preparing prodrugs of benzenesulfonamide-containing COX-2 inhibitors
    Patent number: 7420061
    Abstract: Prodrugs of COX-2 inhibitors are described as being useful in treating inflammation and inflammation-related disorders.
    Type: Grant
    Filed: September 13, 2004
    Date of Patent: September 2, 2008
    Assignee: Pharmacia Corporation
    Inventors: John J. Talley, James W. Malecha, Stephen Bertenshaw, Matthew J. Graneto, Jeffery S. Carter, Jinglin Li, Srinivasan R. Nagarajan, David L. Brown, Donald J. Rogier, Jr., Thomas D. Penning, Ish K. Khanna, Xiangdong Xu, Richard M. Weier
  • SULFONYL-SUBSTITUTED BICYCLIC COMPOUNDS AS MODULATORS OF PPAR
    Publication number: 20070270434
    Abstract: The present invention relates to compounds and methods useful as inhibitors of PPAR, particularly PPAR?, and for the treatment or prevention of PPAR-mediated diseases, including metabolic diseases.
    Type: Application
    Filed: May 16, 2007
    Publication date: November 22, 2007
    Applicant: KALYPSYS, INC.
    Inventors: James W. Malecha, Stewart A. Noble, Sergio G. Duron, Andrew Lindstrom, Andrew Shiau, Steven Govek
  • Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease
    Patent number: 7271195
    Abstract: Disclosed herein are carbonyl compounds of Formula I, II, or III, and others as described herein. Also disclosed are methods of treating disease, such as cancer, neurological disorders, including polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, autoimmune diseases and cardiovascular conditions, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
    Type: Grant
    Filed: June 10, 2004
    Date of Patent: September 18, 2007
    Assignee: Kalypsys, Inc.
    Inventors: Paul L. Wash, Brandon M. Wiley, Christian Hassig, James W. Malecha, Stewart A. Noble
  • Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation
    Patent number: 6951949
    Abstract: A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders.
    Type: Grant
    Filed: November 3, 2003
    Date of Patent: October 4, 2005
    Assignee: Pharmacia Corporation
    Inventors: John J Talley, Thomas D Penning, Paul W Collins, Donald J Rogier, Jr., James W Malecha, Julie M Miyashiro, Stephen R Bertenshaw, Ish K Khanna, Matthew J Graneto, Roland S Rogers, Jeffery S Carter, Stephen H. Docter, Stella S Yu
  • Anilino liver X-receptor modulators
    Patent number: 6900244
    Abstract: The present invention is directed to selective LXR modulators, small molecule compounds corresponding to Formula I and is further directed to a process of treating a condition in a mammal that is modulated by LXR using a therapeutically effective dose of a compound of Formula I.
    Type: Grant
    Filed: May 23, 2003
    Date of Patent: May 31, 2005
    Assignee: Pharmacia Corporation
    Inventors: Jennifer Ann Van Camp, James W. Malecha, Julie M. Miyashiro, Gary A. DeCrescenzo, Joe T. Collins, Monica J. Kalman
  • Dihydrostilbene alkanoic acid derivatives
    Patent number: 6833366
    Abstract: The present invention relates to a class of compounds represented by the Formula 1. or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula 1, and methods of selectively inhibiting or antagonizing the &agr;v&bgr;3 and/or the &agr;v&bgr;5 integrin.
    Type: Grant
    Filed: September 9, 2003
    Date of Patent: December 21, 2004
    Assignee: Pharmacia Corporation
    Inventors: Thomas Rogers, Michael Clare, Hwang-Fun Lu, Mark Russell, James W. Malecha, Ish Kumar Khanna, Thomas Penning, Srinivasan Raj Nagarajan