Abstract: The present disclosure includes antibodies that specifically bind integrin alpha 11 beta 1 (?11?1), as well as methods of making and using such antibodies.

Abstract: A device for percutaneously accessing the pericardial space has a tubular body wall enclosing a lumen. The wall ends in a tip that has an inferior aperture in fluid communication with the lumen. The tip surrounds and roofs over the aperture to form an chamber above the aperture, The portion of the tip over the aperture has a plurality of grooves in fluid communication with the lumen. The device includes a hollow body with a piercing end moveable in the first tubular body to extend into the chamber. A vacuum applied by the device to the chamber draws a bleb of pericardium into the chamber where it can be safely pierced by the piercing body to fain access to the pericardial space.

Abstract: A glycosyl transferase from Chinese hamster and related methods are described.

Abstract: A glycosyl transferase from Chinese hamster and related methods are described.

Abstract: A glycosyl transferase from Chinese hamster and related methods are described.

Abstract: A urine collection and disposal system and method applies subatmospheric pressure to a receptacle open to atmospheric pressure which has a urine outlet in fluid communication with a source of subatmospheric pressure. The receptacle receives urine in the receptacle from a urine donor and removes the urine from the receptacle, transporting the removed urine to a reservoir under the force of a pressure differential between atmospheric pressure at the receptacle and subatmospheric pressure at the reservoir. The reservoir urine is discharged at atmospheric pressure, for disposal, from the reservoir while maintaining the reservoir at subatmospheric pressure. A plurality of the receptacles allows simultaneously providing urine to the reservoir from more than one of the receptacles. Sanitizing fluid may be supplied intermediate the receptacle and the reservoir for transport to the reservoir under the force of the pressure differential between atmospheric and subatmospheric.

Abstract: A urine collection and disposal system and method applies subatmospheric pressure to a receptacle open to atmospheric pressure which has a urine outlet in fluid communication with a source of subatmospheric pressure. The receptacle receives urine in the receptacle from a urine donor and removes the urine from the receptacle, transporting the removed urine to a reservoir under the force of a pressure differential between atmospheric pressure at the receptacle and subatmospheric pressure at the reservoir. The reservoir urine is discharged at atmospheric pressure, for disposal, from the reservoir while maintaining the reservoir at subatmospheric pressure. A plurality of the receptacles allows simultaneously providing urine to the reservoir from more than one of the receptacles. Sanitizing fluid may be supplied intermediate the receptacle and the reservoir for transport to the reservoir under the force of the pressure differential between atmospheric and subatmospheric.

Abstract: A urine collection and disposal system and method applies subatmospheric pressure to a receptacle open to atmospheric pressure which has a urine outlet in fluid communication with a source of subatmospheric pressure. The receptacle receives urine in the receptacle from a urine donor and removes the urine from the receptacle, transporting the removed urine to a reservoir under the force of a pressure differential between atmospheric pressure at the receptacle and subatmospheric pressure at the reservoir. The reservoir urine is discharged at atmospheric pressure, for disposal, from the reservoir while maintaining the reservoir at subatmospheric pressure. A plurality of the receptacles allows simultaneously providing urine to the reservoir from more than one of the receptacles. Sanitizing fluid may be supplied intermediate the receptacle and the reservoir for transport to the reservoir under the force of the pressure differential between atmospheric and subatmospheric.

Abstract: Apparatus for accessing the pericardial space including an elongate tubular member terminating in an opening that permits the induction of pericardial tissue. A piercing member operating within the tubular member can pierce the pericardial tissue providing guidewire access to the pericardial space of a patient's heart.

Abstract: A pericardiocentesis apparatus and method for accessing the pericardial space. The invention consists of inserting a percutaneous tube whose tip has a hole which is positioned over and contacts the anterior pericardium. Introducing a vacuum within said tube forms a pericardial bleb within that hole. A guided needle within the tube is advanced to puncture the pericardial bleb while avoiding contact with the epicardium. A hollow filament or electrocardial lead or flexible guide wire within said needle can then be advanced into said pericardial cavity. The guide wire may be used to guide a intrapericardial catheter into the pericardial space for injection or infusion of selected therapeutic agents into the pericardial space to treat various heart and blood vessel diseases. Controlled drug release material(s) can be injected through said needle for the slow and/or sustained delivery of said therapeutic agents into said pericardial cavity.

Abstract: A method of conducting and electronically documenting analyte screening testing such as testing for drugs of abuse uses one or more analyte screening media carried in a support, the media expressing results of reaction visibly on the media. The method includes contacting the analyte screening support with a bodily fluid of the donor to allow reaction of the reactant with an analyte tested by the reactant if present in the bodily fluid, then electronically imaging the reacted analyte screening support visibly showing the test results, and incorporating that electronic image into a read-only electronic form. The donor provides an authentication into the electronic form or onto a print copy of the form.

Abstract: A pericardiocentesis apparatus and method for accessing the pericardial space. The invention consists of inserting a percutaneous tube whose tip has a hole which is positioned over and contacts the anterior pericardium. Introducing a vacuum within said tube forms a pericardial bleb within that hole. A guided needle within the tube is advanced to puncture the pericardial bleb while avoiding contact with the epicardium. A hollow filament or electrocardial lead or flexible guide wire within said needle can then be advanced into said pericardial cavity. The guide wire may be used to guide a intrapericardial catheter into the pericardial space for injection or infusion of selected therapeutic agents into the pericardial space to treat various heart and blood vessel diseases. Controlled drug release material(s) can be injected through said needle for the slow and/or sustained delivery of said therapeutic agents into said pericardial cavity.

Abstract: A centrifugal blood pump driver comprises a motor housing and the housing contains a motor for rotationally driving the centrifugal blood pump and a controller operatively associated with the motor for controlling the rotational speed of the motor; a speed selector for generating a selected speed signal signifying a selected rotational speed for the motor; sensors operatively associated with the motor or controller for sensing the rotational speed of the motor and outputting a monitor signal signifying such rotational speed; program memory for storage of a program of microprocessor readable instructions; a microprocessor under program control, in electrical connection with the controller, the speed selector, the sensor and the program memory, for receiving the selected speed signal and generating a speed control signal to the controller signifying the selected speed for the controller, and for receiving the monitor signal and outputting a display signal; a display in electrical communication with the micropro

Abstract: Patient blood in an extracorporeal flow circuit (such as a cardiopulmonary bypass machine) is contacted with one or more nitric oxide feeds at least one of which is upstream of the circuit pump, to provide a concentration of nitric oxide in the blood effective to inhibit activation of blood platelets and reduce whole body inflammation of the patient as a result of a procedure using the extracorporeal circulation.

Abstract: This invention relates to the method of use of a congener of an endothelium-derived bioactive composition of matter, which comprises administering said congener percutaneously to a site proximately adjacent the exterior of a coronary blood vessel at a therapeutically effective dosage.

Abstract: A centrifugal blood pump driver comprises a motor housing and the housing contains a motor for rotationally driving the centrifugal blood pump and a controller operatively associated with the motor for controlling the rotational speed of the motor; a speed selector for generating a selected speed signal signifying a selected rotational speed for the motor; sensors operatively associated with the motor or controller for sensing the rotational speed of the motor and outputting a monitor signal signifying such rotational speed; program memory for storage of a program of microprocessor readable instructions; a microprocessor under program control, in electrical connection with the controller, the speed selector, the sensor and the program memory, for receiving the selected speed signal and generating a speed control signal to the controller signifying the selected speed for the controller, and for receiving the monitor signal and outputting a display signal; a display in electrical communication with the micropro

Abstract: A container for pharmaceutical items, comprising a tray having at least one compartment adapted to retrievably contain at least one pharmaceutical item, each said compartment having associated therewith a lid movable between a closed position restricting access to the associated compartment and an open position permitting access to the associated compartment, and each lid having associated therewith a mechanism responsive to control signals from a computer to permit movement between the closed and open positions.

Abstract: A pericardiocentesis apparatus and method for accessing the pericardial space. The invention consists of inserting a percutaneous tube whose tip has a hole which is positioned over and contacts the anterior pericardium. Introducing a vacuum within the tube forms a pericardial bleb within that hole. A guided needle within the tube is advanced to puncture the pericardial bleb while avoiding contact with the epicardium. A hollow filament or electrocardial lead or flexible guide wire within the needle can then be advanced into said pericardial cavity. The guide wire may be used to guide a intrapericardial catheter into the pericardial space for injection or infusion of selected therapeutic agents into the pericardial space to treat various heart and blood vessel diseases. Controlled drug release material(s) can be injected through the needle for the slow and/or sustained delivery of the therapeutic agents into the pericardial cavity.

Abstract: A fluid sample receptacle provides a means of assuring uncontaminated, multiple samples of a fluid specimen. An upper or isolated sample chamber and a lower or primary sample chamber provide redundant test samples. A cover or lid with a downwardly extending column includes a stopper with a removable plug attached to automatically seal the lower sample chamber when the cover is sealed across the top of the upper chamber. This feature guarantees that the sample chambers are sealed or isolated simultaneously and that the test samples are therefore identical when taken. Tamper evident seals prove that either sample has not been contaminated. A preferred embodiment provides a bellows assembly to accommodate variations in ambient pressure and to provide a positive means of expelling a precise quantity of fluid from the receptacle for testing.

Abstract: Patient blood in an extracorporeal flow circuit (such as a cardiopulmonary bypass machine) is contacted with one or more nitric oxide feeds at least one of which is upstream of the circuit pump, to provide a concentration of nitric oxide in the blood effective to inhibit activation of blood platelets and reduce whole body inflammation of the patient as a result of a procedure using the extracorporeal circulation.