Patents by Inventor James W. Simpkins

James W. Simpkins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for treating male sexual dysfunction
    Patent number: 4863911
    Abstract: The invention provides a method for treating sexual dysfunction in male mammals using a compound of the formula[E--DHC] (I)or a non-toxic pharmaceutically acceptable salt thereof, wherein [E] is an estrogen and [DHC] is the reduced, biooxidizable, blood-brain barrier-penetrating, lipoidal form of a dihydropridine.revreaction.pyridinium salt redox carrier. Compositions for use in the subject method are also disclosed. A preferred compound for use in the method and compositions is an estradiol derivative, namely, 17.beta.-[(1-methyl-1,4-dihydro-3-pyridinyl)carbonyloxy]estra-1,3,5(10)-tr ien-3-ol.
    Type: Grant
    Filed: August 4, 1986
    Date of Patent: September 5, 1989
    Assignee: University of Florida
    Inventors: Wesley R. Anderson, Jr., Nicholas S. Bodor, James W. Simpkins
  • Method for eliciting anxiolysis
    Patent number: 4786647
    Abstract: The invention provides a method for relieving anxiety in a mammal using a compound of the formula ##STR1## wherein R is Benzyl or cyclohexyl, or a non-toxic pharmaceutically acceptable salt thereof. A preferred compound for use in the subject method is 1-methyl-3-{N-[(3'-benzyloxycarbonyl)propyl]}carbamoyl-1,4-dihydropyridine .
    Type: Grant
    Filed: June 30, 1986
    Date of Patent: November 22, 1988
    Assignees: University of Florida, Pharmatec, Inc.
    Inventors: James W. Simpkins, Warren C. Stern
  • Method and compositions for weight control
    Patent number: 4617298
    Abstract: The invention provides a method for controlling mammalian body weight using a compound of the formula[E--DHC] (I)or a non-toxic pharmaceutically acceptable salt thereof, wherein [E] is an estrogen and [DHC] is the reduced, biooxidizable, blood-brain barrier penetrating, lipoidal form of a dihydropyridine.revreaction.pyridinium salt redox carrier. Novel compositions for weight control comprising a compound of formula (I) or its salt are also disclosed. A preferred compound for use in the subject method and compositions is an estradiol derivative, namely, 17 .beta.-[(1-methyl-1,4-dihydro-3-pyridinyl)carbonyloxy]estra-1,3,5(10)-trie n-3-ol.
    Type: Grant
    Filed: October 22, 1985
    Date of Patent: October 14, 1986
    Assignee: University of Florida
    Inventors: Nicholas S. Bodor, Kerry S. Estes, James W. Simpkins