Abstract: Various compositions, methods, and devices are provided that use fluorescent nanoparticles to function as markers, indicators, and light sources. In one embodiment, an endoscopic adaptor is provided for viewing fluorescent nanoparticles. The adaptor can be configured to removably mate to a portion of an endoscope, such as an eyepiece, and it can be adapted to contain a filter for filtering light received through the viewing lumen of the eyepiece. In an exemplary embodiment, the filter is configured to transmit fluorescent light while blocking visible light, to thereby enable a structure containing one or more fluorescent nanoparticles to be viewed through the endoscope.

Abstract: Methods and devices are provided for activating brown adipose tissue (BAT). Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss. In one embodiment, a medical device is provided that activates BAT by electrically stimulating nerves that activate the BAT and/or electrically stimulating brown adipocytes directly, thereby increasing thermogenesis in the BAT and inducing weight loss through energy expenditure.

Abstract: A surgical staple including features which can reduce bleeding from soft tissue. In various embodiments, the surgical staple can include at least one deformable member which can puncture a hole in soft tissue as it is inserted therethrough. The deformable member can include a material thereon, or can be comprised of a material, which can expand and substantially fill the puncture hole in the soft tissue. In various embodiments, at least a portion of the deformable member can be coated with a hydrophilic material which can expand when exposed to water, or other bodily fluids, and apply a compression force to the perimeter of the puncture hole. Such a compression force can reduce bleeding from the puncture hole and thereby reduce any potential complications resulting therefrom.

Abstract: Various exemplary methods and devices are provided for manipulating and/or anchoring devices and body parts during surgical procedures. In one embodiment, an anchor member is provided for anchoring a device or body part to tissue, such as an internal wall of a body cavity. The device can be, for example, an endoscopic device, an accessory channel coupled to an endoscopic device, or a support member adapted to support or manipulate an organ. The anchor member can include or form an opening through which the device can be inserted. The anchor member or device can thus be manipulated relative to the tissue to control movement of and/or provide support to the device, tools inserted through the device, and/or organs grasped by the device or tools.

Abstract: A multiple use fluid dispenser dispenses a flowable material in a precise pattern and quantity with leaking and clogging between dispensing avoided by employing a trigger fired syringe plunger to expel a fixed volume through a band. Between strokes, an advancement knob rotates the band over a distal dispensing tip to a nondispensing location that wipes excess flowable material and seals a dispensing orifice in a fluid conduit. The advancement knob further may rotate the band to a dispensing position wherein a combination of one or more dispensing holes produce a desired pattern and rate of flow with material over the dispensing hole(s) serving to initiate the flowable material, to control placement, serve as a detachable bandage or buttress material, etc.

Abstract: A surgical method, system, kit, and various devices are provided for use in, among other things, vaginal entry during a natural orifice translumenal endoscopic surgical procedure. A system and/or method provide for the rapid creation of a conduit and/or multiple ports in a natural orifice, such as a patient's vagina, while accommodating anatomical variation to reduce the need to excise additional tissue from the patient.

Abstract: A staple having a crown, a deformable leg extending from the crown, and a spring extending from the crown configured to compress tissue between the spring and the deformable member. Owing to the flexibility of the spring, the staple can accommodate a wide range of tissue thicknesses while still compressing the tissue captured therein. As a result, a single staple design can be used in a wide variety of surgical procedures thereby reducing the amount of staple designs that must be provided to the surgeon. In at least one embodiment, the staple includes a crushable member. This crushable member can include a plastically deformable first portion and an elastically deformable second portion. The present invention can also include, in various embodiments, a crown, a first deformable member extending from the crown, and means for compressing the tissue against the first deformable member.

Abstract: A number of surgical devices for the mixing and dispensement of a dual component surgical adhesive onto tissue are described. The surgical devices can provide adhesive storage chambers for the adhesive components within the surgical device and can have removable cartridges that draw and mix and apply the adhesive onto tissue. The removable cartridges can be easily replaced when clogged with set adhesive. Alternately, an adhesive dispensing device can comprise an adhesive dispensing gun containing the dual components of the adhesive and a plurality of rotatable orifices that can dispense the adhesive. One orifice can be selected and aligned with the adhesive dispensing gun to mix and apply the adhesive onto tissue. A fresh orifice can be rotated into alignment with the gun should a prior orifice become blocked.

Abstract: A tissue suspension device has an elongated spanning element with a first and a second end. A suspending element is attachable to the spanning element. A first supporting element is attached to the first end of the spanning element, and a second supporting element is attached to the second end of the spanning element. The tissue suspension device substantially spans the transverse width of the body cavity and suspends tissue within the body cavity. The first and second supporting elements are attachable to the body wall, which supports the weight of the suspended tissue.

Abstract: A retractor instrument for use in surgery having a body section and attachment tabs for securing the retractor to tissue. The retractor may have multiple body sections joined by hinges or ribs and may be rigid or flexible or some combination thereof. The retractor may comprise bioabsorbable material as well as hemostatic material. The retractor is suitable for use with clips, staples, sutures and tacks.

Abstract: A method and system for treating tissue with a surgical device includes the steps of displaying an image created by collecting imaging data from an imaging device, selecting at least one tissue target from the image, collecting image data and tracking the tissue target during at least one respiration cycle, determining the dwell position of the tissue target, and displaying an image created from image data collected with the tissue target at the dwell position. The method may further include determining the position and orientation of the surgical device with respect to the dwell position and indicating the trajectory of the surgical device on the display screen. The method may further include the steps of monitoring the respiration cycle, indicating when the tissue target is approaching the dwell position, positioning the surgical device in the patient based upon the dwell position and trajectory and treating the tissue target.

Abstract: Disclosed is an instrument for use in a procedure to effect anastomosis of a patient's bladder and urethra following a prostatectomy having a tube assembly, and an end effector assembly operably supported by the tube assembly, where the end effector assembly includes an anchor for insertion into and through the patient's bladder wall and pelvic floor and an anchor guide associated therewith.

Abstract: Methods and devices are provided for cutting and fastening tissue. In one embodiment, a surgical device can be used to at least partially transect a stomach by not cutting and/or not fastening a portion of tissue engaged in an end effector located at the device's distal end. A portion of the stomach can be engaged by the end effector, and the end effector can be actuated to cut and/or to apply one or more fasteners to tissue engaged in a distal portion of the end effector but not to cut and/or apply fasteners to tissue engaged in a proximal portion of the end effector. In a similar way, the surgical device can be used in any surgical procedure in which it is desired to cut and/or fasten a distal portion of tissue engaged by the end effector but not a proximal portion of tissue engaged by the end effector.

Abstract: A staple having a crown, a deformable leg extending from the crown, and a spring extending from the crown configured to compress tissue between the spring and the deformable member. Owing to the flexibility of the spring, the staple can accommodate a wide range of tissue thicknesses while still compressing the tissue captured therein. As a result, a single staple design can be used in a wide variety of surgical procedures thereby reducing the amount of staple designs that must be provided to the surgeon. In at least one embodiment, the staple includes a crushable member. This crushable member can include a plastically deformable first portion and an elastically deformable second portion. The present invention can also include, in various embodiments, a crown, a first deformable member extending from the crown, and means for compressing the tissue against the first deformable member.

Abstract: A visceral barrier has a barrier element that is changeable between an opened and a closed configuration. The barrier element may be positioned while in the opened configuration to temporarily reposition the viscera within the body cavity. A method of repositioning the viscera in a body cavity of a patient during a surgical procedure includes providing a visceral barrier, introducing the visceral barrier into the body cavity when the barrier element is in the closed configuration, opening the barrier element to the opened configuration, and positioning the barrier element within the body cavity to reposition the viscera and provide a space for performing a surgical procedure.

Abstract: Disclosed is an instrument, assembly, and method for use in a procedure to effect anastomosis of a patient's bladder and urethra following a prostatectomy. The instrument comprises a tube assembly having an end effector assembly operably supported thereby, where the end effector assembly includes a harness adapted to receive a balloon portion of a balloon catheter assembly.

Abstract: Provided is a two-piece anastomosis fastener that can be used to join two tissue sections together in accordance with Natural Orifice Transendoscopic Surgery (NOTES). The fastener may be releasably attached to a fastener applying instrument for delivery in accordance with such procedures. The fastener includes a first member and a second member, where the clamp members are operably configured to fasten together to clamp and hold tissue, such as gastric tissue, in juxtaposition to establish an anastomosis. The first clamp member and the second clamp member are coupled with an adhesive.

Abstract: A method for obtaining one or more tissue samples, such as from the prostate, is provided. The method can include use of a handheld, vacuum assisted, single insertion multiple sample biopsy device to remove two spaced apart volumes of prostate tissue, one on either side of the urethra. A sleeve with multiple electrodes can be received on the biopsy device or otherwise associated with the biopsy device, to provide RF energy to the biopsy site and to cauterize tissue surfaces from which the tissue samples have been taken.

Abstract: A biopsy method is disclosed. The biopsy method can be used to provide a fine needle aspiration sample and a core biopsy sample. The biopsy method can include adjusting a sample port length without removing the biopsy device from the patient.

Abstract: A fastening device for clamping and fastening tissue together with fasteners formed from an adhesive is disclosed. An embodiment of the adhesive fastening device can clamp a first and a second portion of tissue together between a first and a second jaw, and can place a fluid polymer adhesive into tissue and form it into a polymerized surgical fastener within the tissue. The adhesive fastener can be formed as a polymerized shank or shaft extending through the tissue, and can have one or more heads formed on the shank. The shank can be formed solely from the polymerizable adhesive, or can be formed from another material such as nitinol, titanium, stainless steel, suture, or a plastic. Shanks of other material can be combined with the adhesive. Alternately, an adhesive fastener can be formed extending distally from a distal end of the surgical device. And, an adhesive fastener can be formed around a luminal tissue or within luminal tissue.