Abstract: The present invention relates to a polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the bicyclic peptides of the invention are conjugated to a carrier peptide in order to greatly enhance the bacterial cell killing activity. More particularly, the invention describes peptides which are high affinity binders of penicillin-binding proteins (PBPs), such as PBP3 and PBP3a. The invention also includes pharmaceutical compositions comprising said conjugates and to the use of said conjugates in suppressing or treating a disease or disorder mediated by bacterial infection or for providing prophylaxis to a subject at risk of infection.

Abstract: A method is provided for scheduling a meeting. The method includes receiving a request from an organizer to schedule a meeting, executing a constraint satisfaction algorithm to determine at least one meeting data set comprising a value for at least one variable in a set of variables. The meeting data set defines at least one of a proposed time, room or participants for the meeting. Executing the constraint satisfaction algorithm involves performing a backtracking search within a solution domain to determine the meeting data set for the set of variables that satisfies a set of meeting constraints. If no meeting data set is determined, the set of variables and the solution domain can be revised. A next backtracking search can be performed to determine the meeting data set for the revised set of variables in the revised solution domain that satisfies one or more of the meeting constraints.

Abstract: Sustained release composition for orally administered active substances that comprises maltodextrin and cellulose. This composition is suitable for forming tablets, gels when exposed to the fluids in the gastric environment, and provides an effective sustained release medium for glucosamine-based compounds. This composition is effectively used as a stomach guard.