Patents by Inventor James Wamsley

James Wamsley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20110118239
    Abstract: A novel scalable synthesis for the preparation of 7-(3-pyridinyI)-1,7-diazaspiro[4.4)nonane has been developed, and 7-(3-pyridinyl)-1,7-diazaspiro[4.4]nonane salts have been formed with succinic acid and oxalic acid. Additionally, 7-(3-pyridinyl)-1,7-diaza-spiro[4.4]nonane has been separated into its stereoisomers via resolution with L and D di-p-toluoyltartaric acids, giving (R)- and (S)-7-(3-pyridinyl)-1,7-diazaspiro[4.4]nonane of high enantiomeric purity. Numerous solid salts of the resulting (R)- and (S)-7-(3-pyridinyl)-1,7-diazaspiro[4.4}nonane have been prepared. Methods for the preparation of the racemic and enantiomeric salts, pharmaceutical compositions comprising such salts, and uses thereof are disclosed. The salts can be administered to patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, to treat and/or prevent such disorders.
    Type: Application
    Filed: January 15, 2009
    Publication date: May 19, 2011
    Applicant: Targacept, Inc.
    Inventors: Jessica Beaver, Scott Breining, Gary Maurice Dull, Gregory J. Gatto, John Genus, Jacob Mathew, Julio A. Munoz, Inigo Pfeiffer, Steve M. Ttoler, James Wamsley, Jianxun Xie
  • Publication number: 20080085888
    Abstract: The present invention provides a combination of (a) an antipsychotic and (b) an alpha4/beta2 (?4?2)-neuronal nicotinic receptor agonist. The invention further relates to pharmaceutical compositions comprising said combination and to the use of the combination in therapy. The invention further relates to a kit comprising the combination and use of said kit in therapy.
    Type: Application
    Filed: September 14, 2007
    Publication date: April 10, 2008
    Inventors: Scott Breining, John Evenden, Edwin Johnson, Kristen Jordan, Sharon Letchworth, Craig Miller, Ladislav Mrzljak, James Wamsley, Dan Widzowski, Yun-De Xiao