Abstract: The present disclosure relates to compounds of Formula (I), which inhibit Gal-3, and include pharmaceutically acceptable salts, compositions comprising such compounds, and methods using and making such compounds and compositions.

Abstract: Disclosed herein are heterocyclic compounds that inhibit the activity of FLT3. Also described are specific irreversible inhibitors of FLT3. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the FLT3 inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of proliferative diseases or conditions, including hematological malignancies and other diseases or conditions dependent on FLT3 activity.

Abstract: Prostate-specific membrane antigen (PSMA) targeted compounds having formula (I), nanoclusters formed thereof, pharmaceutical compositions comprising a plurality of these compounds, and methods for treating and detecting cancers in a subject are described herein.

Abstract: An object induction system is disclosed for assigning handling parameters to an object. The system includes an analysis system, an association system, and an assignment system. The analysis system includes at least one characteristic perception system for providing perception data regarding an object to be processed. The association system includes an object information database and assigns association data to the object responsive to commonality with of any of the characteristic perception data with any of the characteristic recorded data. The assignment system is for assigning programmable motion device handling parameters to the indicia perception data based on the association data, and includes a workflow management system as well as a separate operational controller.

Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds, and methods of using such compounds for treatment of joint damage or joint injury in a mammal, and for inducing differentiation of mesenchymal stem cells into chondrocytes.

Abstract: A system architecture for linking one or more derived objects to existing data objects in a data structure can be organized in a variety of forms. A method for establishing the architecture may include linking first and second data objects. linking first and second data objects. The first and second data objects may be associated with corresponding first and second pluralities of properties. The method may include receiving a first user limitation associated with at least one of the first or second pluralities of properties and receiving a second user limitation associated with at least one of the first or second pluralities of properties. The method can include deriving a conclusion object comprising a third plurality of properties comprising a subset of one or more of the first or second pluralities of properties and linking the conclusion object to the first and second data objects.

Abstract: An electronic device obtains a plurality of collections of media content items, each collection of media content items being associated with text. Based on how frequently a first media content item co-occurs with a first descriptor in text for respective collections of media items that include the first media content item, the electronic device generates, without user input, a new collection of media content items for a first user. The new collection of media content items corresponds to the first descriptor and includes the first media content item. The electronic device presents the new collection of media content items to the first user as a recommendation.

Abstract: Systems and methods are disclosed that include an electronic device and an activation device. The electronic device includes a battery compartment having a battery storage section and a battery engagement section. The battery engagement section includes battery contacts. The electronic also includes a battery disposed in the battery storage section of the battery compartment. The battery moves from the battery storage section to the battery engagement section in response to an activation event to place the battery in electrical contact with the battery contacts. The activation device includes an activation element configured to generate the activation event.

Abstract: In-place recovery of fatal system errors at virtualization hosts. A device identifies an occurrence of a fatal system error in the first instance of a host operating system (OS) executing in a computer system. The device determines to perform an in-place recovery for the fatal system error. The device performs the in-place recovery, including pausing the execution of a virtual machine (VM) by the first instance of the host OS, preserving a state of the VM within system memory of the computer system, and resuming the execution of the VM by a second instance of the host OS executing in the computer system based on the state of the VM that is preserved within the system memory of the computer system.

Abstract: Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a user equipment (UE) may initiate a first service associated with a first subscriber identity module (SIM) of the UE and a first priority. The UE may initiate a second service associated with a second SIM of the UE and a second priority. The UE may switch the first priority and the second priority during at least part of the first service or the second service. The UE may perform a communication in accordance with at least one of the first priority or the second priority. Numerous other aspects are described.

Abstract: Provided are a video processing method and apparatus, an electronic device, a storage medium and a program product. The method includes steps described below. A to-be-processed video is acquired, and a first face key point of a first target object in the to-be-processed video is recognized, where the first face key point corresponds to a mask key point in a three-dimensional human face mask effect; and the three-dimensional human face mask effect is added to video frames of the to-be-processed video to obtain a target video, where the mask key point in the three-dimensional human face mask effect moves with the corresponding first face key point.

Abstract: The present invention relates to Ras inhibitors, intermediates in the synthesis thereto, and methods for preparing the Ras inhibitors and the intermediates.

Abstract: The disclosed technology provides techniques, systems, and apparatus for proactively detecting, containing, and recovering from uncorrectable memory errors in distributed computing environment. An aspect of the disclosed technology includes scanning, by a scanner of a host machine, memory of the host machine for errors. After the scanner detects an error, the scanner may generate an error notification. The scanner may transmit the error notification to one or more processors of the host machine to implement mitigation techniques.

Abstract: Embodiments of the disclosure relate to methods for selectively removing metal material from the top surface and sidewalls of a feature. The metal material which is covered by a flowable polymer material remains unaffected. In some embodiments, the metal material is formed by physical vapor deposition resulting in a relatively thin sidewall thickness. Any metal material remaining on the sidewall after removal of the metal material from the top surface may be etched by an additional etch process. The resulting metal layer at the bottom of the feature facilitates selective metal gapfill of the feature.

Abstract: A vehicle can include various sensors to detect objects in an environment. In some cases, the object may be within a planned path of travel of the vehicle. In these cases, leaving the planned path may be dangerous to the passengers so the vehicle may, based on dimensions of the object, dimensions of the vehicle, and semantic information of the object, determine operational parameters associate with passing the object while maintaining a position within the planned path, if possible.

Abstract: Devices, systems, and methods for social behavior of a telepresence robot are disclosed herein. A telepresence robot includes a drive system configured to move the telepresence robot; a control system configured to control the drive system to drive the telepresence robot around a work area; an object detection system configured to determine that a first object encountered by the telepresence robot is a human; and a social path component configured to: determine a first lockout zone having a first radius around the human and a first comfort zone having a second radius around the human, the second radius being larger than the first radius; and instruct the control system to cause the telepresence robot to: avoid traveling through the first lockout zone; move at a first maximum speed within the first comfort zone; and move at a second maximum speed outside of the first comfort zone, wherein the second maximum speed is greater than the first maximum speed.

Abstract: Disclosed is a data fabric service system that can be implemented in a distributed computer network, such as a data intake and query system. The data index and query system can receive a search query and define a search scheme for applying the search query on distributed data storage systems including internal data storage and external data storage. The data index and query system may provide a portion of the search scheme to a search service of the data fabric service system, which can cause worker nodes of the data fabric service system to perform various functions-including applying the search query to the external data storage based on the portion of the search scheme in order to obtain search results.

Abstract: Nucleotide sequences are disclosed that encode novel chimeric insecticidal proteins exhibiting Lepidopteran inhibitory activity. Particular embodiments provide compositions and transformed plants, plant parts, and seeds containing the recombinant nucleic acid molecules encoding one or more of the chimeric insecticidal proteins.

Abstract: Techniques for repairing a network failure in a Passive Optical Network (PON) include establishing a communication session with an optical network terminal (ONT) in a PON via a short-range communication link. In response to establishing the communication session, the techniques include receiving diagnostic information related to a network failure corresponding to the ONT, and presenting the diagnostic information to a user for the user to repair the ONT based on the received diagnostic information.

Abstract: In various embodiments, single-crystal aluminum nitride boules and substrates have low Urbach energies and/or absorption coefficients at deep-ultraviolet wavelengths. The single-crystal aluminum nitride may function as a platform for the fabrication of light-emitting devices such as light-emitting diodes and lasers. The single-crystal aluminum nitride boules may advantageously have diameters that increase along at least portions of their lengths.