Abstract: A chair comprises a seat pan member, a seat back member having a lumbar support member, a lumbar support assembly operatively connected to the lumbar support member and configured for moving the lumbar support member, with respect to the seat pan member and the seat back member, between at least a first position and a second position, and an actuator configured to operate the lumbar support assembly for movement of the lumbar support member between at least the first position and the second position. When the lumbar support member is in the second position, the lumbar support member is positioned forwardly, in a direction toward the seated user's lower back, relative to the seat back member so as to enable the user to be seated forwardly on the seat pan member while being engaged with the lumbar support member.

Abstract: A chair comprises a seat pan member, a seat back member having a lumbar support member, a lumbar support assembly operatively connected to the lumbar support member and configured for moving the lumbar support member, with respect to the seat pan member and the seat back member, between at least a first position and a second position, and an actuator configured to operate the lumbar support assembly for movement of the lumbar support member between at least the first position and the second position. When the lumbar support member is in the second position, the lumbar support member is positioned forwardly, in a direction toward the seated user's lower back, relative to the seat back member so as to enable the user to be seated forwardly on the seat pan member while being engaged with the lumbar support member.

Abstract: The invention concerns compounds of Formula (I) or pharmaceutically-acceptable salts thereof, wherein R1, R2 and n have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use as anti-proliferative and/or cell-killing agents.

Abstract: Aspects of the invention include devices, systems, and methods for enhancing a user's sleep. A flexible frame supports a flow manifold which can be used in unison with adjoined or adjacently integrated supportive members utilized to create soft objects of various designs and materials. These types of objects can be in the form of a pillow, mattress topper, even a child's stuff animal and other various stationary and portable soft sided padded embodiments as disclosed in this application. These various designs and embodiments house an integrated flow delivery system which is delivers concentrated, pressurized, and or altered gaseous flowing elements in a controlled and fluidic manner as to help address certain types of sleeping and breathing issues during their resting and sleep states.

Abstract: The invention concerns compounds of Formula (I) or pharmaceutically-acceptable salts thereof, wherein R1, R2 and n have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use as anti-proliferative and/or cell-killing agents.

Abstract: A portable expandable device with a contracting mechanism which allows for many forms of recreational products and structures to be expanded, reinforced in the expanded shape, and then contracted easily to regain its portable form. The expansion means is exercised by the use of at least one of the following, resiliently extending, unfolding, inflating, as to become an expanding form which can then be easily retracted to the redeployed form. The retraction mechanism reverses the expansion process utilizing a mechanism which sequentially exerts the forces needed in the proper locations in order to ensure proper contraction. Disclosed embodiments utilized supplemental structural reinforcement of the expanded form through the use of joints, releasable interlocks, latching mechanisms, air bladders, to ensure the form is stable and usable. The objective being a stable structure with a rapid and easy deployment and a supplemental retraction means as to be easily transportable.

Abstract: A chair comprises a seat pan member, a seat back member having a lumbar support member, a lumbar support assembly operatively connected to the lumbar support member and configured for moving the lumbar support member, with respect to the seat pan member and the seat back member, between at least a first position and a second position, and an actuator configured to operate the lumbar support assembly for movement of the lumbar support member between at least the first position and the second position. When the lumbar support member is in the second position, the lumbar support member is positioned forwardly, in a direction toward the seated user's lower back, relative to the seat back member so as to enable the user to be seated forwardly on the seat pan member while being engaged with the lumbar support member.

Abstract: A chair includes a seat pan member, a movement support frame, and at least two movement support members operatively connected to the seat pan member and the movement support frame. The at least two movement support members are configured to support the seat pan member in a floating manner for dynamic movement with respect to the movement support frame in at least one degree of freedom in a horizontal seating plane.

Abstract: The invention concerns compounds of Formula (I) or pharmaceutically-acceptable salts thereof, wherein R1, R2 and n have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use as anti-proliferative and/or cell-killing agents.

Abstract: The invention concerns compounds of Formula (I) or pharmaceutically-acceptable salts thereof, wherein R1, R2 and n have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use as anti-proliferative and/or cell-killing agents.

Abstract: A chair includes a seat pan member, a movement support frame, and at least two movement support members operatively connected to the seat pan member and the movement support frame. The at least two movement support members are configured to support the seat pan member in a floating manner for dynamic movement with respect to the movement support frame in at least one degree of freedom in a horizontal seating plane.

Abstract: A chair includes a seat pan member, a movement support frame, and at least two movement support members operatively connected to the seat pan member and the movement support frame. The at least two movement support members are configured to support the seat pan member in a floating manner for dynamic movement with respect to the movement support frame in at least one degree of freedom in a horizontal seating plane.

Abstract: The invention concerns compounds of Formula (I) or pharmaceutically-acceptable salts thereof, wherein R1, R2 and n have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use as anti-proliferative and/or cell-killing agents.

Abstract: The invention concerns compounds of Formula (I) or pharmaceutically-acceptable salts thereof, wherein R1, R2 and n have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use as anti-proliferative and/or cell-killing agents.

Abstract: The invention concerns compounds of Formula (I) or pharmaceutically-acceptable salts thereof, wherein R1, R2 and n have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use as anti-proliferative and/or cell-killing agents.

Abstract: The invention concerns compounds of Formula (I) (Formula (I)) or pharmaceutically-acceptable salts thereof, wherein R1, R2 and n have any of the meanings defined herein before in the description; processes for their preparation, pharmaceutical compositions containing them and their use as anti-proliferative and/or cell-killing agents.

Abstract: The invention concerns compounds of Formula (I) (Formula (I)) or pharmaceutically-acceptable salts thereof, wherein R1, R2 and n have any of the meanings defined herein before in the description; processes for their preparation, pharmaceutical compositions containing them and their use as anti-proliferative and/or cell-killing agents.

Abstract: A chair includes a seat pan member, a movement support frame, and at least two movement support members operatively connected to the seat pan member and the movement support frame. The at least two movement support members are configured to support the seat pan member in a floating manner for dynamic movement with respect to the movement support frame in at least one degree of freedom in a horizontal seating plane.

Abstract: Disclosed herein is a shredder having a device located at least partially between a shredder mechanism and an output side of the shredder housing to disperse any accumulation of shredded materials at least adjacent the output opening, as well as remove shredded materials caught in or near the cutting assembly. One device is a movable device positioned between a shredder mechanism and the output side of the shredder housing that is configured to pivot about an axis in an oscillating manner. Another device includes a fan mechanism for blowing and moving shredded materials through a passageway in the shredder housing and towards an outlet.

Abstract: A point-of-care, screening kit for use by a heath care worker to create custom test strips for screening the bodily fluids of an individual for various, medical conditions includes: (a) a plurality of reagents (12), (b) a substrate (18) configured to: i) receive one of the reagents and react with it so as to cause it to acquire a first characteristic color, and, ii) upon the addition of the individual's bodily fluid to the substrate, acquire, as a result of the formulation of each of the reagents, a second, dichotomous characteristic color when the individual has a specific one of the various, medical conditions.