Abstract: Provided herein are novel antibody-agent conjugates formed by the introduction of methionine residues to antibody scaffold light or heavy chains at select positions, followed by conjugation of the agent to the methionine, for example, by oxaziridine chemistries. Methionine substitutions at the targeted positions enable highly efficient functionalization to form very stable conjugates, including conjugates suitable for in vivo use. The positions were identified for the trastuzumab and other related scaffolds which can be engineered for affinity to any target antigen. The conjugates include ADCs and detections agents. Also disclosed are novel oxaziridine reagents for conjugation to methionines in proteins.

Abstract: Photocatalysts for activating multiple photoreactive probes and methods of proximity labeling proteins on a cell surface using same.

Abstract: Circuitry for processing a response from an electrochemical cell to a stimulus, the circuitry comprising: sense circuitry configured to measure the response of the electrochemical cell to the stimulus; and processing circuitry configured to: sample the measured response to obtain a plurality of samples; and output the plurality of samples, wherein the processing circuitry is operable in: a continuous sampling mode in which the processing circuitry is configured to periodically sample the measured response at a fixed sampling rate; a discontinuous sampling mode in which the processing circuitry is configured to periodically sample the measured response during macro periods separated by macro intervals during which sampling of the measured response is disabled.

Abstract: Circuitry for processing an analyte signal obtained from an electrochemical cell, the circuitry comprising: measurement circuitry having a first measurement input coupled to a first electrode of the electrochemical cell, the measurement circuitry configured to convert the analyte signal at the first measurement input to a first analog output signal; an analog-to-digital converter (ADC) having an first ADC input for receiving the first analog output signal, the ADC configured to convert the first analog output signal to a first digital output signal at an ADC output; compensation circuitry configured in a measurement mode to: apply a first compensation to the first digital output signal to obtain a first compensated digital output signal, the first compensation to compensate for non-linearity in the ADC; and apply a second compensation to the first compensated digital output signal to obtain a second compensated digital output signal, the second compensation to compensate for non-linearity in the measurement c

Abstract: Circuitry for processing an analyte signal obtained from an electrochemical cell, the circuitry comprising: measurement circuitry having a first measurement input coupled to a first electrode of the electrochemical cell, the measurement circuitry configured to convert the analyte signal at the first measurement input to a first analog output signal; an analog-to-digital converter (ADC) having an first ADC input for receiving the first analog output signal, the ADC configured to convert the first analog output signal to a first digital output signal at an ADC output; compensation circuitry configured in a measurement mode to: apply a first compensation to the first digital output signal to obtain a first compensated digital output signal, the first compensation to compensate for non-linearity in the ADC; and apply a second compensation to the first compensated digital output signal to obtain a second compensated digital output signal, the second compensation to compensate for non-linearity in the measurement c

Abstract: A measurement system comprising: power converter circuitry; and measurement circuitry, wherein the measurement circuitry is operative to control a timing of a refresh of the power converter circuitry so as to avoid conflict with a measurement operation.

Abstract: Examples described herein include systems and methods for dynamically determining a server for enrollment with a management system. An example method can include receiving user input at an application executing on a user device, such as a portal application that provides access to and authentication for other applications through a catalogue of application icons. If the user input includes a first URL but that URL produces an error when used in conjunction with extensions associated with a management server, the application can automatically use extensions associated with an application-support server. The application can then retrieve a second URL from the application-support server and use it for performing enrollment steps at the management server. The enrollment steps can include authenticating the user at an identity service and determining the user's group ID for enrollment, for example.

Abstract: The disclosure provides antibodies that specifically bind to a cleaved CDCP1 and antigen binding fragments thereof and methods of use thereof. In some aspects, the disclosure is directed to methods of treating a cancer in a subject, comprising administering to the subject an antibody or antigen-binding fragment thereof that specifically binds to a cleaved human CDCP1.

Abstract: Circuitry for processing an analyte signal obtained from an electrochemical cell, the circuitry comprising: measurement circuitry having a first measurement input coupled to a first electrode of the electrochemical cell, the measurement circuitry configured to convert the analyte signal at the first measurement input to a first analog output signal; an analog-to-digital converter (ADC) having an first ADC input for receiving the first analog output signal, the ADC configured to convert the first analog output signal to a first digital output signal at an ADC output; compensation circuitry configured in a measurement mode to: apply a first compensation to the first digital output signal to obtain a first compensated digital output signal, the first compensation to compensate for non-linearity in the ADC; and apply a second compensation to the first compensated digital output signal to obtain a second compensated digital output signal, the second compensation to compensate for non-linearity in the measurement c

Abstract: Circuitry for processing an analyte signal obtained from an electrochemical cell, the circuitry comprising: a first signal path between a first electrode of the electrochemical cell and a first input of an analog-to-digital converter (ADC) circuit, the first signal path comprising a first gain stage configured to convert the analyte signal to a first analog signal; a second signal path between the first electrode and a second input of the ADC circuit, the second signal path comprising a second gain stage configured to convert the analyte signal to a second analog signal; and switching circuitry configured to selectively couple the first electrode to the first input of the ADC circuit.

Abstract: Circuitry for processing a response from an electrochemical cell to a stimulus, the circuitry comprising: sense circuitry configured to measure the response of the electrochemical cell to the stimulus; and processing circuitry configured to: sample the measured response to obtain a plurality of samples; and output the plurality of samples, wherein the processing circuitry is operable in: a continuous sampling mode in which the processing circuitry is configured to periodically sample the measured response at a fixed sampling rate; a discontinuous sampling mode in which the processing circuitry is configured to periodically sample the measured response during macro periods separated by macro intervals during which sampling of the measured response is disabled.

Abstract: The present invention relates, inter alia, to a method of preventing or treating skin cancer or skin precancer, the method comprising locally administering to the skin of a subject in need thereof an effective amount of a compound of Formula (I) or a pro-drug thereof, Formula (I) wherein the subject is being administered an immunosuppressant agent that binds to FKBP12. The agent that binds to FKBP12 may be tacrolimus. The invention also relates to methods of preventing or treating a skin condition, disorder or disease associated with administration of an immunosuppressant agent that binds to FKBP12, and to uses of the compound of Formula (I) in treating skin cancer or skin precancer, or a skin condition, disorder or disease associated with administration of an immunosuppressant agent that binds to FKBP12.

Abstract: Examples described herein include systems and methods for dynamically displaying features in a GUI of a portal application that facilitates access to other applications. An example method can include receiving a push notification, from a notification service, at a user device upon which the portal application is installed. The push notification can indicate that a new feature is available for the portal application executing on the user device. The example method can include requesting, from the management server, at least one command for modifying the GUI of the portal application. The management server can provide the command or provide instructions for the user device to retrieve the command. The method can include receiving at least one command. The method can also include modifying the GUI of the portal application based on the received command and displaying the modified GUI.

Abstract: The present disclosure relates to self-test circuitry for a system that includes one or more current control subsystems, each current control subsystem having a load terminal for coupling the current control subsystem to a load. The self-test circuitry comprises: a signal path associated with each current control subsystem, each signal path configured to selectively couple a measurement node to the load terminal of the current control subsystem, wherein the measurement node is common to all of the signal paths; voltage detection circuitry; and test voltage source circuitry configured to provide a test voltage to the measurement node. The voltage detection circuitry is operable to output a signal indicative of a fault condition if a voltage detected at the measurement node differs from the test voltage when the measurement node is coupled to the load terminal.

Abstract: Examples described herein include systems and methods for dynamically displaying features in a GUI of a portal application that facilitates access to other applications. An example method can include receiving a push notification, from a notification service, at a user device upon which the portal application is installed. The push notification can indicate that a new feature is available for the portal application executing on the user device. The example method can include requesting, from the management server, at least one command for modifying the GUI of the portal application. The management server can provide the command or provide instructions for the user device to retrieve the command. The method can include receiving at least one command. The method can also include modifying the GUI of the portal application based on the received command and displaying the modified GUI.

Abstract: Provided herein are novel antibody-agent conjugates formed by the introduction of methionine residues to antibody scaffold light or heavy chains at select positions, followed by conjugation of the agent to the methionine, for example, by oxaziridine chemistries. Methionine substitutions at the targeted positions enable highly efficient functionalization to form very stable conjugates, including conjugates suitable for in vivo use. The positions were identified for the trastuzumab and other related scaffolds which can be engineered for affinity to any target antigen. The conjugates include ADCs and detections agents. Also disclosed are novel oxaziridine reagents for conjugation to methionines in proteins.

Abstract: The instant disclosure relates to methods for converting mammalian definitive endoderm (DE) cells into specific tissue(s) or organ(s) through directed differentiation. In particular, the disclosure relates to formation of gastric fundus tissue and/or organoids formed from differentiated definitive endoderm.

Abstract: Examples described herein include systems and methods for dynamically determining a server for enrollment with a management system. An example method can include receiving user input at an application executing on a user device, such as a portal application that provides access to and authentication for other applications through a catalogue of application icons. If the user input includes a first URL but that URL produces an error when used in conjunction with extensions associated with a management server, the application can automatically use extensions associated with an application-support server. The application can then retrieve a second URL from the application-support server and use it for performing enrollment steps at the management server. The enrollment steps can include authenticating the user at an identity service and determining the user's group ID for enrollment, for example.

Abstract: Examples described herein include systems and methods for dynamically displaying features in a GUI of a portal application that facilitates access to other applications. An example method can include receiving a push notification, from a notification service, at a user device upon which the portal application is installed. The push notification can indicate that a new feature is available for the portal application executing on the user device. The example method can include requesting, from the management server, at least one command for modifying the GUI of the portal application. The management server can provide the command or provide instructions for the user device to retrieve the command. The method can include receiving at least one command. The method can also include modifying the GUI of the portal application based on the received command and displaying the modified GUI.

Abstract: Examples described herein include systems and methods for dynamically determining a server for enrollment with a management system. An example method can include receiving user input at an application executing on a user device, such as a portal application that provides access to and authentication for other applications through a catalogue of application icons. If the user input includes a first URL but that URL produces an error when used in conjunction with extensions associated with a management server, the application can automatically use extensions associated with an application-support server. The application can then retrieve a second URL from the application-support server and use it for performing enrollment steps at the management server. The enrollment steps can include authenticating the user at an identity service and determining the user's group ID for enrollment, for example.