Abstract: A temperature-controlled shipper may comprise a temperature-controlled enclosure, a tray, an outer enclosure, and a lid, wherein the tray may be securely coupled to the temperature-controlled enclosure to resist tampering with a payload located in the temperature-controlled enclosure. The secure coupling of the temperature-controlled enclosure and the tray may be achieved using securely fastened or attached loops on both the temperature-controlled enclosure and the tray, wherein each tamper-resistant tie is secured after looping through one loop on the temperature-controlled enclosure and one loop on the tray to prevent access to the payload.

Abstract: Hardened reusable shipping containers (e.g., shippers) are disclosed herein. A shipper may have a base enclosure that is configured to receive a payload and maintain a temperature of an environment surrounding the payload. The shipper may have various features such as bosses, compartments, and surface features to facilitate protection of a dewar inside the base enclosure, and retention of a payload during shipment. The shipper may have various features to facilitate ready stacking of shippers and suitability for use in air cargo operations.

Abstract: Hardened reusable shipping containers with a reversible label holder and methods of using the same are disclosed herein. A hardened reusable shipping container may have a base enclosure having a payload area that is configured to receive a payload and maintain a temperature of an environment surrounding the payload. The base enclosure may further have an exterior surrounding the payload area. The exterior may include multiple walls. One of the multiple walls may define a recess. The hardened reusable shipping container may have a plate having a first surface and a second surface opposing the first surface. The plate may be configured to be removably inserted into the recess and display one or more visuals on at least one of the first surface and the second surface.