Abstract: The present application provides BCMA targeting chimeric antigen receptor (CAR) comprising a BCMA binding region and an intracellular costimulatory domain derived from DAP10. Further provided are engineered immune effector cells (such as NK cells) comprising the chimeric antigen receptors. Pharmaceutical compositions, kits and methods of treating cancer are also provided.

Abstract: Described herein are various fluid provision systems that may be used in a laboratory setting. The fluid provision systems minimize waste of pipetted liquid sample or reagents and may be used, e.g., in combination with a multi-well plate such as in NGS processes. Other systems include those configured for compatibility with centrifuge rotors or multichannel pipettes with 12 or more channels.

Abstract: A sensor for a flexible sensor assembly includes a drive coil, a first set of sensing coils, a second set of sensing coils, and a configuration for sensing for discontinuities in a structure desired to be sensed. A method of operating the sensor can include positioning the sensor proximate to the structure, energizing the drive coil, and sensing eddy currents with the sensing coils.

Abstract: This document describes an automated external defibrillator comprising a control configured to switch between a pediatric operating mode and an adult operating mode, wherein each operating mode comprises a mode-specific energy configuration and a mode-specific user configuration; an indicator configured to provide an indication of the operating mode in use during a resuscitation process; one or more processors configured to switch to the mode-specific energy configuration and the mode-specific user configuration upon a change of operating mode between the pediatric operating mode and the adult operating mode such that the automated external defibrillator delivers a defibrillating shock to a patient based on the mode-specific energy configuration; and an interface of the automated external defibrillator provides resuscitation instructions to a user based on the mode-specific user configuration.

Abstract: Processes to prepare aqueous polymer dispersions are provided, as well as compositions thereof, which have high solids content (e.g., 50%) with low viscosity. The process uses a selective hydrophilic macro-RAFT agent of formula (I), and is substantially free of surfactants. This process can be used to make latex polymers with good stability, which can be used widely in coatings (e.g., architectural paints, stone paints, industrial coatings, wood coatings, etc.), adhesives, sealants and mastic compositions.

Abstract: A ladder platform device for defining a work surface on a ladder includes a platform that has a central panel extending between a pair of outward panels. The central panel is positionable upon a topmost step of a ladder such that each of the pair of outward panels defines a work surface to support tools and other objects. Each of the pair of outward panels has a recess to retain the tools and other objects on the outward panels. A plurality of hooks is provided and each of the plurality of hooks is removably attachable to a respective one of the pair of outward panels to suspend a tool from the respective outward panel.

Abstract: The present invention relates to new cationic polymers, a synthesis process for preparing them from urea diamine condensates and polyepoxide derivatives, notably bisepoxide derivatives, and to the use of said new cationic polymers for surface treatment applications including, but not limited to, home and personal care applications as well as industrial and institutional cleaning applications.

Abstract: The present invention relates to new cationic polymers, a synthesis process for preparing them from monourea diamine condensates and bifunctional ether derivatives, notably dihalogeno ether derivatives, and to the use of said new cationic polymers for surface treatment applications including, but not limited to, home and personal care applications as well as industrial and institutional cleaning applications.

Abstract: The present invention relates to new cationic polymers, a synthesis process for preparing them from polyurea diamine condensates and bifunctional ether derivatives, notably dihalogeno ether derivatives, and to the use of said new cationic polymers for surface treatment applications including, but not limited to, home and personal care applications as well as industrial and institutional cleaning applications.

Abstract: The invention pertains to a process for polymerizing fluoromonomers in the presence of a certain amphiphilic reversible addition fragmentation chain transfer (RAFT) agent.

Abstract: A casing running rotary insert can include a base having a first aperture that traverses therethrough. The casing running rotary insert can also include a rotary table engagement feature that extends from a bottom surface of the base, where the rotary table engagement feature is configured to engage a complementary feature of a rotary table to fix a position of the base relative to the rotary table, and where the aperture in the base is configured to align with a second aperture in the rotary table when the rotary table engagement feature is engaged with the complementary feature of the rotary table. The casing running rotary insert can further include a casing bowl engagement feature that extends from a top surface of the base, where the casing bowl engagement feature is configured to engage a casing bowl to fix a position of the casing bowl relative to the base.

Abstract: An electrode arrangement for use with a system for performing measurements on a biological subject, the electrode arrangement including: at least one substrate; and, a plurality of plate microstructures extending from the substrate, the microstructures being configured to breach the stratum corneum of the subject and wherein the microstructures include electrodes to allow signals to be applied to and/or received from the subject via the microstructures.

Abstract: The present invention relates to a binder for a non-aqueous electrolyte rechargeable battery, a negative electrode slurry for a rechargeable battery, a negative electrode for a rechargeable battery, and a rechargeable battery comprising the same.

Abstract: The present invention relates to a polymer for a non-aqueous electrolyte rechargeable battery, an electrode slurry for a rechargeable battery and a rechargeable battery comprising the same.

Abstract: The present invention relates to a binder for a non-aqueous electrolyte rechargeable battery, a negative electrode slurry for a rechargeable battery, a negative electrode for a rechargeable battery, and a rechargeable battery comprising the same.

Abstract: A method of processing products in a retort having a length includes arranging products in at least one product carrier for movement along at least a portion of the length of the retort and reciprocating the at least one product carrier along at least a portion of the length of retort in a non-sinusoidal pattern of movement.

Abstract: A device for dissolving a gas in a liquid is provided, the device comprising a device body, the device body comprising a liquid inlet; a liquid outlet; a plurality of substantially conical dissolving chambers located between the liquid inlet and the liquid outlet. The device may comprise a plurality of chamber connectors of or connected with the dissolving chambers. Each of the plurality of conical dissolving chambers may comprise a wider end towards the liquid outlet, the wider end comprising a chamber outlet for flow of liquid out of the dissolving chamber; and a narrower end towards the liquid inlet, the narrower end comprising a chamber inlet for flow of liquid into the dissolving chamber. The plurality of chamber connectors may define a substantially longitudinally straight passage extending through the plurality of dissolving chambers. Also provided is a related method of dissolving a gas in a liquid.

Abstract: Example embodiments relate to a method for training a predictive model from data. The method includes defining a multitude of predicates as binary functions operating on time sequences of the features or logical operations on the time sequences of the features. The method also includes iteratively training a boosting model by generating a number of new random predicates, scoring all the new random predicates by weighted information gain with respect to a class label associated with a prediction of the boosting model, selecting a number of the new random predicates with the highest weighted information gain and adding them to the boosting model, computing weights for all the predicates in the boosting model, removing one or more of the selected new predicates with the highest information gain from the boosting model in response to input from an operator. The method may include repeating the prior steps a plurality of times.