Publication number: 20100184786
Abstract: Disclosed are polar quinazoline-based modulators of Liver X receptors (LXRs) and related methods. The modulators include compounds of formula (I): in which, R1, R2, R3, R4, R5, R6, R22, R23, R24, R25, R26, R27, R28, R29, W, W1, W2, Ra, Rb, Rc, Rd, Re, Rf, Rg, Rh, Ri, Rj, Rm, Rn, Ro, Rp, Rq, Rr, Rs, Rt, Ru, and n can be as defined anywhere herein. In general, these compounds can be used for treating or preventing one or more diseases, disorders, conditions or symptoms mediated by LXRs.
Type:
Application
Filed:
November 19, 2009
Publication date:
July 22, 2010
Applicant:
Wyeth LLC
Inventors:
Jeremy Mark Travins, Ronald Charles Bernotas, Jay Edward Wrobel, David Harry Kaufman, Baihua Hu, James Winfield Jetter, David John O'Neill, Charles William Mann