Patents by Inventor James Winkler
James Winkler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11967488Abstract: A system and method for treating a deposition reactor are disclosed. The system and method remove or mitigate formation of residue in a gas-phase reactor used to deposit doped metal films, such as aluminum-doped titanium carbide films or aluminum-doped tantalum carbide films. The method includes a step of exposing a reaction chamber to a treatment reactant that mitigates formation of species that lead to residue formation.Type: GrantFiled: May 16, 2022Date of Patent: April 23, 2024Assignee: ASM IP Holding B.V.Inventors: Suvi Haukka, Eric James Shero, Fred Alokozai, Dong Li, Jereld Lee Winkler, Xichong Chen
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Patent number: 11946136Abstract: A semiconductor processing device is disclosed. The device can include a reactor and a solid source vessel configured to supply a vaporized solid reactant to the reactor. A process control chamber can be disposed between the solid source vessel and the reactor. The device can include a valve upstream of the process control chamber. A control system can be configured to control operation of the valve based at least in part on feedback of measured pressure in the process control chamber.Type: GrantFiled: September 8, 2020Date of Patent: April 2, 2024Assignee: ASM IP Holding B.V.Inventors: Jereld Lee Winkler, Eric James Shero, Carl Louis White, Shankar Swaminathan, Bhushan Zope
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Publication number: 20090162941Abstract: The present invention relates to methods and devices for air ingestion prevention. The invention provides a stopper or plug with one or more conduits and a recess that prevents air ingestion during outlet of a liquid from a liquid container covered with the stopper.Type: ApplicationFiled: December 21, 2007Publication date: June 25, 2009Inventors: James Winkler, Robyn Bennis, Lou Dietz, Keith Moravick, Haile Negussie
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Publication number: 20060234267Abstract: A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360 for introducing selected fluids into the cavity to contact the probes. Accordingly, a commercially feasible device for use in high throughput assay systems is provided.Type: ApplicationFiled: March 20, 2006Publication date: October 19, 2006Applicant: AFFYMETRIX, INCInventors: Donald Besemer, Virginia Goss, James Winkler
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Publication number: 20060210452Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.Type: ApplicationFiled: August 25, 2005Publication date: September 21, 2006Inventors: Stephen Fodor, Lubert Stryer, James Winkler, Christopher Holmes, Dennis Solas
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Publication number: 20060040380Abstract: A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360 for introducing selected fluids into the cavity to contact the probes. Accordingly, a commercially feasible device for use in high throughput assay systems is provided.Type: ApplicationFiled: October 26, 2005Publication date: February 23, 2006Applicant: Affymetrix, INC.Inventors: Donald Besemer, Virginia Goss, James Winkler
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Publication number: 20050281708Abstract: In accordance with various embodiments of the invention, an apparatus is provided for hybridizing a nucleic acid microarray immobilized on a surface of a solid substrate. The apparatus comprises at least one assembly for securing the solid substrate during hybridization, the assembly comprising a carrier and a cover having a surface facing the carrier. The carrier and the cover can be dimensioned to receive the solid substrate between the carrier and the surface of the cover so that the surfaces of the cover and the solid substrate define a cavity. In some embodiments, the apparatus can include a fluid control module comprising a manifold, at least one liquid reservoir, at least one waste container, and a vacuum source in fluid communication with the waste container. The manifold can provide fluid communication between the liquid reservoir and the cavity and between the cavity and the waste container, and the vacuum source can provide a pressure difference between the liquid reservoir and the waste container.Type: ApplicationFiled: July 7, 2005Publication date: December 22, 2005Applicant: Affymetrix, Inc.Inventors: Mark Trulson, James Winkler, Maureen Cronin, David Stern
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Publication number: 20050247887Abstract: In accordance with various embodiments of the invention, an apparatus is provided for hybridizing a nucleic acid microarray immobilized on a surface of a solid substrate. The apparatus comprises at least one assembly for securing the solid substrate during hybridization, the assembly comprising a carrier and a cover having a surface facing the carrier. The carrier and the cover can be dimensioned to receive the solid substrate between the carrier and the surface of the cover so that the surfaces of the cover and the solid substrate define a cavity. In some embodiments, the apparatus can include a fluid control module comprising a manifold, at least one liquid reservoir, at least one waste container, and a vacuum source in fluid communication with the waste container. The manifold can provide fluid communication between the liquid reservoir and the cavity and between the cavity and the waste container, and the vacuum source can provide a pressure difference between the liquid reservoir and the waste container.Type: ApplicationFiled: July 7, 2005Publication date: November 10, 2005Applicant: Affymetrix, Inc.Inventors: Mark Trulson, James Winkler, Maureen Cronin, David Stern
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Publication number: 20050215468Abstract: The invention provides a method of reducing the damage done by reactive oxygen species (ROS) in an animal. The invention also provides a method of reducing the concentration of a metal in an animal. These methods comprise administering to the animal an effective amount of a metal-binding compound as further described in the application. The invention further provides a method of reducing the damage done by ROS to a cell, a tissue or an organ that has been removed from an animal. This method comprising contacting the cell, tissue or organ with a solution or medium containing an effective amount of a metal-binding compound of the invention. The invention further provides novel metal-binding compounds, pharmaceutical compositions comprising the metal-binding compounds, and kits comprising a container holding a metal-binding compound of the invention.Type: ApplicationFiled: July 19, 2004Publication date: September 29, 2005Inventors: David Bar-Or, C. Curtis, Edward Lau, Nagaraja Rao, James Winkler, Wannell Crook
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Publication number: 20050208646Abstract: A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360 for introducing selected fluids into the cavity to contact the probes. Accordingly, a commercially feasible device for use in high throughput assay systems is provided.Type: ApplicationFiled: November 22, 2004Publication date: September 22, 2005Applicant: Affymetrix, INC.Inventors: Donald Besemer, Virginia Goss, James Winkler
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Publication number: 20050191630Abstract: A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360 for introducing selected fluids into the cavity to contact the probes. Accordingly, a commercially feasible device for use in high throughput assay systems is provided.Type: ApplicationFiled: August 11, 2003Publication date: September 1, 2005Applicant: AFFYMETRIX, INC., A Delaware Corporation.Inventors: Donald Besemer, Virginia Goss, James Winkler
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Publication number: 20050186592Abstract: A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.Type: ApplicationFiled: November 24, 2004Publication date: August 25, 2005Applicants: Affymetrix, Inc., AFFYMAX TECHNOLOGIES N.V.Inventors: James Winkler, Stephen Fodor, Christopher Buchko, Debra Ross, Lois Aldwin, Douglas Modlin
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Publication number: 20050186683Abstract: A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.Type: ApplicationFiled: November 24, 2004Publication date: August 25, 2005Applicants: Affymetrix, Inc., AFFYMAX TECHNOLOGIES N.V.Inventors: James Winkler, Stephen Fodor, Christopher Buchko, Debra Ross, Lois Aldwin, Douglas Modlin
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Publication number: 20050158819Abstract: A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360 for introducing selected fluids into the cavity to contact the probes. Accordingly, a commercially feasible device for use in high throughput assay systems is provided.Type: ApplicationFiled: October 27, 2004Publication date: July 21, 2005Applicant: Affymetrix, INC.Inventors: Donald Besemer, Virginia Goss, James Winkler
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Publication number: 20050142613Abstract: The present invention relates to rapid methods for the detection of ischemic states and to kits for use in such methods. Provided for is a rapid method of testing for and quantifying ischemia based upon methods of detecting and quantifying the existence of an alteration of the serum protein albumin which occurs following an ischemic event; methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of circulating albumin, analysis and measurement of the ability of serum albumin to bind exogenous cobalt, detection and measurement of the presence of endogenous copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following an ischemic event.Type: ApplicationFiled: January 12, 2005Publication date: June 30, 2005Inventors: David Bar-Or, Edward Lau, James Winkler, Gary Fagan, Hollie Wayment
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Publication number: 20050124000Abstract: A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.Type: ApplicationFiled: November 24, 2004Publication date: June 9, 2005Applicants: Affymetrix, Inc., AFFYMAX TECHNOLOGIES N.V., a Netherlands Antilles corporationInventors: James Winkler, Stephen Fodor, Christopher Buchko, Debra Ross, Lois Aldwin, Douglas Modlin
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Publication number: 20050106615Abstract: A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360 for introducing selected fluids into the cavity to contact the probes. Accordingly, a commercially feasible device for use in high throughput assay systems is provided.Type: ApplicationFiled: November 17, 2004Publication date: May 19, 2005Applicant: Affymetrix, INC.Inventors: Donald Besemer, Virginia Goss, James Winkler
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Publication number: 20050106617Abstract: A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360 for introducing selected fluids into the cavity to contact the probes. Accordingly, a commercially feasible device for use in high throughput assay systems is provided.Type: ApplicationFiled: November 22, 2004Publication date: May 19, 2005Applicant: Affymetrix, INC., A Delaware CorporationInventors: Donald Besemer, Virginia Goss, James Winkler
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Publication number: 20050106618Abstract: A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360 for introducing selected fluids into the cavity to contact the probes. Accordingly, a commercially feasible device for use in high throughput assay systems is provided.Type: ApplicationFiled: December 16, 2004Publication date: May 19, 2005Applicant: Affymetrix, INC.Inventors: Donald Besemer, Virginia Goss, James Winkler
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Publication number: 20050089953Abstract: A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360 for introducing selected fluids into the cavity to contact the probes. Accordingly, a commercially feasible device for use in high throughput assay systems is provided.Type: ApplicationFiled: November 22, 2004Publication date: April 28, 2005Applicant: Affymetrix, INC.Inventors: Donald Besemer, Virginia Goss, James Winkler