Abstract: Clinical signage systems with reversible, reusable information cards with warnings, precautions, status, or other information printed on one side assembled into a card holder and methods for using same. The reversible signs can be selectively turned to make the warnings, precautions, or other information visible or hidden to tailor the signage to a particular patient or patient room condition or area of a medical facility. The clinical signage system provides a reliable and easy to use system for clear communication of patient or room or area conditions to healthcare professionals or visitors. The signage system is easy to clean and, with selective material choice, may be antibacterial to help prevent the spread of infectious diseases or contagions.