Abstract: Compositions and methods are provided for an inducible, high efficiency intra-genomic homologous recombination (IGHR) system in plants, that can be used for non-chimeric, heritable gene targeting. The advantage of IGHR approach to targeted integration is that every cell contains donor DNA and nuclease-encoding sequences, so that there are many potentially homology-directed targeting events that can occur during plant development.

Abstract: Methods, systems, and devices for performance control for a memory sub-system are described. A memory sub-system can monitor a backend for writing data to a memory device. The memory sub-system can determine that the bandwidth of the backend satisfies one or more performance criteria that are based on performance between the memory sub-system and a host system. In some embodiments, the memory sub-system can allocate a quantity of slots of a buffer to a frontend of the memory sub-system based on determining that the bandwidth of the backend satisfies the one or more performance criteria. Slots of the buffer can be configured to receive data from the frontend for writing to the memory device by the backend.

Abstract: Organometallic compounds comprising an imidazole carbene ligand having a N-containing ring fused to the imidazole ring are provided. In particular, the N-containing ring fused to the imidazole ring may contain one nitrogen atom or more than one nitrogen atom. These compounds may demonstrate high photoluminescent (PL) efficiency, Gaussian emission spectra, and/or short excited state lifetimes. These materials may be especially useful as blue phosphorescent emitters.

Abstract: A shower bar system for liquid soap supply comprises a soap dispenser assembly, a fixed base, a slide bar which is connected between the two, and an accessory which is coupled to the slide bar. The soap dispenser assembly includes a soap dispensing mechanism and two pivot mechanisms which are disposed respectively at the left side and the right side of the soap dispensing mechanism. Each of the pivot mechanisms is rotatably coupled to a rotary unit. An inner end of each of the rotary units has a connecting opening communicating with the soap dispensing mechanism. A peripheral surface of each of the rotary units is detachably coupled to a soap bottle. The liquid soap flown from each soap bottle to the soap dispenser assembly can be pressed out through the soap dispensing mechanism.

Abstract: The invention provides a CCR1 antagonist, or a pharmaceutically acceptable salt, hydrate or solvate thereof, for use in the treatment of pancreatic cancer, in particular a CCR1 antagonist, for example in combination with one or more further therapeutic agents effective as anti-tumour agents in the treatment of pancreatic cancer. Such an anti-tumour agent may be a chemotherapeutic agent selected from Gemcitabine, Fluorouracil (5-FU), Capecitabine, FOLFIRINOX (Leucovorin Calcium, Fluorouracil, Irinotecan Hydrochloride and Oxaliplatin), Nab-paclitaxel (Abraxane®) and combinations thereof. An immuno-oncology agent (e.g. a PD-1 inhibitor and/or a PD-L1 inhibitor) may also favourably be used with the CCR1 antagonist.

Abstract: New antibodies and methods of use are described.

Abstract: Orthodontic articles and polymerizable resin compositions are described. The orthodontic article comprises a cured composition comprising the reaction product of free-radically polymerizable resin comprising 30 to 70 wt. %, inclusive, of at least one urethane component, and 25 to 70 wt. %, inclusive, of reactive diluent(s) comprising at least one monofunctional (meth)acrylate monomer. The polymerizable resin comprises no greater than 35 wt. % of reactive diluent(s) having a high affinity for water. Reactive diluent(s) such as monofunctional (meth)acrylate monomers having a high affinity for water have low log P values. In one embodiment, the polymerizable resin comprises at least one acidic monomer.

Abstract: Embodiments of the disclosure are drawn to apparatuses, systems, methods for performing operations associated with machine learning. Machine learning operations may include processing a data set, training a machine learning algorithm, and applying a trained algorithm to a data set. Some of the machine learning operations, such as pattern matching operations, may be performed within a memory device.

Abstract: Kneading elements, extrusion apparatus, and methods of manufacturing honeycomb bodies are described herein. A kneading element (1802) has an inner surface (1804) defining an opening (1806) configured to couple the kneading element (1802) to a shaft (46,48). The kneading element (1802) also has a continuous closed curve elliptical outer surface (1808). The opening (1806) has an axis (1814) that is off-center with respect to a geometric center (1816) of the kneading element (1802) as viewed in a transverse plane perpendicular to the axis.

Abstract: Platform assembly for use with sorting articles comprises platforms connected to each other to form at least one level surface for transit thereabout by a plurality of vehicles. Each platform defines a first orientation in which the platform is in a retracted position and a second orientation in which the platform is in an extended position with a horizontal disposition. Each platform includes a first panel comprising a plurality of markers thereon, the markers forming a grid on the first panel for transit thereabout by the plurality of vehicles. Each marker includes a magnetic signature for determining an orientation of the marker. A container is positioned about at least one of the plurality of markers. In operation, the vehicle is directed by a control system to deposit an article carried thereon into a container associated with a marker based on the location and orientation of the marker.

Abstract: A radiation curable composition including at least one radiation hardenable component, a photo-initiator, and a filler material having a population of particulates in an amount greater than or equal to 50% by weight of the printable composition. The population of particulates exhibits a median diameter (D50) of greater than or equal to 0.3 micrometer on a volume-average basis as determined using the Particle Size Test Method, and the radiation curable composition exhibits a viscosity of less than or equal to 150 Pa s when measured using the Viscosity Test Method. A method, apparatus, and systems for producing composite articles by selectively exposing a portion of the radiation curable composition to a source of actinic radiation to at least partially cure the exposed portion of the radiation curable composition, thereby forming a hardened layer, preferably by an additive manufacturing process such as stereophotolithography, are also described. The composite articles may include composite dental restorations.

Abstract: Embodiments are directed to monitoring network traffic using network monitoring computers (NMCs). Networks may be configured to protect servers using centralized security protocols. Centralized security protocols may depend on centralized control provided by authentication control servers. If a client intends to access protected servers it may communicate with the authentication control server to obtain keys that enable it to access the requested servers. NMCs may monitor network traffic the centralized security protocol to collect metrics associated with the control servers, clients, or resource servers.

Abstract: A vacuum insulated cabinet structure includes panels having sheet metal outer side walls and polymer inner side walls. The polymer inner side walls are heat-sealed to a layer of polymer material laminated to a flat sheet metal blank to form vacuum cavities. The blank is then bent along fold lines to form a cabinet structure.

Abstract: A lighting shower includes a body, a lighting device, a control module, and a hydraulic power generating device. The body has a first portion and a second portion facing opposite directions and includes an inlet tube and an outlet cover plate disposed on the second portion. The lighting device includes a transparent cover disposed on the first portion and a light-emitting element disposed in the transparent cover. The control module includes a storage battery and a controller electrically connected to the light-emitting element and adapted to control the light-emitting element to turn on or turn off. The water flows into a first chamber of the body from the inlet tube and through the hydraulic power generating device out from the outlet cover plate. The hydraulic power generating device is electrically connected to the control module to output an electrical energy to the storage battery for storage for providing an electricity required by the lighting device.

Abstract: Methods, systems, and devices for data stream processing for maintaining queues for memory sub-systems are described. A number of commands included in a queue of a plurality of queues of a memory die of a memory sub-system can be determined. Each queue can be associated with a respective priority level and can be configured to maintain a respective set of commands. A command can be assigned to the queue based on a number of commands included in the queue. One or more commands can be issued from the queues based on the respective priority levels of the queues.

Abstract: Embodiments are directed to monitoring network traffic using network monitoring computers (NMCs). Metrics may be determined based on monitoring network traffic associated with a plurality of entities each associated with a profile that includes the metrics for each entity. Beaconing metrics associated with beaconing activity may be determined based on the metrics. The profile of each entity may be compared with the beaconing metrics to determine the entities that may be engaged in beaconing activity. The entities may be characterized based on beaconing activity such that the beaconing activity includes communication with endpoints associated with the third parties, employing communication protocols associated with the third-parties, or exchanging payloads consistent with the beaconing activity. Reports that include information associated with the entities and its beaconing activity may be generated.

Abstract: Methods, systems, and devices for managing queues of a memory sub-system are described. A first command can be assigned to a first queue of a memory die of a memory sub-system. The first queue can be is associated with a first priority level and the memory die can include a second queue associated with a second priority level different from the first priority level. The second queue can include a second command, where the first command and the second command are each associated with a respective operation to be performed on the memory sub-system. In some examples, the first command can be issued before the second command based on the first and second priority levels.

Abstract: Compounds, particles, and cathode active materials that can be used in lithium ion batteries are described herein. Methods of making such compounds, powders, and cathode active materials are described. The particles have a particle size distribution with a D50 ranging from 10 ?m to 20 ?m.

Abstract: The systems and methods may use machine learning models to process device data of user devices and determine device usage behaviors for the users of the user devices based on the device data. The systems and methods may provide relatable insights for the device usage behaviors in a user-friendly manner. The systems and methods may provide actional recommendations that users may take in response to the insights provided to promote healthy device usage behaviors or to prevent or reduce the device usage behavior. The systems and methods may also provide recommendations with access to information or other content related to the device usage behavior.

Abstract: Embodiments of the disclosure are drawn to apparatuses, systems, methods, and memories that are capable of performing pattern matching operations within a memory device. The pattern matching operations may be performed on data stored within the memory based on a pattern stored in a register. The result of the pattern matching operation may be provided by the memory. The data on which the pattern matching operation is performed may not be output from the memory during the pattern matching operation.