Abstract: A compound having the structure: wherein R1, R2, R, R, X, Y and Z are as defined herein. The compounds are estrogen receptor modulators useful for the treatment of proliferative disorders.

Abstract: A compound having the structure: wherein R1 and Z are as described above, X is selected from the group consisting of: C1-C6 alkyl, a substituted alkyl, a halogen, a halogenated alkyl, a glucuronide, —NH2, —SO2NH2, —COOH, —CN, —CH2CN, —NHCN, —CHO, —COOsalt, —OSO2alkyl, —SH, —SCH3—CH(CH2)nCOOCH3, —(CH2)n—O—CH3, —CH2OH, —(CH2)n—O—NH2, —NH(CH2)nCH3, NH(CH2)nOCH3, —NH(CH2)nCHOH—COOH, —N(CH3)2, —(CH2)n(NH)CH2OH, —NHCOOH, —(CH2)nNHCOOH, —NO2, —SCN, —SO2alkyl, —B(OH)2, —(CH2)nN(CH3)—SO2—NH3, —(CH2)nNH—SO2—NH2, —NHC(?S)CH3, and —NHNH2; R3 is selected from the group consisting of: H, a C1-C6 alkyl, a substituted alkyl, a halogen, and a halogenated alkyl; R4 and Y are independently selected from a group consisting of: O, —OH, —H, a —C1-C6 alkyl, a substituted alkyl, a halogen, a halogenated alkyl, a sulfate, a glucuronide, a bulky group, a phenyl or a substituted phenyl group, a cyclo- or heterocyclo group, piperidine, piperazine, morpholine, pyrimidine, —NH2, —N(CH2)nCH3; a phosphate group, a phosphinate group, whe

Abstract: A compound having the structure: wherein R1, R2, R3, R4, R5, R6, R7 and R9 are independently hydrogen, C1 to C6 alkyl or substituted alkyl, halogen, sulfate or glucuronide moieties; the symbol represents either a single or a double bond and when the symbol is a double bond and forms a keto group at position 3 or 17, then no R7 or R6 is present, respectively; the symbol represent the presence or absence of a bond at position 10; and the symbol represents any type of bond regardless of the stereochemistry. The invention also embraces the enantiomers, other stereochemical isomers, hydrates, solvates, tautomers and pharmaceutically acceptable salts of said compounds.

Abstract: 6-Methyloxaalkyl exemestane compounds and related compositions, as can be used, chemotherapeutically, to inhibit growth and proliferation of cancer cells.

Abstract: DNA segments encoding the Erwinia herbicola enzymes geranylgeranyl pyrophosphate (GGPP) synthase, phytoene synthase, phytoene dehydrogenase-4H and lycopene cyclase, vectors containing those DNA segments, host cells containing the vectors and methods for producing those enzymes and beta-carotene by recombinant DNA technology in transformed host organisms are disclosed.

Abstract: DNA segments encoding the Erwinia herbicola enzymes geranylgeranyl pyrophosphate (GGPP) synthase and phytoene synthase, vectors containing those DNA segments, host cells containing the vectors and methods for producing those enzymes and phytoene by recombinant DNA technology in transformed host organisms are disclosed.

Abstract: DNA segments encoding the Erwinia enzymes geranylgeranyl pyrophosphate (GGPP) synthase, phytoene synthase and phytoene dehydrogenase-4H, vectors containing those DNA segments, host cells containing the vectors and methods for producing those enzymes and lycopene by recombinant DNA technology in transformed host organisms are disclosed.

Abstract: DNA segments encoding the Erwinia herbicola enzymes geranylgeranyl pyrophosphate (GGPP) synthase, phytoene synthase, phytoene dehydrogenase-4H and lycopene cyclase, vectors containing those DNA segments, host cells containing the vectors and methods for producing those enzymes and beta-carotene by recombinant DNA technology in transformed host organisms are disclosed.