Abstract: The present invention relates generally to the field of using udenafil or a pharmaceutically acceptable salt thereof in patients who have undergone the Fontan operation.

Abstract: Approaches for facilitating spatial and temporal verification of users and/or user devices are disclosed. In some implementations, a user device may be detected within a short wireless communication range. A wireless communication session with the user device may be initiated based on the detection. Information identifying a first integrity-based certificate may be received from the user device during the wireless communication session during a first time period. Information identifying a second integrity-based certificate associated with a second time period may be provided responsive to determining that the first integrity-based certificate is a valid integrity-based certificate associated with the first time period. The second integrity-based certificate may be configured to allow network access for the user device during the second time period.

Abstract: Approaches for facilitating spatial and temporal verification of users and/or user devices are disclosed. In some implementations, a user device may be detected within a short wireless communication range. A wireless communication session with the user device may be initiated based on the detection. Information identifying a first integrity-based certificate may be received from the user device during the wireless communication session during a first time period. Information identifying a second integrity-based certificate associated with a second time period may be provided responsive to determining that the first integrity-based certificate is a valid integrity-based certificate associated with the first time period. The second integrity-based certificate may be configured to allow network access for the user device during the second time period.

Abstract: Approaches for facilitating spatial and temporal verification of users and/or user devices are disclosed. In some implementations, a user device may be detected within a short wireless communication range. A wireless communication session with the user device may be initiated based on the detection. Information identifying a first integrity-based certificate may be received from the user device during the wireless communication session during a first time period. Information identifying a second integrity-based certificate associated with a second time period may be provided responsive to determining that the first integrity-based certificate is a valid integrity-based certificate associated with the first time period. The second integrity-based certificate may be configured to allow network access for the user device during the second time period.

Abstract: Approaches for facilitating spatial and temporal verification of users and/or user devices are disclosed. In some implementations, a user device may be detected within a short wireless communication range. A wireless communication session with the user device may be initiated based on the detection. Information identifying a first integrity-based certificate may be received from the user device during the wireless communication session during a first time period. Information identifying a second integrity-based certificate associated with a second time period may be provided responsive to determining that the first integrity-based certificate is a valid integrity-based certificate associated with the first time period. The second integrity-based certificate may be configured to allow network access for the user device during the second time period.

Abstract: The invention provides methods of treatment for female sexual arousal disorder. In preferred embodiments, the invention provides methods of treatment with a semisolid composition suitable for topical application comprising: an effective amount of a vasoactive prostaglandin, a penetration enhancer, a polymer thickener, a lipophilic component, water and an acidic buffer system.

Abstract: A package having a recloseable pour spout is disclosed, with the package including front and rear package panels which may be joined at respective side edges thereof by inwardly extending side gussets. An upper edge portion of the package is removable, including one of the side gussets, to form a pour spout for dispensing the contents of the package. A fastener strip, which can be detachably connected to itself, extends between confronting inside surfaces of the front and rear package panels, adjacent to the pour spout, whereby the pour spout can be conveniently closed after the package is initially opened. The package can include a longitudinal seal which extends from adjacent the pour spout to overlap the fastener strip.

Abstract: Reclosable bags, plastic film for making the bags, and a method and apparatus for making the bags are disclosed. The bag has a reclosable fastener (26) connected to a single wall of the bag, and the film (55) has a reclosable fastener (26) connected to one side thereof which does not require attachment to any other portion of the film (55) when making a bag. The fastener (26) has a tamper-proof member attached thereto to indicate if the bag has been previously opened. The film (55) can be wound into a roll (54) suitable for use on conventional bag making machines including form, fill, and seal machines or a chain of coilable reclosable bags can be produced therefrom since the fasteners (26) are connected to the web preferably transversely to the bags longitudinal formation axis.

Abstract: A package having a reclosable pour spout is disclosed, with the package including front and rear package panels which may be joined at respective side edges thereof by inwardly extending side gussets. An upper edge portion of the package is removable, including one of the side gussets, to form a pour spout for dispensing the contents of the package. A fastener strip, which can be detachably connected to itself, extends between confronting inside surfaces of the front and rear package panels, adjacent to the pour spout, whereby the pour spout can be conveniently closed after the package is initially opened. A method of forming the present package is also disclosed.

Abstract: Reclosable bags, plastic film for making the bags, and a method and apparatus for making the bags are disclosed. The bag has a reclosable fastener (26) connected to a single wall of the bag, and the film (55) has a reclosable fastener (26) connected to one side thereofwhich does not require attachment to any other portion of the film (55) when making a bag. The fastener (26) has a tamper-proof member attached thereto to indicate if the bag has been previously opened. The film (55) can be wound into a roll (54) suitable for use on conventional bag making machines including form, fill, and seal machines or a chain of coilable reclosable bags can be produced therefrom since the fasteners (26) are connected tothe web preferably transversely to the bags longitudinal formation axis.

Abstract: A composition and method for treatment or prevention of human sexual dysfunction are disclosed. The method contemplates the topical application to a genital organ of composition containing an effective sexual arousal-inducing amount of a peroxide compound. Preferred peroxide compounds include benzoyl peroxide and carbamide peroxide, and mixtures thereof.

Abstract: The present invention contemplates a topical pharmaceutical composition that comprises a medium containing an anti-viral-effective amount of the dietary indole or derivative thereof admixed with a dietary indole compound-complexing amount of a hydroxypropyl-?-cyclodextrin dissolved or dispersed therein. Another embodiment utilizes sorbitol to stabilize the indole. The indole compound remains stable to degradation longer in the presence of the cyclodextrin compound that without it. The composition provides a stabilized aqueous indole composition that can be used to topically treat or prevent human papilloma virus (HPV) infection.

Abstract: A stabilized pharmaceutical composition that comprises a pharmaceutical compound that is labile to degradation in the presence of water is disclosed. That composition contains water, an effective amount of labile pharmaceutical compound and a degradation-inhibiting amount of a C4-C12 polyol that is substantially free of aldehyde or ketone carbonyl groups. The composition exhibits no more than 10 percent degradation of the labile pharmaceutical compound over a period of storage of at least 12 months when stored at ambient room temperature. A method of making the stabilized composition is also disclosed.

Abstract: A method for providing antimicrobial or antiviral preservation to a liquid-containing composition is disclosed. The method comprises dissolving or dispersing an antimicrobial or antiviral amount of a compound having a molecular weight of about 200 to about 800 Da that is (i) a hydrocarbyl aminohydrocarbonate, (ii) an aminohydrocarbyl hydrocarbonate, (iii) a mixture of (i) and (ii) in that liquid-containing composition. A method of sanitizing a surface is also contemplated that comprises applying a composition prepared by the above method to contact a surface to be sanitized and maintaining that contact for a time sufficient to sanitize the same.

Abstract: The invention provides compositions and methods suitable for ameliorating female sexual dysfunction, and in particular, female sexual arousal disorder. In preferred embodiments, the invention provides a semisolid composition suitable for topical application comprising: an effective amount of a vasoactive prostaglandin, a penetration enhancer, a polymer thickener, a lipophilic component, and an acidic buffer system. In other embodiments, the invention provides a method of treating female sexual arousal disorder by applying an effective dose of a topical semisolid prostaglandin composition to the anterior wall of the vagina.

Abstract: An aqueous pharmaceutical composition of a semi-solid consistency is provided for topical application of non-steroidal anti-inflammatory (NSAI) drugs. The composition comprises one or more NSAI drugs, a non-basic polymeric skin penetration enhancer and a lipophilic solvent. The polymeric skin penetration enhancer is present in an amount sufficient to enhance skin penetration of the NSAI drug. The lipophilic solvent is a mixture of an aliphatic C.sub.2 to C.sub.8 alcohol and an aliphatic C.sub.8 to C.sub.30 ester.

Abstract: A topical composition of a semi-solid consistency suitable is provided for transdermal application of prostaglandin E.sub.1. The composition comprises prostaglandin E.sub.1, a penetration enhancer, a polysaccharide gum, a lipophilic compound, and an acidic buffer system. The penetration enhancer is an alkyl-2-(N,N-disubstituted amino)-alkanoate ester, an (N,N-disubstituted amino)-alkanol alkanoate, or a mixture of these. The lipophilic compound may be an aliphatic C.sub.1 to C.sub.8 alcohol, an aliphatic C.sub.8 to C.sub.30 ester, or a mixture of these. The composition includes a buffer system capable of providing a buffered pH value for said composition in the range of about 3 to about 7.4.