Abstract: A biologic ventricular assist device that also has the capability to capture, grow, and administer stem cells to regenerate and restore damaged myocardium in the heart. The device works in conjunction with a traditional ventricular assist device and possesses an additional external path or tube that is in-line with the path of the ventricular assist device. The external path allows for the administration of stem cells, genes, genetically modified cells or other therapeutic biologic or pharmacologic agents, as well as leading to a stem cell collecting accessory that captures circulating stem cells. The stem cell collecting accessory is also associated with a chamber for culturing the captured stem cells.

Abstract: A biologic ventricular assist device that also has the capability to capture, grow, and administer stem cells to regenerate and restore damaged myocardium in the heart. The device works in conjunction with a traditional ventricular assist device and possesses an additional external path or tube that is in-line with the path of the ventricular assist device. The external path allows for the administration of stem cells, genes, genetically modified cells or other therapeutic biologic or pharmacologic agents, as well as leading to a stem cell collecting accessory (14) that captures circulating stem cells. The stem cell collecting accessory is also associated with a chamber (39) for culturing the captured stem cells.

Abstract: A biologic ventricular assist device that also has the capability to capture, grow, and administer stem cells to regenerate and restore damaged myocardium in the heart. The device works in conjunction with a traditional ventricular assist device and possesses an additional external path or tube that is in-line with the path of the ventricular assist device. The external path allows for the administration of stem cells, genes, genetically modified cells or other therapeutic biologic or pharmacologic agents, as well as leading to a stem cell collecting accessory (14) that captures circulating stem cells. The stem cell collecting accessory is also associated with a chamber (39) for culturing the captured stem cells.

Abstract: An expression vector for use in inhibiting cancerous cell growth includes the following: (a) a first promoter nucleotide sequence; (b) a first coding nucleotide sequence encoding for a receptor that interacts with an angiogenic growth factor operatively linked to the first promoter sequence; (c) a second promoter nucleotide sequence upstream or downstream from the first promoter nucleotide sequence; and (d) a second coding nucleotide sequence encoding for a cytokine operatively linked to the second promoter nucleotide sequence. The expression vector can be used in a method of inhibiting growth of cancerous cells by the following: (a) providing a dual expression vector; (b) introducing the expression vector into at least one cell capable of expressing at least one of the receptor or cytokine; and (c) producing the receptor and cytokine.