Abstract: Disclosed are compounds of Formula IIIb, their stereoisomers, tautomers, deuterates, pharmacologically acceptable salts, or hydrates thereof, methods of their preparation and pharmaceutical compositions and uses comprising such compounds. The Formula IIIb compounds are useful and highly effective as multi-targeted tyrosine kinase inhibitors in treating several kinds of cancers such as pancreatic cancer, lung cancer, renal cancer, liver cancer, gastric cancer, cervical cancer, leukemia, prostatic cancer, and other antitumor uses.

Abstract: Disclosed are a liquid hydrogenated nitrile-butadiene rubber, a preparation method therefor and the use thereof. In the liquid hydrogenated nitrile-butadiene rubber: the content of acrylonitrile is 15-50%; the hydrogenation saturation is 75-99.5%; the weight-average molecular weight (Mw) is 3,000-60,000; the molecular weight polydispersity index (PDI) is 2.0-8.0; and the glass transition temperature (Tg) is lower than ?28° C. The liquid hydrogenated nitrile-butadiene rubber is low in molecular weight and wide in molecular weight polydispersity, simultaneously has an excellent fluidity during processing and excellent mechanical properties after curing and has a unique application value in the field of special rubbers; and the preparation method therefor is simple and feasible in terms of the process.

Abstract: Disclosed are compounds of Formula IIIb, their stereoisomers, tautomers, deuterates, pharmacologically acceptable salts, or hydrates thereof, methods of their preparation and pharmaceutical compositions and uses comprising such compounds. The Formula IIIb compounds are useful and highly effective as multi-targeted tyrosine kinase inhibitors in treating several kinds of cancers such as pancreatic cancer, lung cancer, renal cancer, liver cancer, gastric cancer, cervical cancer, leukemia, prostatic cancer, and other antitumor uses.

Abstract: Disclosed are compounds of Formula III, their stereoisomers, tautomers, deuterates, pharmacologically acceptable salts, or hydrates thereof, methods of their preparation and pharmaceutical compositions comprising such compounds. The Formula III compounds are useful and highly effective as multi-targeted tyrosine kinase inhibitors in treating several kinds of cancers such as liver cancer, bladder cancer, thyroid cancer, cervical cancer, leukemia.

Abstract: The present invention relates to a polyurethane composite material, comprising a polyurethane resin matrix prepared from a polyurethane composition, and a reinforcement material, wherein the polyurethane composition comprises: A) an isocyanate component comprising one or more organic polyisocyanates; B) an isocyanate-reactive component comprising: b1) one or more organic polyols having an amount of 21-60 wt. % based on 100% by weight of the polyurethane composition; b2) one or more (meth)acrylates comprising hydroxyl groups; and C) a radical reaction initiator; wherein the polyurethane resin matrix is prepared under such reaction conditions that the polyurethane composition undergoes addition polymerization reaction of isocyanate groups and hydroxyl groups and radical polymerization reaction simultaneously. The present invention further relates to the preparation process of the polyurethane composite material.

Abstract: The present invention relates to a polyurethane composite material, comprising a polyurethane resin matrix prepared from a polyurethane composition, and a reinforcement material, wherein the polyurethane composition comprises: A) an isocyanate component comprising one or more organic polyisocyanates; B) an isocyanate-reactive component comprising: b1) one or more organic polyols having an amount of 21-60 wt. % based on 100% by weight of the polyurethane composition; b2) one or more (meth)acrylates comprising hydroxyl groups; and C) a radical reaction initiator; wherein the polyurethane resin matrix is prepared under such reaction conditions that the polyurethane composition undergoes addition polymerization reaction of isocyanate groups and hydroxyl groups and radical polymerization reaction simultaneously. The present invention further relates to the preparation process of the polyurethane composite material.

Abstract: The present invention relates to a polyurethane composite material, comprising a polyurethane resin matrix prepared from a polyurethane composition, and a reinforcement material, wherein the polyurethane composition comprises: A) an isocyanate component comprising one or more organic polyisocyanates; B) an isocyanate-reactive component comprising: b1) one or more organic polyols having an amount of 21-60 wt. % based on 100% by weight of the polyurethane composition; b2) one or more (meth)acrylates comprising hydroxyl groups; and C) a radical reaction initiator; wherein the polyurethane resin matrix is prepared under such reaction conditions that the polyurethane composition undergoes addition polymerization reaction of isocyanate groups and hydroxyl groups and radical polymerization reaction simultaneously. The present invention further relates to the preparation process of the polyurethane composite material.

Abstract: A load indicator for use with a fall protection apparatus having a line and a connector for connecting to a user includes a housing having a pass-through opening and a covered indicator region. At least a portion of the housing is configured for connecting to the line. The load indicator also includes a shear pin supported by the housing and extending across the pass-through opening, and a saddle extending across at least a portion of the pass-through opening and supported by at least a portion of the shear pin. The saddle is configured for connecting to at least a portion of the connector. The saddle is movable relative to the housing between a first position and a second position when a force exceeding a predetermined threshold value is applied on the saddle causing the shear pin to shear or break. At least a portion of the indicator region is uncovered in the second position of the saddle when the shear pin shears or breaks.

Abstract: The present invention relates to a process for preparing a polyurethane composite material, comprising steps of: I) preparing a premolded polyurethane molding body, wherein the premolded polyurethane molding body is prepared from a polyurethane composition under a condition that isocyanate groups and isocyanate-reactive groups comprised in the polyurethane composition undergo an addition reaction; II) curing the premolded polyurethane molding body to prepare the polyurethane composite material, wherein the premolded polyurethane molding body cures by the radical polymerization of active olefinic bonds. The process of the present application has a lower TVOC value and better processability.

Abstract: Provided are compounds antiviral compounds represented by formula Ia and Ib: that are highly potent as HCV NS5A inhibitors, where the structural variables are as defined herein. These compounds are useful in, for example, inhibiting Hepatitis C virus and treating Hepatitis C virus infections.

Abstract: A load indicator for use with a fall protection apparatus having a line and a connector for connecting to a user includes a housing having a pass-through opening and a covered indicator region. At least a portion of the housing is configured for connecting to the line. The load indicator also includes a shear pin supported by the housing and extending across the pass-through opening, and a saddle extending across at least a portion of the pass-through opening and supported by at least a portion of the shear pin. The saddle is configured for connecting to at least a portion of the connector. The saddle is movable relative to the housing between a first position and a second position when a force exceeding a predetermined threshold value is applied on the saddle causing the shear pin to shear or break. At least a portion of the indicator region is uncovered in the second position of the saddle when the shear pin shears or breaks.

Abstract: The present invention relates to a process for preparing a polyurethane composite material, comprising steps of: I) preparing a premolded polyurethane molding body, wherein the premolded polyurethane molding body is prepared from a polyurethane composition under a condition that isocyanate groups and isocyanate-reactive groups comprised in the polyurethane composition undergo an addition reaction; II) curing the premolded polyurethane molding body to prepare the polyurethane composite material, wherein the premolded polyurethane molding body cures by the radical polymerization of active olefinic bonds. The process of the present application has a lower TVOC value and better processability.

Abstract: The present invention relates to a polyurethane composite material, comprising a polyurethane resin matrix prepared from a polyurethane composition, and a reinforcement material, wherein the polyurethane composition comprises: A) an isocyanate component comprising one or more organic polyisocyanates; B) an isocyanate-reactive component comprising: b1) one or more organic polyols having an amount of 21-60 wt. % based on 100% by weight of the polyurethane composition; b2) one or more (meth)acrylates comprising hydroxyl groups; and C) a radical reaction initiator; wherein the polyurethane resin matrix is prepared under such reaction conditions that the polyurethane composition undergoes addition polymerization reaction of isocyanate groups and hydroxyl groups and radical polymerization reaction simultaneously. The present invention further relates to the preparation process of the polyurethane composite material.