Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for performing a machine learning task on a network input to generate a network output. In one aspect, one of the systems includes a neural network configured to perform the machine learning task, the neural network including one or more expert neural network blocks that each include router that performs expert-choice routing between multiple expert neural networks.

Abstract: A magnetoresistive magnetic field probe with rotating electromechanical modulator (1) comprises: a bulk cylindrical base (11), wherein the bulk cylindrical base (11) has a cavity structure, and a center axis of the bulk cylindrical base (11) overlaps with a z-axis of a cylindrical coordinate system; a first magnetic tile (12) and a second magnetic tile (13) attached to an outer side wall of the bulk cylindrical base (11); and a magnetoresistive sensor (14) and a reference signal generator (15) located on the center axis of the bulk cylindrical base (11). During operation, the bulk cylindrical base (11) rotates about the z-axis at a frequency f, and the first magnetic tile (12) and the second magnetic tile (13) modulate an external magnetic field into a sensed magnetic field having a frequency 2f, and a measurement signal having a frequency 2f is output via the magnetoresistive sensor (14). The reference signal generator (15) outputs a reference signal having a frequency 2f.

Abstract: Instead of having a constant boundary, artificial reality (XR) applications that can run in boundaryless mode (e.g., in augmented or mixed reality) can be given controls by selective boundary system on an XR system to customize partial boundaries. For example, an application can specify to select particular boundaries when certain object types are in the real-world environment. In another example, an application can transition to different boundary modes when certain application events occur (e.g., when transitioning from virtual reality to mixed reality). On the backend, the selective boundary system can provide the application with an API that exposes boundary information. Based on this information, the application can use the API to create new boundaries or turn on or off certain boundaries based on requests by the application.

Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

Abstract: Power connector systems that can have an asymmetric insertion-to-extraction force ratio such that they are easy to mate and can reliably remain connected during use. The power connector systems can have a low-profile for use in thin electronic devices.

Abstract: An integrated platform system that employ a series of machine learning techniques and prediction and detection units that can process input data and extract and generate meaningful insights and predictions therefrom. The system integrates together multiple different data storage types and applications that generates data of different types, and an associated processing system for processing the different data types, store the data in a common data model to normalize the data, determine the data lineage of the data, and then process the data using different types of techniques. The data can also be processed by a prediction unit for generating meaningful insights and predictions or by an anomaly detection unit for detecting one or more anomalies in the data.

Abstract: An aqueous solvent composition useful for CO2 capture is described, that includes one or more CO2-sorbing amines, e.g., an amino acid salt and a tertiary or a sterically hindered amine. The solvent composition may include one or more promoters that are effective to enhance solvent characteristics such as (i) CO2 sorption capacity, (ii) CO2 sorption rate, (iii) CO2 desorption capacity, (iv) CO2 desorption rate, and (v) regeneration temperature, in relation to a corresponding solvent lacking the promoters. In relation to existing CO2 capture solvent compositions, the disclosed aqueous solvent composition provides high solvent CO2 capacity, high rate of CO2 absorption and desorption, high thermal and oxidative stability, low solvent regeneration energy, low solvent emissions, and low solvent toxicity.

Abstract: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.

Abstract: The present application provides medical uses of biophoton generators, which can generate bioenergy for promoting health and wellness. In particular, present application provides methods of needleless biophoton therapies for optimizing meridian energy, either alone or in combination with the use of another therapeutic energy source, by using biophoton generators.

Abstract: A type of rotating disk magnetic field probe (1) comprising: a non-magnetic rotating disk (2), 4N first soft ferromagnetic sectors (3), M second soft ferromagnetic sectors (4), a reference signal generator, an X-axis magnetoresistive sensor (7, 8), a Y-axis magnetoresistive sensor (5,6), and a Z-axis magnetoresistive sensor (9). Both the first soft ferromagnetic sectors (3) and the second soft ferromagnetic sector (4) are located on the non-magnetic rotating disk (2). In operation, the non-magnetic rotating disk (2) rotates about a Z-axis at a frequency f. An external magnetic field is modulated by the first soft ferromagnetic sector (3) into an X-axis magnetic field sensed component and a Y-axis magnetic field sensed component having a frequency of 4N×f, and is modulated by the second soft ferromagnetic field sectors into a Z-axis magnetic field sensed component having a frequency of M×f.

Abstract: An analysis apparatus analyses a video image signal comprising successive frames of imaging an endoscopy procedure. A machine learning block analyses the video image signal using a machine learning technique that classifies regions of the frames as belonging to one of plural classes corresponding to respective types of image artefact. The classes include a motion blur class corresponding to motion blur of the image, at least one erroneous exposure class corresponding to a type of erroneous exposure of the image, and at least one noise artefact class corresponding to a type of image artefact that is noise. A quality score block derives quality scores representing image quality of the successive frames based on the classified regions.

Abstract: A glass manufacturing apparatus including a forming apparatus, the forming apparatus including an edge separation assembly. The edge separation assembly includes a scoring device with a scoring tool coupled thereto, a backing roller, a pair of stabilizing rollers configured to pinch a central portion of the glass ribbon therebetween, and a separation roller configured to apply a separation force against an edge portion of the glass ribbon to separate the edge portion from the central portion. The edge separation apparatus may further include a first plurality of guide rollers arranged to direct the separated edge portion away from the central portion and a second plurality of guide rollers configured to guide the central portion. The forming apparatus further includes a cross-cut assembly configured to separate a glass sheet from the central portion.

Abstract: Described herein are compounds, and methods for the treatment of coronavirus infection.

Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypetpide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

Abstract: Road vehicle comprising a passenger compartment configured to accommodate a driver and at least one passenger alongside the driver; a vehicle dashboard; a steering wheel; a content display device comprises: a support element hinged in the area of a central portion of the vehicle dashboard, at the front between a driver's seat and a passenger's seat; at least one screen mechanically connected to the support element and configured to be visible to a passenger and/or to a driver while driving; a time measurement system, in particular a chronograph; the vehicle comprises mechanical controls arranged, namely mounted, in the area of the steering to give instructions to the time measurement system.

Abstract: The present disclosure provides for a compound according to formula (I) or a pharmaceutically acceptable salt thereof as Cav1.2 activators for the treatment of schizophrenia, bipolar disorder, major depressive disorder, substance use disorder. ADHD, Phelan-Mc-Dermid Syndrome, autism spectrum disorder, multiple sclerosis, frontotemporal dementia, Alzheimer's disease. Brugada Syndrome. Short QT syndrome, or early repolarization syndrome.

Abstract: Described herein is N-[4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-4-[[3(R)-[(1-oxo-2-propen-1-yl)amino]-1-piperidinyl]methyl]-2-pyridinecarboxamide (Compound A) (Formula I), including crystalline forms, solvates, and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions or pharmaceutical formulations that include the compound, as well as methods of using the compound, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, diabetes, and inflammatory diseases or conditions.

Abstract: A structured adsorbent assembly is described, which is usefully employed for pressure swing adsorption (PSA) processing of ambient air to generate high purity oxygen. The structured adsorbent assembly in various implementations may include cellulosic carbon molecular sieve fibers formed by spinning of precursor cellulose followed by pyrolysis of the spun fibers, as an argon-selective adsorbent, or AgX zeolite contained on and/or in polymeric fibers, as an argon-selective adsorbent, and such argon-selective adsorbents may be in combination with nitrogen-selective adsorbent such as LiX zeolite contained on and/or in polymeric fibers. The structured adsorbent assembly may be employed in PSA systems and processes to achieve highly efficient and economic generation of high purity oxygen for applications such as distributed gasification power generation.

Abstract: A structured tissue belt assembly including a supporting layer, a non-woven web contacting layer, and one or more laser welds that attach the bottom surface of the web contacting layer to the top surface of the supporting layer. The structured tissue belt assembly allows for air flow in x, y and z directions. In exemplary embodiments, the structured tissue belt assembly has an embedment distance between the supporting layer and the web contacting layer of 0.05 mm to 0.60 mm and a peel force between the web contacting layer and the supporting layer of at least 650 gf/inch.

Abstract: Provided herein are compositions and methods for purifying and concentrating nucleic acids from large-volume samples. In particular, reagents are provided for non-specifically binding total nucleic acid to a solid surface, separating bound nucleic acid from a large-volume sample, separating nucleic acid from amplification inhibitors, and/or eluting nucleic acids into a small volume amenable to further analysis.