Abstract: Systems and methods for determining a placement for computational graph across multiple hardware devices. One of the methods includes generating a policy output using a policy neural network and using the policy output to generate a final placement that satisfies one or more constraints.

Abstract: A device may include a processor configured to determine a first position of a physical camera in a physical environment, transmit the first position to a second device, obtain metadata of the physical camera, and cause a modification of a virtual camera of the second device based on the metadata. The processor is also configured to obtain, from the second device, at least one virtual image frame captured by the virtual camera placed at a second position in a computer-generated environment, and to obtain, from the physical camera, at least one image frame captured from the physical environment. The processor is also configured to generate a composite image frame including at least a portion of at least one virtual image frame composited with at least a portion of the at least one image frame, and display the composite image frame.

Abstract: A stabilized flour, such as stabilized whole grain wheat flour, exhibiting unexpectedly superior extended shelf life and superior biscuit baking functionality, may be produced with or without heating to inhibit lipase by subjecting whole grains or a bran and germ fraction or component to treatment with a lipase inhibitor, such as an acid or green tea extract. Treatment with the lipase inhibitor may be performed during tempering of the whole grains or berries or during hydration of the bran and germ fraction or component.

Abstract: The present disclosure relates to a process for manufacturing an oral pharmaceutical dosage form including: mixing an active pharmaceutical ingredient (API) and surfactant into a blend; feeding the blend into a processor that applies heat and shear forces at a temperature within a range of approximately equal to the melting point of the surfactant to 3° C. below the melting point of the surfactant so as to form API granulates; and formulating the API granulates into a dosage form. The disclosed technology provides a surprisingly effective and economical means for producing high dose solid dosage forms containing poorly soluble APIs with minimal excipient burden.

Abstract: Systems and techniques are provided for optimizing the performance of a target for a downhole neutron generator. An example method can include disposing a first source material and a first substrate in a vacuum chamber at an initial temperature, evaporating the first source material to be deposited onto a surface of the first substrate, monitoring a temperature of the first substrate during the evaporation of the first source material, and determining a thermal equilibrium process temperature at which the temperature of the first substrate is stabilized. The example method can further include disposing a second source material and a second substrate in the vacuum chamber at the thermal equilibrium process temperature, evaporating the second source material to be deposited onto a surface of the second substrate, and obtaining the second substrate deposited with the second source material for a target of a downhole neutron generator.

Abstract: A structured tissue belt assembly including a supporting layer and a nonwoven web contacting layer. The supporting layer has a top surface and a bottom surface and is formed of monofilaments including one or more layers of warp yarns interwoven with weft yarns in a repeating pattern. At least one of: a) at least some of the warp yarns; or b) at least some of the weft yarns, include laser energy absorbent material, and at least one of: a) at least some of the warp yarns; or b) at least some of the weft yarns include laser energy scattering material. Laser welds attach the bottom surface of the web contacting layer to the top surface of the supporting layer at points where the web contacting layer contacts the at least one of: a) the at least some of the warp yarns; or b) the at least some of the weft yarns that include laser energy absorbent material.

Abstract: The disclosure provides antibodies that specifically bind to a cleaved CDCP1 and antigen binding fragments thereof and methods of use thereof. In some aspects, the disclosure is directed to methods of treating a cancer in a subject, comprising administering to the subject an antibody or antigen-binding fragment thereof that specifically binds to a cleaved human CDCP1.

Abstract: An anti-angiogenic composition is disclosed. The anti-angiogenic composition includes a multi-tyrosine kinase inhibitor having a chemical structure: where the tyrosine kinase inhibitor has a crystalline structure having a single crystal polymorph. The anti-angiogenic composition including the tyrosine kinase inhibitor, as characterized by powder x-ray diffraction, has diffraction peaks at 2? of 11.37 150 18.04 242 288 and 24.72. The tyrosine kinase inhibitor may have a particle size of from about 50 to about 300 microns. The tyrosine kinase inhibitor is injectable. The tyrosine kinase inhibitor has an anti-angiogenic efficacy as indicated by a reduction in endothelial cell marker cd31, vascular endothelial-cadherin (VE-CDH), smooth muscle pericyte marker alpha smooth muscle actin (ASMACT), or a combination thereof, as compared to a control composition.

Abstract: Described herein are methods of purifying nucleic acids (e.g., mRNAs) from feed solutions using continuous, multicolumn chromatography approaches. Also described are methods of increasing the efficiency of chromatography methods by performing purification methods in parallel using multiple columns.

Abstract: A data processor includes a plurality of requestors, a plurality of responders, and a data fabric. The data fabric is for routing requests between the plurality of requestors and the plurality of responders and has a plurality of non-operational power states including a normal C-state and a light-weight C-state. The light-weight C-state has lower entry and exit latencies than the normal C-state. The data fabric monitors traffic through the data fabric and places the data fabric in the light-weight C-state in response to detecting an idle traffic state.

Abstract: A bioenergy generator to increase the life force of a biological system is provided. The bioenergy generator includes fine pieces of natural stone selected from the group of diamond, amethyst, tourmaline, jadestone with any color, and obsidian. The bioenergy generator includes fine pieces of natural sand selected from the group of white sand, black sand, pink sand, red sand, yellow sand, orange sand, and green sand. The bioenergy generator includes fine pieces of metal selected from the group of steel, iron, copper, zinc, aluminum, calcium, magnesium, silver, and gold. The bioenergy generator includes water and a supporting material operable to hold the natural sand, the natural stone, the metal, and the water together. Uses of the bioenergy generator are also provided, in particular, to enhance natural healing ability of a biological body and to treat a disease in a mammal.

Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

Abstract: Systems, apparatus, articles of manufacture, and methods are disclosed to determine confidence of motion vectors. Examples disclosed herein are to generate feature data associated with a motion vector, the motion vector generated based on a first block of pixel data in a first video frame and a second block of pixel data in a second video frame, determine a confidence score for the motion vector based on a model and the feature data, and concatenate the motion vector and the confidence score to output an estimated likelihood that the motion vector is accurate.

Abstract: A component carrier and a method of manufacturing the component carrier are presented. The component carrier includes a stack with a plurality of electrically insulating layer structures and one or more electrically conductive layer structures, the one or more electrically conductive layer structures include two opposed conductive surfaces; a plurality of first vias, formed at a front side of the stack, the plurality of first vias are connected to one of the two opposed conductive surfaces through a respective first baseline-etch surface; and a plurality of second vias, formed at a back side of the stack, the front side is opposed to the back side, wherein the plurality of second vias is connected to the other one of the two opposed conductive surfaces through a respective second baseline-etch surface.

Abstract: A spectrometer for detecting an electromagnetic (EM) wave spectrum having one or more wavelength components within a spectral band of interest, and a method of detecting an electromagnetic (EM) wave spectrum having one or more wavelength components within a spectral band of interest.

Abstract: Provided herein are assays utilizing oxygen-sensitive fluorescent materials for the detection of oxygen. In particular, oxygen-sensitive fluorescent particles are provided for monitoring the oxygen consumption rate and metabolic fitness of living cells.

Abstract: Described herein is N-[4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-4-[[3(R)-[(1-oxo-2-propen-1-yl)amino]-1-piperidinyl]methyl]-2-pyridinecarboxamide (Compound A) (Formula I), including crystalline forms, solvates, and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions or pharmaceutical formulations that include the compound, as well as methods of using the compound, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, diabetes, and inflammatory diseases or conditions.

Abstract: A stabilized flour, such as stabilized whole grain wheat flour, exhibiting unexpectedly superior extended shelf life and superior biscuit baking functionality, may be produced with or without heating to inhibit lipase by subjecting whole grains or a bran and germ fraction or component to treatment with a lipase inhibitor, such as an acid or green tea extract. Treatment with the lipase inhibitor may be performed during tempering of the whole grains or berries or during hydration of the bran and germ fraction or component.

Abstract: A construction method for and an application of a nucleic acid multimerization-mediated multivalent protein drug and vaccine. Specifically provided is a multimeric complex based on complementary nucleic acid backbones. The complex is a multimer formed by complexing of 3-6 monomers having complementary nucleic acid backbones, wherein each monomer is a polypeptide having a nucleic acid single strand. In the multimer, the nucleic acid single strand of each monomer and the nucleic acid single strands of the other two monomers form double strands by means of base complementation, so as to form complementary nucleic acid backbone structures. Also provided are a pharmaceutical composition containing the multimeric complex, a nucleic acid sequence library used for constructing the multimeric complex, and a method for optimizing complementary nucleic acid backbones.

Abstract: Disclosed herein are medical devices, uses thereof, methods of manufacture, and kits comprising medical devices. Also disclosed herein are uses of medical devices. For example, medical devices are used to produced biophotons for biophoton therapy. Also disclosed herein is the administration of biophoton therapy for the treatment of stroke in a subject in need thereof.