Patents by Inventor Jamey Marth

Jamey Marth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Regulation of glucose and insulin levels by GnT-4 glycosyltransferase activity
    Patent number: 8034556
    Abstract: The invention is based on the discovery that the gylcosylation enzyme GnT-4 increases glyocsylation and the stability of glucose transporter (Glut) family members, e.g., by increasing lectin binding. Modulators of GnT-4 activity can therefore be identified and used for the treatment of diabetes or pre-diabetes. In addition, inhibitors of GnT-4 activity can be used for the treatment of cancer.
    Type: Grant
    Filed: May 27, 2005
    Date of Patent: October 11, 2011
    Assignee: The Regents of the University of California
    Inventors: Jamey Marth, Kazuaki Ohtsubo
  • Dampening Humoral and Innate Immunity by Inhibition of Ppgalnact-1
    Publication number: 20080227689
    Abstract: The invention provides methods and compositions for treating pathogenic immune and inflammatory disorders through inhibition of polypeptide GalNAc transferase 1 (ppGalNAcT-1) transferase activity.
    Type: Application
    Filed: September 29, 2006
    Publication date: September 18, 2008
    Inventors: Jamey Marth, Mari Tenno
  • USE OF CORE 2 GlcNAc TRANSFERASE INHIBITORS IN TREATING INFLAMMATION
    Publication number: 20080031821
    Abstract: This invention provides compounds and methods for treating inflammation. The compounds modulate the core 2 oligosaccharide-mediated binding of inflammatory cells, such as neutrophils, to endothelial cells and other myeloid cells. Significantly, the of the invention methods block inflammation without affecting lymphocyte trafficking. In some embodiments, the compounds inhibit the activity of a core 2 GlcNAc transferase that is involved in synthesizing the core 2 oligosaccharides.
    Type: Application
    Filed: July 17, 2007
    Publication date: February 7, 2008
    Applicant: The Regents of the University of California
    Inventors: Jamey Marth, Lesley Ellies
  • REGULATION OF GLUCOSE AND INSULIN LEVELS BY GNT-4 GLYCOSYLTRANSFERASE ACTIVITY
    Publication number: 20070259379
    Abstract: The invention is based on the discovery that the gylcosylation enzyme GnT-4 increases glyocsylation and the stability of glucose transporter (Glut) family members, e.g., by increasing lectin binding. Modulators of GnT-4 activity can therefore be identified and used for the treatment of diabetes or pre-diabetes. In addition, inhibitors of GnT-4 activity can be used for the treatment of cancer.
    Type: Application
    Filed: May 27, 2005
    Publication date: November 8, 2007
    Inventor: Jamey Marth
  • Anxiolytic treatment by inhibition of a polysialyltransferase
    Publication number: 20070142319
    Abstract: The invention provides methods and compositions for treating anxiety and fear disorders through inhibition of ?-2,8-sialyltransferase activity.
    Type: Application
    Filed: February 17, 2005
    Publication date: June 21, 2007
    Applicants: The Burnham Institute, The Regenta of the University of California Office of Technology Transfer
    Inventors: Jamey Marth, Minoru Fukuda
  • DIAGNOSIS OF HUMAN GLYCOSYLATION DISORDERS
    Publication number: 20060228762
    Abstract: This invention provides methods and kits for use in diagnosing genetically transmitted diseases that are associated with deficiencies in glycosylation of glycoconjugates such as glycoproteins, glycolipids, and proteoglycans. The methods and kits are also useful for monitoring the course of treatment of diseases that are associated with glycosylation disorders.
    Type: Application
    Filed: May 5, 2006
    Publication date: October 12, 2006
    Applicants: The Regents of the University of California, The Burnhan Institute
    Inventors: Jamey Marth, Hudson Freeze