Abstract: Systems and methods of the present disclosure include processing devices to receive patient vital measurement data, including time-sequences of respiration rate measurements, heart rate measurements, blood pressure measurements, and temperature measurements, during a preceding time period preceding a prediction period. The processing devices utilize a risk prediction model to predict a probability of a low risk classification for the prediction period based on the vital measurements of the preceding time period. The processing devices produce a risk classification for the prediction period based on a probability of the low risk classification exceeding a classification probability threshold, where the risk classification includes one of a low-risk classification and a not-low-risk classification.