Patents by Inventor Jamie MARSHALL

Jamie MARSHALL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline forms of plasma kallikrein inhibitors
    Patent number: 12240818
    Abstract: Pure crystalline forms of 1-benzyl-N-(4-carbamimidoylbenzyl)-1H-pyrazole-4-carboxamide acetate, and an amorphous form, pharmaceutical compositions thereof, and methods for making the same, are disclosed.
    Type: Grant
    Filed: March 14, 2022
    Date of Patent: March 4, 2025
    Assignees: Rezolute, Inc., ActiveSite Pharmaceuticals, Inc.
    Inventors: Sukanto Sinha, Tamie Chilcote, Julian Scott Northen, Jamie Marshall
  • MULTIMODAL READOUTS FOR QUANTIFYING AND SEQUENCING NUCLEIC ACIDS IN SINGLE CELLS
    Publication number: 20230092323
    Abstract: Provided herein are methods for generating single-cell molecular analysis comprising a) delivering one or more proximity dependent probes to a cell population, wherein each proximity dependent probe comprises a target binding region configured to bind a target RNA and a primer binding site region; b) linking bound proximity dependent probes; c) isolating single cells from the cell population in separate individual discrete volumes, the individual discrete volumes further comprising a primer pair and amplification reagents, wherein the primer pair binds to the primer binding sites of the ligation dependent probes, and wherein at least one primer comprises a barcode sequence that uniquely identifies the individual discrete volume; d) amplifying the ligated probes using the primer pair, wherein the barcode is incorporated into each resulting amplicon; and e) quantifying target RNAs in each individual cell based at least in part on sequencing the resulting amplicons.
    Type: Application
    Filed: August 15, 2022
    Publication date: March 23, 2023
    Inventors: Fei CHEN, Jesse ENGREITZ, Jamie MARSHALL, Vidya SUBRAMANIAN, Sam RODRIQUES
  • POLYMORPHS OF TRIAZOLE ANTIFUNGAL COMPOUND PC945
    Publication number: 20230028714
    Abstract: The invention relates to crystalline polymorphic manifestations of a compound of formula (I) and related aspects.
    Type: Application
    Filed: December 4, 2020
    Publication date: January 26, 2023
    Applicant: Pulmocide Limited
    Inventors: Christopher John WALLIS, Gerald STEELE, Suzanne BUTTAR, Osama SULEIMAN, Julian NORTHEN, John MYKYTIUK, Jamie MARSHALL
  • CRYSTALLINE FORMS OF PLASMA KALLIKREIN INHIBITORS
    Publication number: 20220380315
    Abstract: Pure crystalline forms of 1-benzyl-N-(4-carbamimidoylbenzyl)-1H-pyrazole-4-carboxamide acetate, and an amorphous form, pharmaceutical compositions thereof, and methods for making the same, are disclosed.
    Type: Application
    Filed: March 14, 2022
    Publication date: December 1, 2022
    Inventors: Sukanto SINHA, Tamie CHILCOTE, Julian Scott NORTHEN, Jamie MARSHALL
  • Multimodal readouts for quantifying and sequencing nucleic acids in single cells
    Patent number: 11414701
    Abstract: Provided herein are methods for generating single-cell molecular analysis comprising a) delivering one or more proximity dependent probes to a cell population, wherein each proximity dependent probe comprises a target binding region configured to bind a target RNA and a primer binding site region; b) linking bound proximity dependent probes; c) isolating single cells from the cell population in separate individual discrete volumes, the individual discrete volumes further comprising a primer pair and amplification reagents, wherein the primer pair binds to the primer binding sites of the ligation dependent probes, and wherein at least one primer comprises a barcode sequence that uniquely identifies the individual discrete volume; d) amplifying the ligated probes using the primer pair, wherein the barcode is incorporated into each resulting amplicon; and e) quantifying target RNAs in each individual cell based at least in part on sequencing the resulting amplicons.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: August 16, 2022
    Assignees: THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Fei Chen, Jesse Engreitz, Jamie Marshall, Vidya Subramanian, Sam Rodriques
  • Crystalline forms of plasma kallikrein inhibitors
    Patent number: 11306061
    Abstract: Pure crystalline forms of 1-benzyl-N-(4-carbamimidoylbenzyl)-1H-pyrazole-4-carboxamide acetate, and an amorphous form, pharmaceutical compositions thereof, and methods for making the same, are disclosed.
    Type: Grant
    Filed: July 7, 2020
    Date of Patent: April 19, 2022
    Assignees: Rezolute, Inc., ActiveSite Pharmaceuticals, Inc.
    Inventors: Sukanto Sinha, Tamie Chilcote, Julian Scott Northen, Jamie Marshall
  • CRYSTALLINE FORMS OF PLASMA KALLIKREIN INHIBITORS
    Publication number: 20210009525
    Abstract: Pure crystalline forms of 1-benzyl-N-(4-carbamimidoylbenzyl)-1H-pyrazole-4-carboxamide acetate, and an amorphous form, pharmaceutical compositions thereof, and methods for making the same, are disclosed.
    Type: Application
    Filed: July 7, 2020
    Publication date: January 14, 2021
    Inventors: Sukanto SINHA, Tamie CHILCOTE, Juilian Scott NORTHEN, Jamie MARSHALL
  • MULTIMODAL READOUTS FOR QUANTIFYING AND SEQUENCING NUCLEIC ACIDS IN SINGLE CELLS
    Publication number: 20190360044
    Abstract: Provided herein are methods for generating single-cell molecular analysis comprising a) delivering one or more proximity dependent probes to a cell population, wherein each proximity dependent probe comprises a target binding region configured to bind a target RNA and a primer binding site region; b) linking bound proximity dependent probes; c) isolating single cells from the cell population in separate individual discrete volumes, the individual discrete volumes further comprising a primer pair and amplification reagents, wherein the primer pair binds to the primer binding sites of the ligation dependent probes, and wherein at least one primer comprises a barcode sequence that uniquely identifies the individual discrete volume; d) amplifying the ligated probes using the primer pair, wherein the barcode is incorporated into each resulting amplicon; and e) quantifying target RNAs in each individual cell based at least in part on sequencing the resulting amplicons.
    Type: Application
    Filed: May 24, 2019
    Publication date: November 28, 2019
    Inventors: Fei CHEN, Jesse ENGREITZ, Jamie MARSHALL, Vidya SUBRAMANIAN, Sam Rodriques