Abstract: A facilitated rupturable multilayer seal comprising a deformation layer and a layer free of deformation, or an upper portion and a lower portion, where the upper portion comprises a deformation layer and the lower portion comprises a layer free of deformation, where the deformation layer may be comprised of multiple layers; where the layer free of deformation may be comprised of multiple layers. The deformation layer and the layer free of deformation are combined and fixed to each other, and form a moisture and vapor resistant barrier. The multilayer seal allows for both containment of liquids, as well as separation of solids and liquids, with a solid impervious barrier and yet it is easily broken, allowing either access to, or transfer of, a solid or liquid out of or into a container, including the mixing of a solid with a liquid or a liquid with a liquid.