Patents by Inventor Jamie Rossjohn
Jamie Rossjohn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 10245262Abstract: The present invention provides ligands which bind to MR1, some of which induce MR1 to bind to MAIT cells thereby activating or inhibiting MAIT cell activation.Type: GrantFiled: April 1, 2015Date of Patent: April 2, 2019Assignees: The University of Queensland, Monash University, The University of MelbourneInventors: Alexandra Jane Corbett, James McCluskey, Lars Kjer-Nielsen, Zhenjun Chen, Jamie Rossjohn, Onisha Patel, Richard William Birkinshaw, Sidonia Barbara Guiomar Eckle, David Paul Fairlie, Ligong Liu, Jeffrey Yam Wing Mak
-
Patent number: 10011602Abstract: The present invention provides a ligand which binds to MR1 wherein said binding results in binding of the MR1 to MAIT cells.Type: GrantFiled: July 5, 2013Date of Patent: July 3, 2018Assignee: THE UNIVERSITY OF MELBOURNEInventors: Lars Kjer-Nielsen, James McCluskey, Alexandra Corbett, Jamie Rossjohn, Patel Onisha, David Paul Fairlie, Ligong Liu
-
Publication number: 20170209442Abstract: The present invention provides ligands which bind to MR1, some of which induce MR1 to bind to MAIT cells thereby activating or inhibiting MAIT cell activation.Type: ApplicationFiled: April 1, 2015Publication date: July 27, 2017Inventors: Alexandra Jane Corbett, James McCluskey, Lars Kjer-Nielsen, Zhenjun Chen, Jamie Rossjohn, Onisha Patel, Richard William Birkinshaw, Sidonia Barbara Guiomar Eckle, David Paul Fairlie, Ligong Liu, Jeffrey Yam Wing Mak
-
Publication number: 20150166542Abstract: The present invention provides a ligand which binds to MR1 wherein said binding results in binding of the MR1 to MAIT cells.Type: ApplicationFiled: July 5, 2013Publication date: June 18, 2015Applicant: THE UNIVERSITY OF MELBOURNEInventors: Lars Kjer-Nielsen, James McCluskey, Alexandra Corbett, Jamie Rossjohn, Patel Onisha, David Paul Fairlie, Ligong Liu
-
Patent number: 7593820Abstract: The present invention relates to X-ray crystallography studies of a human Janus Kinase 2 (JAK2) domain. More particularly, it relates to the crystal structure of a JAK2 kinase domain bound to a inhibitor. The invention further relates to the use of the crystal and related structural information to select and screen for compounds that interact with JAK2 and related proteins and to compounds that could be used for the treatment of diseases mediated by inappropriate JAK2 activity.Type: GrantFiled: October 11, 2005Date of Patent: September 22, 2009Assignee: Cytopia Research Pty LtdInventors: Andrew Frederick Wilks, Christopher John Burns, Emmanuelle Fantino, Isabelle Lucet, Jamie Rossjohn, Michelle Leanne Styles
-
Publication number: 20070276607Abstract: The present invention relates to X-ray crystallography studies of a JAK2 kinase domain. More particularly, it relates to the crystal structure of a JAK2 kinase domain bound to an inhibitor. The invention further relates to the use of the crystal and related structural information to select and screen for compounds that interact with JAK2 and related proteins and to compounds that could be used for the treatment of diseases mediated by inappropriate JAK2 activity.Type: ApplicationFiled: January 4, 2007Publication date: November 29, 2007Inventors: Andrew Wilks, Christopher Burns, Emmanuelle Fantino, Isabelle Lucet, Jamie Rossjohn, Michelle Styles
-
Publication number: 20070136006Abstract: The present invention relates to X-ray crystallography studies of a JAK2 kinase domain. More particularly, it relates to the crystal structure of a JAK2 kinase domain bound to an inhibitor. The invention further relates to the use of the crystal and related structural information to select and screen for compounds that interact with JAK2 and related proteins and to compounds that could be used for the treatment of diseases mediated by inappropriate JAK2 activity.Type: ApplicationFiled: January 4, 2007Publication date: June 14, 2007Inventors: Andrew Wilks, Christopher Burns, Emmanuelle Fantino, Isabelle Lucet, Jamie Rossjohn, Michelle Styles
-
Publication number: 20070136005Abstract: The present invention relates to X-ray crystallography studies of a JAK2 kinase domain. More particularly, it relates to the crystal structure of a JAK2 kinase domain bound to an inhibitor. The invention further relates to the use of the crystal and related structural information to select and screen for compounds that interact with JAK2 and related proteins and to compounds that could be used for the treatment of diseases mediated by inappropriate JAK2 activity.Type: ApplicationFiled: January 4, 2007Publication date: June 14, 2007Inventors: Andrew Wilks, Christopher Burns, Emmanuelle Fantino, Isabelle Lucet, Jamie Rossjohn, Michelle Styles
-
Publication number: 20070129896Abstract: The present invention relates to X-ray crystallography studies of a JAK2 kinase domain. More particularly, it relates to the crystal structure of a JAK2 kinase domain bound to an inhibitor. The invention further relates to the use of the crystal and related structural information to select and screen for compounds that interact with JAK2 and related proteins and to compounds that could be used for the treatment of diseases mediated by inappropriate JAK2 activity.Type: ApplicationFiled: January 4, 2007Publication date: June 7, 2007Inventors: Andrew Wilks, Christopher Burns, Emmanuelle Fantino, Isabelle Lucet, Jamie Rossjohn, Michelle Styles
-
Publication number: 20070128709Abstract: The present invention relates to X-ray crystallography studies of a human Janus Kinase 2 (JAK2) domain. More particularly, it relates to the crystal structure of a JAK2 kinase domain bound to an inhibitor. The invention further relates to the use of the crystal and related structural information to select and screen for compounds that interact with JAK2 and related proteins and to compounds that could be used for the treatment of diseases mediated by inappropriate JAK2 activity.Type: ApplicationFiled: October 11, 2005Publication date: June 7, 2007Inventors: Andrew Wilks, Christopher Burns, Emmanuelle Fantino, Isabelle Lucet, Jamie Rossjohn, Michelle Styles
-
Publication number: 20070129895Abstract: The present invention relates to X-ray crystallography studies of a JAK2 kinase domain. More particularly, it relates to the crystal structure of a JAK2 kinase domain bound to an inhibitor. The invention further relates to the use of the crystal and related structural information to select and screen for compounds that interact with JAK2 and related proteins and to compounds that could be used for the treatment of diseases mediated by inappropriate JAK2 activity.Type: ApplicationFiled: January 4, 2007Publication date: June 7, 2007Inventors: Andrew Wilks, Christopher Burns, Emmanuelle Fantino, Isabelle Lucet, Jamie Rossjohn, Michelle Styles
-
Patent number: 7220829Abstract: The present invention provides a cytokine-binding domain or portion thereof which binds to at least one cytokine and is capable of transducing a cytokine signal through a single cytokine receptor, said domain comprising a portion of the B?-C? loop of domain 4 of a ?c chain or analogous structure of a cytokine receptor. In another aspect of the invention there is provided a method of identifying a compound having cytokine agonist or antagonist activity, said method including subjecting a potential cytokine agonist and/or cytokine antagonist compound to a cytokine binding domain or portion thereof wherein said domain binds to at least one cytokine and is capable of transducing a cytokine signal through a single cytokine receptor, said domain comprising a portion of the B?-C? loop of domain 4 of a ?c chain or analogous structure of the cytokine receptor; and determining the presence of an agonist or antagonist response of the compound on the activity of a cytokine.Type: GrantFiled: August 8, 2001Date of Patent: May 22, 2007Assignee: Medvet Science Pty. Ltd.Inventors: Jamie Rossjohn, William John McKinstry, Joanna May Woodcock, Michael William Parker, Angel Francisco Lopez, Christopher James Bagley
-
Publication number: 20060122107Abstract: The present invention relates generally to a method of modulating T cell functional activity by utilising ?-amino acid substituted peptides and to agents useful for the same. More particularly, the present invention relates to a method of modulating class I restricted T cell activity by utilising ?-amino acid substituted peptides and to agents useful for the same. The method of the present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by suboptimal T cell stimulation such as that which occurs in some viral infections and in anti-tumour immunity, as well as aberrant, unwanted or otherwise inappropriate T cell functioning such as, but not limited to, graft rejection or autoimmune conditions, the present invention is further directed to methods of identifying, designing and/or modifying agents capable of modulating T cell functional activity.Type: ApplicationFiled: September 4, 2003Publication date: June 8, 2006Applicants: Monash University, The University of MelbourneInventors: Marie-Isabel Aguilar, Patrick Perlmutter, Anthony Purcell, Andrew Webb, Jamie Rossjohn
-
Publication number: 20030044975Abstract: The present invention provides a cytokine-binding domain or portion thereof which binds to at least one cytokine and is capable of transducing a cytokine signal through a single cytokine receptor, said domain comprising a portion of the B′-C′ loop of domain 4 of a &bgr;c chain or analogous structure of a cytokine receptor. In another aspect of the invention there is provided a method of identifying a compound having cytokine agonist or antagonist activity, said method including subjecting a potential cytokine agonist and/or cytokine antagonist compound to a cytokine binding domain or portion thereof wherein said domain binds to at least one cytokine and is capable of transducing a cytokine signal through a single cytokine receptor, said domain comprising a portion of the B′-C′ loop of domain 4 of a &bgr;c chain or analogous structure of the cytokine receptor; and determining the presence of an agonist or antagonist response of the compound on the activity of a cytokine.Type: ApplicationFiled: August 8, 2001Publication date: March 6, 2003Inventors: Jamie Rossjohn, William John McKinstry, Joanna May Woodcock, Michael William Parker, Angel Francisco Lopez, Christopher James Bagley