Patents by Inventor Jamil Rehman

Jamil Rehman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gene therapy for regulating smooth muscle tone
    Publication number: 20070086982
    Abstract: The present invention is directed towards a method of regulating smooth muscle tone, comprising the introduction, into smooth muscle cells of a subject, of a DNA sequence encoding a protein involved in the regulation of smooth muscle tone, and expression of the DNA sequence in a sufficient number of smooth muscle cells of the subject to regulate smooth muscle tone in the subject. Specifically, the invention provides methods of gene therapy for treating erectile dysfunction, bladder dysfunction, and other smooth muscle disorders. The present invention also provides recombinant viral and non-viral vectors comprising DNA encoding a protein involved in the regulation of smooth muscle tone. Further provided by the present invention is a smooth muscle cell which expresses a gene encoding a protein involved in the regulation of smooth muscle tone.
    Type: Application
    Filed: December 1, 2005
    Publication date: April 19, 2007
    Inventors: Jan Geliebter, George Christ, Arnold Melman, Jamil Rehman
  • Method of enhancing relaxation of penile smooth muscle by introduction of DNA encoding maxi-K potassium channel protein
    Patent number: 7030096
    Abstract: The present invention is directed towards a method of regulating smooth muscle tone, comprising the introduction, into smooth muscle cells of a subject, of a DNA sequence encoding a protein involved in the regulation of smooth muscle tone, and expression of the DNA sequence in a sufficient number of smooth muscle cells of the subject to regulate smooth muscle tone in the subject. Specifically, the invention provides methods of gene therapy for treating erectile dysfunction, bladder dysfunction, and other smooth muscle disorders. The present invention also provides recombinant viral and non-viral vectors comprising DNA encoding a protein involved in the regulation of smooth muscle tone. Further provided by the present invention is a smooth muscle cell which expresses a gene encoding a protein involved in the regulation of smooth muscle tone.
    Type: Grant
    Filed: March 21, 2000
    Date of Patent: April 18, 2006
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Jan Geliebter, George J. Christ, Arnold Melman, Jamil Rehman
  • Gene therapy for alleviating erectile dysfunction
    Patent number: 6150338
    Abstract: The present invention is directed towards gene therapy for erectile dysfunction through delivery and expression of a recombinant vector containing a DNA sequence encoding a protein involved in the regulation of smooth muscle tone into a smooth muscle cell. Also provided by the present invention is a method of inducing penile erection in a subject comprising the introduction and expression of a DNA sequence encoding a protein involved in the regulation of smooth muscle tone into a sufficient number of cells of the subject to induce penile erection in the subject. The present invention also provides a recombinant vector comprising the DNA of or corresponding to at least a portion of the genome of a virus, which portion is capable of directing the expression of a DNA sequence, and DNA encoding a protein involved in the regulation of smooth muscle tone operably linked to the viral DNA and capable of being expressed as a functional gene product in the target cell.
    Type: Grant
    Filed: February 13, 1997
    Date of Patent: November 21, 2000
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Jan Geliebter, Arnold Melman, George J. Christ, Jamil Rehman