Patents by Inventor Jamshed H. Shah
Jamshed H. Shah has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8158612Abstract: Compositions and methods for treating mammalian diseases or conditions characterized by undesirable angiogenesis by administering an effective amount of a compound of the formulae: wherein Ra is selected from —OCH3, —OCH2CH3 or —CCCH3; and Z is selected from >C(H)—OH, >C(H)—O-alkyl, >C(H)—O-sulfamate, where alkyl is a linear, branched and/or cyclic hydrocarbon chain comprising 1 to 10 carbons.Type: GrantFiled: December 22, 2008Date of Patent: April 17, 2012Assignee: EntreMed, Inc.Inventors: Gregory E. Agoston, Jamshed H. Shah, Lita Suwandi, Theresa M. LaVallee, Anthony M. Treston
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Patent number: 8153806Abstract: The invention provides new and useful analogs of 4-amino-thalidomide. These analogs include S(?)-4-amino-thalidomide and R(+)-4-amino-thalidomide. The invention also provides processes for making these analogs. Further, the invention provides methods for inhibiting angiogenesis and treating angiogenesis-associated diseases, including cancer and macular degeneration, by administering these compounds.Type: GrantFiled: July 16, 2010Date of Patent: April 10, 2012Assignee: The Children's Medical Center CorporationInventors: Anthony Treston, Jamshed H. Shah, Robert J. D'Amato, Kimberly A. Hunsucker, John Rougas, Barry P. Conner, Victor Pribdula, Glenn M. Swartz
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Publication number: 20110318393Abstract: Provided are substituted pyrazole compounds which are useful as protein kinase inhibitors, compositions comprising the compounds, and methods of use thereof. The protein kinase inhibitors are particularly for inhibition of Aurora A (Aurora-2) protein kinase and are useful in the treatment of diseases associated with protein kinases, especially diseases associated with Aurora-2, such as cancer.Type: ApplicationFiled: November 23, 2009Publication date: December 29, 2011Applicant: MIIKANA THERAPEUTICS, INC.Inventors: Gaetan Ladouceur, Gregory A. Agosto, Jamshed H. Shah, Lita Suwandi, Nnamdi Ofoegbu
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Publication number: 20100280249Abstract: The invention provides new and useful analogs of 4-amino-thalidomide. These analogs include S(?)-4-amino-thalidomide and R(+)-4-amino-thalidomide. The invention also provides processes for making these analogs. Further, the invention provides methods for inhibiting angiogenesis and treating angiogenesis-associated diseases, including cancer and macular degeneration, by administering these compounds.Type: ApplicationFiled: July 16, 2010Publication date: November 4, 2010Inventors: Anthony Treston, Jamshed H. Shah, Robert J. D'Amato, Kimberly A. Hunsucker, John Rougas, Barry P. Conner, Victor Pribdula, Glenn M. Swartz
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Patent number: 7812169Abstract: The invention provides new and useful analogs of 4-amino-thalidomide. These analogs include S(?)-4-amino-thalidomide and R(+)-4-amino-thalidomide. The invention also provides processes for making these analogs. Further, the invention provides methods for inhibiting angiogenesis and treating angiogenesis-associated diseases, including cancer and macular degeneration, by administering these compounds.Type: GrantFiled: November 30, 2001Date of Patent: October 12, 2010Assignee: The Children's Medical Center CorporationInventors: Anthony Treston, Jamshed H. Shah, Robert J. D'Amato, Kimberly A. Hunsucker, John Rougas, Barry P. Conner, Victor Pribdula, Glenn M. Swartz
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Patent number: 7524865Abstract: The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, the invention comprises the compound EM-138 and its use in the inhibition of angiogenesis and treatment of angiogenesis associate diseases, including the inhibition of tumor growth and metastasis.Type: GrantFiled: July 21, 2004Date of Patent: April 28, 2009Assignee: Celgene CorporationInventors: Robert J. D'Amato, Shawn J. Green, Glenn M. Swartz, Jr., Jamshed H. Shah, John Madsen
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Publication number: 20090105205Abstract: Compositions and methods for treating mammalian diseases or conditions characterized by undesirable angiogenesis by administering an effective amount of a compound of the formulae: wherein Ra is selected from —OCH3, —OCH2CH3 or —CCCH3; and Z is selected from >C(H)—OH, >C(H)—O-alkyl, >C(H)—O-sulfamate, where alkyl is a linear, branched and/or cyclic hydrocarbon chain comprising 1 to 10 carbons.Type: ApplicationFiled: December 22, 2008Publication date: April 23, 2009Applicant: ENTREMED, INC.Inventors: Gregory E. Agoston, Jamshed H. Shah, Lita Suwandi, Theresa M. LaVallee, Anthony M. Treston
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Patent number: 7498322Abstract: Compositions and methods for treating mammalian diseases or conditions characterized by undesirable angiogenesis by administering an effective amount of a compound of the formulae: wherein Ra is selected from —OCH3, —OCH2CH3 or —CCCH3; and Z is selected from >C(H)—OH, >C(H)—O-alkyl, >C(H)—O-sulfamate, where alkyl is a linear, branched and/or cyclic hydrocarbon chain comprising 1 to 10 carbons.Type: GrantFiled: March 11, 2005Date of Patent: March 3, 2009Assignee: EntreMed, Inc.Inventors: Gregory E. Agoston, Jamshed H. Shah, Lita Suwandi, Theresa M. LaVallee, Anthony M. Treston
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Publication number: 20080306113Abstract: Methods of treating, preventing and/or managing macular degeneration are disclosed. Specific embodiments encompass the administration of 4-(amino)-2-(2,6-dioxo(3-piperidyl))-isoindoline-1,3-dione, or a pharmaceutically acceptable salt, solvate or stereoisomer thereof, alone or in combination with a second active agent and/or surgery.Type: ApplicationFiled: April 22, 2008Publication date: December 11, 2008Inventors: Anthony Treston, Jamshed H. Shah, Robert J. D'Amato, Kimberly A. Hunsucker, John Rougas, Barry P. Conner, Victor Pribdula, Glenn M. Swartz
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Patent number: 7371741Abstract: Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering compounds of the general formula: wherein the variables are defined in the specification.Type: GrantFiled: May 28, 2004Date of Patent: May 13, 2008Assignee: EntreMed, Inc.Inventors: Gregory E. Agoston, Theresa M. LaVallee, Victor S. Pribluda, Jamshed H. Shah, Anthony M. Treston
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Patent number: 7235540Abstract: 2-methoxyestradiol having greater than 98% purity is obtained by synthetic or purification methods. This highly pure 2-methoxy estradiol, lacking estrogenic components, is particularly suitable for clinical use in humans. The purification methods of the invention involve the use of liquid-solid chromatography (LSC) to separate 2-ME2 from other compounds. The chromatographic media is preferably silica. The solvent system comprises a non-polar solvent, such as chloroform, and a polar solvent, such as methanol.Type: GrantFiled: September 26, 2005Date of Patent: June 26, 2007Assignee: EntreMed, Inc.Inventors: Gregory E. Agoston, Jamshed H. Shah, Anthony M. Treston
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Patent number: 7153867Abstract: The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, nitrogen-substituted thalidomide analogs and di-substituted thalidomide analogs have been shown to inhibit angiogenesis. Importantly, these compounds can be administered orally.Type: GrantFiled: August 6, 2002Date of Patent: December 26, 2006Assignee: Celgene CorporationInventors: Jamshed H. Shah, Barry P. Conner, Glenn M. Swartz, Kimberly A. Hunsucker, John Rougas, Robert J. D'Amato, Victor Pribluda, Anthony Treston
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Patent number: 7135581Abstract: Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering derivatives of 2-methoxyestradiol of the general formula: wherein the variables are defined in the specification.Type: GrantFiled: August 24, 2001Date of Patent: November 14, 2006Assignee: Entremed, Inc.Inventors: Gregory E. Agoston, Jamshed H. Shah, Kimberly A. Hunsucker, Victor S. Pribluda, Theresa M. LaVallee, Shawn J. Green, Christopher J. Herbstritt, Xiaoguo H. Zhan, Anthony M. Treston
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Patent number: 7112602Abstract: The invention provides new and useful analogs of 2-phthalimidinoglutaric acid. These analogs include DL-2-methyl-2-phthalimidinoglutaric acid and hydroxylated analogs of 2-phthalimidinoglutaric. The invention also provides processes for making these analogs. The invention also provides the two individual enantiomers of DL-2-methyl-2-phthalimidinoglutaric acid, (R)-(+)-2-methyl-2-phthalimidinoglutaric acid and (S)-(?)-2-methyl-2-phthalimidinoglutaric acid, and processes for separating these individual enantiomers from the racemate. Further, the invention provides methods for inhibiting angiogenesis and treating angiogenesis-associated diseases, including cancer and macular degeneration, by administering one or more of these compounds.Type: GrantFiled: December 9, 2003Date of Patent: September 26, 2006Assignee: The Children's Medical Center CorporationInventors: Robert J. D'Amato, Shawn J. Green, John W. Madsen, William Fogler, Glenn M. Swartz, Jr., Adonia E. Papathanassiu, Jamshed H. Shah
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Patent number: 7087592Abstract: 2-methoxyestradiol having greater than 98% purity is obtained by synthetic or purification methods. This highly pure 2-methoxy estradiol, lacking estrogenic components, is particularly suitable for clinical use in humans. The purification methods of the invention involve the use of liquid-solid chromatography (LSC) to separate 2-ME2 from other compounds. The chromatographic media is preferably silica. The solvent system comprises a non-polar solvent, such as chloroform, and a polar solvent, such as methanol.Type: GrantFiled: August 23, 2000Date of Patent: August 8, 2006Assignee: Entre Med, Inc.Inventors: Gregory E. Agoston, Jamshed H. Shah, Anthony M. Treston
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Publication number: 20040147558Abstract: The invention provides new and useful analogs of 3-amino-thalidomide. These analogs include S(−)-3-amino-thalidomide and R(+)-3-amino-thalidomide. The invention also provides processes for making these analogs. Further, the invention provides methods for inhibiting angiogenesis and treating angiogenesis-associated diseases, including cancer and macular degeneration, by administering these compounds.Type: ApplicationFiled: March 11, 2004Publication date: July 29, 2004Inventors: Anthony Treston, Jamshed H Shah, Robert J D'Amato, Kimberly A Hunsucker, John Rougas, Barry P Conner, Victor Pribdula, Glenn M Swartz
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Publication number: 20040127545Abstract: The invention provides new and useful analogs of 2-phthalimidinoglutaric acid. These analogs include DL-2-methyl-2-phthalimidinoglutaric acid and hydroxylated analogs of 2-phthalimidinoglutaric. The invention also provides processes for making these analogs. The invention also provides the two individual enantiomers of DL-2-methyl-2-phthalimidinoglutaric acid, (R) (+)-2-methyl-2-phthalimidinoglutaric acid and (S)-(−)-2-methyl-2-phthalimidinoglutaric acid, and processes for separating these individual enantiomers from the racemate. Further, the invention provides methods for inhibiting angiogenesis and treating angiogenesis-associated diseases, including cancer and macular degeneration, by administering one or more of these compounds.Type: ApplicationFiled: December 9, 2003Publication date: July 1, 2004Applicant: Childrens' Medical CorporationInventors: Robert J. D'Amato, Shawn J. Green, John W. Madsen, William Fogler, Glenn M. Swartz, Adonia E. Papathanassiu, Jamshed H. Shah
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Publication number: 20040097479Abstract: 2-methoxyestradiol having greater than 98% purity is obtained by synthetic or purification methods. This highly pure 2-methoxy estradiol, lacking estrogenic components, is particularly suitable for clinical use in humans. The purification methods of the invention involve the use of liquid-solid chromatography (LSC) to separate 2-ME2 from other compounds. The chromatographic media is preferably silica. The solvent system comprises a non-polar solvent, such as chloroform, and a polar solvent, such as methanol.Type: ApplicationFiled: July 1, 2003Publication date: May 20, 2004Inventors: Gregory E. Agoston, Jamshed H. Shah, Anthony M. Treston
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Patent number: 6673828Abstract: The invention provides new and useful analogs of 2-phthalimidinoglutaric acid. These analogs include DL-2-methyl-2-phthalimidinoglutaric acid and hydroxylated analogs of 2-phthalimidinoglutaric. The invention also provides processes for making these analogs. The invention also provides the two individual enantiomers of DL-2-methyl-2-phthalimidinoglutaric acid, (R)-(+)-2-methyl-2-phthalimidinoglutaric acid and (S)-(−)-2-methyl-2-phthalimidinoglutaric acid, and processes for separating these individual enantiomers from the racemate. Further, the invention provides methods for inhibiting angiogenesis and treating angiogenesis-associated diseases, including cancer and macular degeneration, by administering one or more of these compounds.Type: GrantFiled: May 11, 1999Date of Patent: January 6, 2004Assignee: Children's Medical Center CorporationInventors: Shawn J. Green, Glenn M. Swartz, Jr., Jamshed H. Shah, John Madsen, Adonia E. Papathanassiu, William Fogler
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Publication number: 20030236439Abstract: Compounds, compositions, and methods for treating disease states characterized by undesirable angiogenesis, proliferative activity, or cell mitosis by administering non-steroidal analogs of 2-methoxyestradiol of the general formula: 1Type: ApplicationFiled: January 30, 2003Publication date: December 25, 2003Inventors: Gregory Agoston, Jamshed H. Shah, Kimberly A. Hunsucker, Anthony M. Treston, Victor S. Pribluda