Patents by Inventor Jan A. Rafalski

Jan A. Rafalski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for detection of non-denatured nucleic acid fragments
    Patent number: 6037127
    Abstract: A method for detecting the presence of a nucleic acid analyte in a test sample is provided in which a test sample is contacted with a test strip of a chromatographic bibulous porous material which is capable of moving the test sample laterally along the test strip by capillary migration to ultimate capture by a moiety in a specific capture zone.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: March 14, 2000
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Richard C. Ebersole, Edwin R. Hendrickson, Mark S. Payne, Sandra Fitzpatrick-McElligott, William R. Majarian, Jan A. Rafalski
  • Process for detecting polymorphisms on the basis of nucleotide differences
    Patent number: 5126239
    Abstract: A process is provided for detecting polymorphisms on the basis of nucleotide differences in random segments of the nucleic acid by performing a primer extension reaction on the nucleic acids and comparing the extension reaction products. The random nucleic acid segment can be amplified by first dissociating the extension product from the template and contacting the dissociated extension product with a primer under conditions such that an amplification extension product is synthesized using the dissociated extension product as a template. Differences in the extension product are useful as markers in constructing genetic maps and as markers to distinguish or identify individuals.
    Type: Grant
    Filed: March 14, 1990
    Date of Patent: June 30, 1992
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Kenneth J. Livak, Jan A. Rafalski, Scott V. Tingey, John G. Williams