Abstract: The present invention relates to antibodies against the human 5T4 oncofoetal antigen and corresponding antibody-drug conjugates that are suitable for testing in clinical trials. The antibodies are cross-reactive for humans and cynomolgus monkeys and exhibit an affinity for human 5T4 antigen which is in the same order of magnitude as their affinity for cynomolgus monkey 5T4 antigen. The invention further relates to the use of the antibodies and corresponding ADCs in the treatment of solid tumours and haematological malignancies.

Abstract: The present invention relates to antibodies against the human 5T4 oncofoetal antigen and corresponding antibody-drug conjugates that are suitable for testing in clinical trials. The antibodies are cross-reactive for humans and cynomolgus monkeys and exhibit an affinity for human 5T4 antigen which is in the same order of magnitude as their affinity for cynomolgus monkey 5T4 antigen. The invention further relates to the use of the antibodies and corresponding ADCs in the treatment of solid tumours and haematological malignancies.

Abstract: The present disclosure relates to CDR defined antibodies targeting the 5T4 oncofoetal antigen (TPBG, 5T4, Wnt Activated Inhibitory Factor 1, WAIF1) which exhibit a binding affinity for human 5T4 antigen which is in the same order of magnitude as their affinity for cynomolgus monkey 5T4. Antibody-drug conjugates (ADCs), and their use in the treatment of human solid tumours and haematological malignancies are claimed.

Abstract: Disclosed is a cutting device and a method for cutting a continuous strip into tire components. The cutting device includes a knife for cutting the continuous strip along a cutting line in a working plane and a feeding assembly with a feeding member for feeding the continuous strip in the working plane to the knife in a feeding direction that intersects with the cutting line at a cutting angle. The feeding member, and the knife are rotatable with respect to each other about a rotation axis perpendicular to the working plane for adjusting the cutting angle. The feeding assembly further includes an input member for receiving the continuous strip in an input direction into the cutting device and one or more guide members for guiding the continuous strip from the input member to the feeding member, wherein the input member is placed in line with or substantially in line with the rotation axis.

Abstract: Disclosed is a cutting device and a method for cutting a continuous strip into tire components. The cutting device includes a knife for cutting the continuous strip along a cutting line in a working plane and a feeding assembly with a feeding member for feeding the continuous strip in the working plane to the knife in a feeding direction that intersects with the cutting line at a cutting angle. The feeding member and the knife are rotatable with respect to each other about a rotation axis perpendicular to the working plane for adjusting the cutting angle. The feeding assembly further includes an input member for receiving the continuous strip in an input direction into the cutting device and one or more guide members for guiding the continuous strip from the input member to the feeding member, wherein the input member is placed in line with or substantially in line with the rotation axis.

Abstract: The present disclosure relates to CDR defined antibodies targeting the 5T4 oncofoetal antigen (TPBG, 5T4, Wnt Activated Inhibitory Factor 1, WAIF1) which exhibit a binding affinity for human 5T4 antigen which is in the same order of magnitude as their affinity for cynomolgus monkey 5T4. Antibody-drug conjugates (ADCs), and their use in the treatment of human solid tumours and haematological malignancies are claimed.

Abstract: The present invention relates to a polyacylurethane having the following general formula (I) and a process for the preparation of such polyacylurethane. Preferred embodiments of the polyacylurethanes according to the invention have elastomeric properties. The polyacylurethanes can suitable be used in biodegradable, biocompatible and/or biomedical devices.

Abstract: The present invention relates to a polyacylurethane having the following general formula (I) and a process for the preparation of such polyacylurethane. Preferred embodiments of the polyacylurethanes according to the invention have elastomeric properties. The polyacylurethanes can suitable be used in biodegradable, biocompatible and/or biomedical devices.

Abstract: The gross calorific value of the fuel gas and its density under normal conditions are recorded. Furthermore, the carbon dioxide content of the fuel gas is measured. The gas composition can be reliably determined from these three parameters without the use of a gas chromatograph.

Abstract: The fuel gas or a substream of the fuel gas is passed through a volumetric flowmeter and the volumetric gas flow is measured. In addition, the pressure, temperature and the proportion of at least one inert gas as well as the density and the dielectric constant are measured under reference conditions. The amount of heat supplied to gas consumption devices can be determined from these six parameters reliably without complicated technology.