Patents by Inventor Jan-Ake Skoldback

Jan-Ake Skoldback has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of cyclic peptides
    Patent number: 5990273
    Abstract: A process for preparing and purifying cyclic peptides having disulfide moieties in a two step processing operation including reverse phase chromatography which simplifies synthesis and reduces production costs, yet produces high, quality yield. The improved process is particularly useful for the preparation of vasopressin and oxytocin and their respective derivatives and analogs.
    Type: Grant
    Filed: November 10, 1997
    Date of Patent: November 23, 1999
    Assignee: Ferring B.V.
    Inventors: Lars Henrik Harald Andersson, Jan-Ake Skoldback
  • Desmopressin for nocturia, incontinence and enuresis
    Patent number: 5985835
    Abstract: A process for the manufacture of high purity desmopressin produced in single batches of substantial size and a method of treating nocturia, incontinence and enuresis with the high purity desmopressin produced therefrom.
    Type: Grant
    Filed: July 13, 1997
    Date of Patent: November 16, 1999
    Assignee: Ferring B.V.
    Inventors: Krister Larsson, Thomas Mellbrand, Birgitta Mornstam, Jan Roschester, Jan-Ake Skoldback, Ragner Asplund, Jens-Peter N.o slashed.rgaard
  • High-purity desmopressin produced in large single batches
    Patent number: 5763407
    Abstract: A process for the manufacture of high purity desmopressin produced in single batches of substantial size and a method of treating diabetes insipidus with the high purity desmopressin produced therefrom.
    Type: Grant
    Filed: February 10, 1997
    Date of Patent: June 9, 1998
    Assignee: Ferring BV
    Inventors: Krister Larsson, Thomas Mellbrand, Birgitta Mornstam, Jan Roschester, Jan-Ake Skoldback
  • Synthesis of cyclic peptides
    Patent number: 5726287
    Abstract: A process for preparing and purifying cyclic peptides having disulfide moieties in a single processing operation which simplifies synthesis and reduces production costs, yet produces high, quality yield. Higher yields are obtained by isolating the desired cyclic compound through direct ion exchange chromatography as an integral part of the single process. The improved process is particularly useful for the preparation of vasopressin and oxytocin and their respective derivatives and analogs.
    Type: Grant
    Filed: June 20, 1996
    Date of Patent: March 10, 1998
    Assignee: Ferring AB
    Inventors: Lars Henrik Harald Andersson, Jan-Ake Skoldback
  • High purity desmopressin produced in large single batches
    Patent number: 5674850
    Abstract: A process for the manufacture of high purity desmopressin produced in single batches of substantial size and a method of treating diabetes insipidus with the high purity desmopressin produced therefrom.
    Type: Grant
    Filed: September 7, 1995
    Date of Patent: October 7, 1997
    Assignee: Ferring AB
    Inventors: Krister Larsson, Thomas Mellbrand, Birgitta Mornstam, Jan Roschester, Jan-Ake Skoldback
  • Synthesis of cyclic peptides
    Patent number: 5596078
    Abstract: A process for preparing and purifying cyclic peptides having disulfide moieties in a single processing operation which simplifies synthesis and reduces production costs, yet produces high, quality yield. Higher yields are obtained by isolating the desired cyclic compound through direct ion exchange chromatography as an integral part of the single process. The improved process is particularly useful for the preparation of vasopressin and oxytocin and their respective derivatives and analogs.
    Type: Grant
    Filed: April 18, 1995
    Date of Patent: January 21, 1997
    Assignee: Ferring AB
    Inventors: Lars H. H. Andersson, Jan-Ake Skoldback
  • Process for manufacture of 1-deamino-8-D-arginine vasopressin
    Patent number: 5500413
    Abstract: A process for the manufacture of 1-deamino-8-D-arginine vasopressin (DDAVP) comprising, condensing a preparation of Mpa(R.sup.1)-Tyr-Phe-Gln-Asn-Cys(R.sup.2)-Pro-OH (SEQ ID NO: 1), where R.sup.1 and R.sup.2 are sulfhydryl-protecting groups, with the dipeptide (R.sup.3)-D-Arg(HCl)-Gly-NH.sub.2, where R.sup.3 is an acid-sensitive amino-protecting group, to form Mpa(R.sup.1)-Tyr-Phe-Gln-Asn-Cys(R.sup.2)-Pro-D-Arg(HCl)-Gly-NH.sub.2 (SEQ ID NO: 1), which is oxidized with iodine in a protic solvent. The reaction mixture containing the oxidized product can be purified by ion exchange chromatography on a cation exchange resin equilibrated with acid. Also disclosed is high-purity DDAVP obtained by this process and its use for treating diurea.
    Type: Grant
    Filed: June 29, 1993
    Date of Patent: March 19, 1996
    Assignee: Ferring AB
    Inventors: Krister Larsson, Thomas Mellbrand, Birgitta Mornstam, Jan Roschester, Jan-Ake Skoldback