Abstract: Disclosed is a dental appliance composed of a thermo-plastic polymer with low compressibility, high toughness, and high tensile strength, with a low softening point. The appliance has perforations that enable it to be easily custom-fitted by the user or a health professional. The appliance begins as an unformed dental tray that is significantly thinner than existing dental appliances. Once fitted, the dental appliance provides superior protection against damage to the enamel of the teeth and abrasion of the teeth due to bruxism or other mechanism leading to biomechanical wear of dental surfaces. The perforations facilitate the custom-fitting process by allowing the user to suck air through the perforations, thus applying a negative pressure between the material and the teeth while the material is still soft and pliable.

Abstract: Disclosed is a dental appliance composed of a thermo-plastic polymer with low compressibility, high toughness, and high tensile strength, with a low softening point. The appliance has perforations that enable it to be easily custom-fitted by the user or a health professional. The appliance begins as an unformed dental tray that is significantly thinner than existing dental appliances. Once fitted, the dental appliance provides superior protection against damage to the enamel of the teeth and abrasion of the teeth due to bruxism or other mechanism leading to biomechanical wear of dental surfaces. The perforations facilitate the custom-fitting process by allowing the user to suck air through the perforations, thus applying a negative pressure between the material and the teeth while the material is still soft and pliable.

Abstract: Disclosed is a dental appliance composed of a thermo-plastic polymer with low compressibility, high toughness, and high tensile strength, with a low softening point. The appliance has perforations that enable it to be easily custom-fitted by the user or a health professional. The appliance begins as an unformed dental tray that is significantly thinner than existing dental appliances. Once fitted, the dental appliance provides superior protection against damage to the enamel of the teeth and abrasion of the teeth due to bruxism or other mechanism leading to biomechanical wear of dental surfaces. The perforations facilitate the custom-fitting process by allowing the user to suck air through the perforations, thus applying a negative pressure between the material and the teeth while the material is still soft and pliable. This enables a user or health professional to within minutes create a final product that rivals the quality and fit of an appliance made by dental laboratories using dentist made impressions.

Abstract: Disclosed is a dental appliance composed of a thermo-plastic polymer with low compressibility, high toughness, and high tensile strength, with a low softening point. The appliance has perforations that enable it to be easily custom-fitted by the user or a health professional. The appliance begins as a generally U-shaped, unformed dental tray that is significantly thinner than existing dental appliances. Once fitted, the dental appliance provides superior protection against damage to the enamel of the teeth and abrasion of the teeth due to bruxism or other mechanism leading to biomechanical wear of dental surfaces. The perforations facilitate the custom-fitting process by allowing the user to suck air through the perforations, thus applying a negative pressure between the material and the teeth while the material is still soft and pliable.

Abstract: A dental appliance is disclosed designed to protect a wearer's dentitions against injury from impacts suffered in sports or other activities that can cause chipping, fracturing, dislodging or evulsion of teeth. The appliance may be custom-fittable with at least one pocket having an energy absorbing fluid. The energy absorbing fluid be nanosuspensions of small particles in viscous fluids that can undergo shear thickening when the dental appliance is struck by an object. The appliance dampens and diffuses horizontal and axial forces and directs them away from dentitions thereby reducing the risk for dental injuries.

Abstract: A mouth guard composed of a polymer consisting essentially of polycaprolactone exhibits a low softening point, enabling it to be easily custom-fitted by the user or a health professional. The material is provided in the form of a generally U-shaped, unformed sheet of material, enabling the material to be heated with hot water or microwave energy and custom-fitted to the dentition of a user. The mouth guard may be perforated and may include a no-stick layer and/or a flavoring agent. A plurality of mouth guards may be provided in different sizes for children and adults and different shapes for different sports. In the preferred embodiments the mouth guard has a periphery including a plurality of lobes and cusps to enhance fitting. A method of fabricating an improved mouth guard according to the invention is also disclosed.

Abstract: A dental appliance is disclosed designed to protect a wearer's dentitions against injury from impacts suffered in sports or other activities that can cause chipping, fracturing, dislodging or evulsion of teeth. The appliance may be custom-fittable with at least one pocket having an energy absorbing fluid. The energy absorbing fluid be nanosuspensions of small particles in viscous fluids that can undergo shear thickening when the dental appliance is struck by an object. The appliance dampens and diffuses horizontal and axial forces and directs them away from dentitions thereby reducing the risk for dental injuries.

Abstract: A dental appliance is disclosed designed to protect a wearer's dentitions against injury from impacts suffered in sports or other activities that can cause chipping, fracturing, dislodging or evulsion of teeth. The appliance may be custom-fittable with at least one pocket having an energy absorbing fluid. The energy absorbing fluid be nanosuspensions of small particles in viscous fluids that can undergo shear thickening when the dental appliance is struck by an object. The appliance dampens and diffuses horizontal and axial forces and directs them away from dentitions thereby reducing the risk for dental injuries.

Abstract: A dental appliance for protecting teeth has two front flaps separated by a forward cusp, and two side flaps separated from the forward front flaps by side cusps. An open area is provided in each of the forward front flaps. The appliance may also have a rear palate portion with a rear cusp. The appliance may have a line of symmetry that extends from the forward cusp to the rear cusp. Open spaces may be distributed throughout the sheet of material. A method of protecting the dentition of a patient during a transoral procedure or intubation includes the steps of providing the appliance in a planar first state and placing the appliance in the mouth of a patient so the patient's dentition crowns are located along a bite line on the appliance. The method also includes molding the appliance into a second, non-planar state to conform to the patient's dentition and palate so that the dentition are protected during the transoral procedure or intubation.

Abstract: A dental appliance for protecting teeth has two front flaps separated by a forward cusp, and two side flaps separated from the forward front flaps by side cusps. An open area is provided in each of the forward front flaps. The appliance may also have a rear palate portion with a rear cusp. The appliance may have a line of symmetry that extends from the forward cusp to the rear cusp. Open spaces may be distributed throughout the sheet of material. A method of protecting the dentition of a patient during a transoral procedure or intubation includes the steps of providing the appliance in a planar first state and placing the appliance in the mouth of a patient so the patient's dentition crowns are located along a bite line on the appliance. The method also includes molding the appliance into a second, non-planar state to conform to the patient's dentition and palate so that the dentition are protected during the transoral procedure or intubation.

Abstract: A dental appliance is disclosed designed to protect a wearer's dentitions against injury from impacts suffered in sports or other activities that can cause chipping, fracturing, dislodging or evulsion of teeth. The appliance may be custom-fittable with at least one pocket having an energy absorbing fluid. The energy absorbing fluid be nanosuspensions of small particles in viscous fluids that can undergo shear thickening when the dental appliance is struck by an object. The appliance dampens and diffuses horizontal and axial forces and directs them away from dentitions thereby reducing the risk for dental injuries.

Abstract: Disclosed is a dental appliance composed of a thermo-plastic polymer with low compressibility, high toughness, and high tensile strength, with a low softening point. The appliance has perforations that enable it to be easily custom-fitted by the user or a health professional. The appliance begins as a generally U-shaped, unformed dental tray that is significantly thinner than existing dental appliances. Once fitted, the dental appliance provides superior protection against damage to the enamel of the teeth and abrasion of the teeth due to bruxism or other mechanism leading to biomechanical wear of dental surfaces. The perforations facilitate the custom-fitting process by allowing the user to suck air through the perforations, thus applying a negative pressure between the material and the teeth while the material is still soft and pliable.

Abstract: A method for predicting the response to treatment in a patient suffering from a head or neck cancer including: obtaining a biological sample for the patient; measuring the expression level of several gene and using the measurement to predict a patient's response to treatment. The methods may include predicting the treatment response in a patient having virally-induced head or neck cancer; and/or using the prediction to treat the patient.

Abstract: The present invention provides methods and compositions for predicting patient responses to cancer treatment using the biomarkers: YAP-1, bcl-2, VEGF-c, c-met, and claudin-4.

Abstract: A mouth guard composed of a polymer consisting essentially of polycaprolactone exhibits a low softening point, enabling it to be easily custom-fitted by the user or a health professional. The material is provided in the form of a generally U-shaped, unformed sheet of material, enabling the material to be heated with hot water or microwave energy and custom-fitted to the dentition of a user. The mouth guard may be perforated and may include a no-stick layer and/or a flavoring agent. A plurality of mouth guards may be provided in different sizes for children and adults and different shapes for different sports. In the preferred embodiments the mouth guard has a periphery including a plurality of lobes and cusps to enhance fitting. A method of fabricating an improved mouth guard according to the invention is also disclosed.

Abstract: According to the present invention, a tumor to be surgically removed is coated with a tissue adhesive composition before resection thereof. Thus, the tissue adhesive composition functions as a protective membrane which aids to hold the tumor together during mechanical handling and resection thereof, thereby significantly reducing tumor spillage and the danger of subsequent implantation metastases.