Abstract: The present invention relates to a modified-release composition comprising orlistat and acarbose, comprising individually distinct parts with different release patterns: a) a first part, G1, comprising from about 5 to about 70% w/w of the total dose of acarbose, b) a second part, G2A, comprising from about 30 to about 95% w/w of the total dose of acarbose, c) a third part, G2B, comprising from about 10 to about 90% w/w of the total dose of orlistat, and d) a fourth part, G3, comprising from about 10 to about 80% w/w of the total dose of orlistat, and the total concentration of acarbose and orlistat, respectively, in the composition is 100% w/w.

Abstract: Bodies of silicon nitride are produced by enclosing a silicon nitride powder in a gas-tight glass casing and subjecting the casing to isostatic pressure using gas as a pressure medium at a temperature of at least 1600.degree. C. and a pressure of at least 100 MPa. The casing is a glass having a high softening point. The casing is evacuated and sealed before compressing. The product may be pre-formed by isostatic compacting at a pressure of at least 100 MPa at a temperature considerably below the sintering temperature. The casing is cooled at a rate of at most 1000.degree. C. per hour and at a pressure of not over 10 MPa.