Abstract: Provided herein are tumor-infiltrating lymphocytes (TILs) engineered to express a membrane-bound interleukin 15 (mbIL15). The mbIL15 TILs can be expanded in vitro using arapid expansion protocol without the use of exogenous interleukin 2 (IL2) and can be used in adoptive cell therapy without concomitant use of an exogenous cytokine such as IL2. The TIL can be further engineered such that the mbIL15 is operably linked to one or more drug responsive domains (DRDs), polypeptides that can regulate the abundance and/or activity of the IL15 upon binding of the DRD with a ligand. Also provided herein are components for making the modified TILs and methods for making and using the modified TILs.

Abstract: Disclosed embodiments are related to suspension systems including dampers and suspension actuators and related methods of control for mitigating the effects of potholes and other road surface discontinuities.

Abstract: A method for operating a fuel cell. The fuel cell is supplied with gaseous fuel via an anode-side gas feed line and with air via a cathode-side gas feed line. The anode-side gas feed line and the cathode-side gas feed line are coupled via a pressure-transmitting element, wherein in the event of an increased power requirement of the fuel cell, the gas pressure of the anode-side gas feed line is at least partly transmitted to the cathode-side gas feed line via the pressure-transmitting element and causes the gas pressure of the cathode-side gas feed line to increase. A fuel cell system having at least one fuel cell, an anode-side gas feed line, a cathode-side gas feed line, and a monitoring unit.

Abstract: A fuel cell device of a motor vehicle is disclosed. The fuel cell device includes a fuel cell, a supply air path leading to the fuel cell for a cathode supply air flow, and an exhaust air path leading away from the fuel cell for a cathode exhaust air flow. The supply air path and the exhaust air path are routed through a humidifier that humidifies the supply air and dehumidifies the exhaust air. The exhaust air path is further routed through a water separator that removes water from the exhaust air to provide evaporation water. A heat exchanger for cooling the fuel cell is provided that has an evaporative cooler for cooling the heat exchanger. The evaporative cooler is assigned to the water separator in fluidic communication and is supplied with evaporation water by the water separator.

Abstract: Disclosed embodiments are related to suspension systems including dampers and suspension actuators and related methods of control for mitigating the effects of potholes and other road surface discontinuities.

Abstract: A composite time series forecasting model comprising a neural network sub-model and one or more state space sub-models corresponding to individual time series is trained. During training, output of the neural network sub-model is used to determine parameters of the state space sub-models, and a loss function is computed using the values of the time series and probabilistic values generated as output by the state space sub-models. A trained version of the composite model is stored.

Abstract: Disclosed embodiments are related to suspension systems including dampers and suspension actuators and related methods of control for mitigating the effects of potholes and other road surface discontinuities.

Abstract: An input data set with a plurality of item descriptors comprising respective time series observations is identified. A routing directive indicating a predicate to be evaluated to determine whether a particular item descriptor is to be included in a training data set for a first learning algorithm is obtained. A plurality of learning algorithms are trained using training data sets derived from the input data set according to respective routing directives, and the trained algorithms are stored.

Abstract: With respect to an input data set which contains observation records of a time series, a statistical model which utilizes a likelihood function comprising a latent function is generated. The latent function comprises a combination of a deterministic component and a random process. Parameters of the model are fitted using approximate Bayesian inference, and the model is used to generate probabilistic forecasts corresponding to the input data set.

Abstract: Disclosed herein are methods and systems for modifying the posture of a vehicle, while traversing obstacles and/or steep slope transitions of a driving surface by, for example, adjusting approach, departure, and/or breakover angles by using one or more active suspension components.

Abstract: The invention concerns a vessel having a planing surface and a transom at a stern of the vessel, mounted on the transom is an interceptor and an actuator to move the interceptor in vertical direction. In accordance with the invention the transom defines a sharp edge with the planing surface and the underside of the interceptor comprises a convex rounded edge extending upwards to the rear with a leading edge of the convex rounded edge having a tangent approximately parallel to the water flow along the planing surface near the transom, and/or the transom defines a convex rounded edge with the planing surface with a leading edge of the convex rounded edge being tangent to the planing surface and the interceptor defines at its lowest part a sharp edge that can move behind the convex rounded edge in vertical direction.

Abstract: A ship whereby the hull and the mechanical propulsion device are designed such that the Froude number is larger than 0.5. In the aft ship the hull has a bottom with V-shaped bottom surfaces with a deadrise angle that is less than 40 degrees and the hull has substantially vertical sides. In the hull are a passenger compartment and a trim tank. The trim tank volume is such that the weight of a filled trim tank is more than 30% of the weight of displacement of the hull with an empty trim tank, filling the trim tank with water increases the amidships immersed width with at least 10%, and the bottom surfaces have bilge keels fully immersed when the trim tank is filled with water and the bilge keels are at least in part above the water level when the trim tank is empty.

Abstract: A model represents a cloud service to be provisioned over a cloud. A policy guides provisioning and subsequent management of the cloud service. The model is modified by introducing code corresponding to the policy into the model, the introduced code to perform at least one action with respect to a rule of the policy, the at least one action selected from among validating the rule and performing remediation with respect to the rule. Responsive to the modifying of the model, a set of instructions is generated including code for deploying an instance of the cloud service according to the model, and the introduced code to perform the at least one action with respect to the rule.

Abstract: A ship whereby the hull and the mechanical propulsion device are designed such that the Froude number is larger than 0.5. In the aft ship the hull has a bottom with V-shaped bottom surfaces with a deadrise angle that is less than 40 degrees and the hull has substantially vertical sides. In the hull are a passenger compartment and a trim tank. The trim tank volume is such that the weight of a filled trim tank is more than 30% of the weight of displacement of the hull with an empty trim tank, filling the trim tank with water increases the amidships immersed width with at least 10%, and the bottom surfaces have bilge keels fully immersed when the trim tank is filled with water and the bilge keels are at least in part above the water level when the trim tank is empty.

Abstract: The invention concerns a vessel having a planing surface and a transom at a stern of the vessel, mounted on the transom is an interceptor and an actuator to move the interceptor in vertical direction. In accordance with the invention the transom defines a sharp edge with the planing surface and the underside of the interceptor comprises a convex rounded edge extending upwards to the rear with a leading edge of the convex rounded edge having a tangent approximately parallel to the water flow along the planing surface near the transom, and/or the transom defines a convex rounded edge with the planing surface with a leading edge of the convex rounded edge being tangent to the planing surface and the interceptor defines at its lowest part a sharp edge that can move behind the convex rounded edge in vertical direction.

Abstract: The claims based identity model provides a model which associates security identities with claims. The model represents information contained in the claims, as well as, captures relationships between the security identities described in the claims. Finally, the data model can be easily translated to the existing .NET environment without breaking the backward compatibility for existing .NET applications.

Abstract: A method for maintaining the heading of a ship during movements caused by waves approaching the ship from a stern direction by activating a control surface in a bow of the ship such that the control surface converts a water flow along the bow into a lateral force that opposes roll, yaw, or heeling movements and course changes.

Abstract: A ship for use at high speed and/or heavy seas having a single long and slender hull, a sharp bow and the aft end of the hull has a flat or slightly V-shaped bottom with at least one aft rudder, and at least one propeller or water jet for propulsion whereby the foreship has a draught that is equal or more than the draught of the aft end. The bow has a control surface that converts the water flow along the forward moving ship into an adjustable lateral force.

Abstract: A method for maintaining the heading of a ship during movements caused by waves approaching the ship from a stern direction by activating a control surface in a bow of the ship such that the control surface converts a water flow along the bow into a lateral force that opposes roll, yaw, or heeling movements and course changes.

Abstract: A ship designed for use at high speed and heavy seas having a single long and slender hull with a narrow beam and a more or less vertical bow, whereby the front half of the hull has more or less vertical sides, minimal flare in the bow sections and towards the bow an increase in draught at its center line combined with a more or less similar increase of freeboard and whereby the aft end of the hull has a flat or slightly V-shaped bottom with one or more propellers and/or waterjets as propulsion means. In accordance with the invention the bow has a fillet radius of at least 1% of the beam.