Abstract: A method for the removal of arsenic in a positive oxidation stage from an aqueous liquid comprising the steps of: i) providing a porous adsorbent which comprises a solid phase carrying a metal ion in a form (I) which is capable of binding the arsenic to give a metal ion form (II) comprising the metal ion and the arsenic; ii) contacting the aqueous liquid with the adsorbent for formation of form (II), iii) separating the aqueous liquid from the adsorbent, iv) optionally regenerating the adsorbent, and reusing it in cycles comprising steps (i)-(iv), The characterizing feature is that A) form (I) is a metal chelate (I), which •comprises a metal ion and a multidentate chelating group, •comprises three or more amino nitrogens which are directly attached to sp3 carbon and in an at least triplet wise manner can coordinate a metal ion, and, •can be transformed to form (II), and/or B) step (ii) prior to the formation of form (II) comprises the substeps of: •oxidising As (+III) to As(+V), and •securing zero amounts of

Abstract: The present invention relates to a method of sterilizing a chromatography column which is packed with a separation matrix, which method comprises passing a superheated aqueous liquid through the packing of the column to obtain at least one substantially sterile packed chromatography column. The method may also comprise a preceding heating. In the most advantageous embodiment, the superheated aqueous liquid is passed in a substantially uniform flow through the packing of the column, resulting in a sterility of the packed column.

Abstract: The present invention relates to a method of sterilizing a chromatography column which is packed with a separation matrix, which method comprises passing a superheated aqueous liquid through the packing of the column to obtain at least one substantially sterile packed chromatography column. The method may also comprise a preceding heating. In the most advantageous embodiment, the superheated aqueous liquid is passed in a substantially uniform flow through the packing of the column, resulting in a sterility of the packed column.

Abstract: The present invention relates to a process for separating nucleic acid molecules, preferably open circular and supercoiled plasmid DNA and RNA molecules from each other, comprising the steps of providing a solution comprising the molecules; adsorbing the molecules to adsorbing groups on a carrier; and optionally washing the column with a suitable solution. The present process is especially suitable for large-scale isolation of supercoiled ccc DNA to be used in gene therapy.

Abstract: The present invention relates to a process for separating nucleic acid molecules, preferably open circular and super-coiled plasmid DNA and RNA molecules from each other, comprising the steps of providing a solution comprising the molecules; adsorbing the molecules to adsorbing groups on a carrier; and optionally washing the column with a suitable solution. The present process is especially suitable for large-scale isolation of supercoiled ccc DNA to be used in gene therapy.

Abstract: The present invention relates to a method for the removal of polyphenols and proteins simultaneously from a beverage by contacting the beverage with an ion exchanger that is capable of adsorbing both types of substances. The characteristic feature of the ion exchanger to be used is that it is a water-insoluble porous hydrophilic matrix to which ion exchanging groups are covalently bound.