Patents by Inventor Jan Bernard Frederik Nicolaas Engberts

Jan Bernard Frederik Nicolaas Engberts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polyhydroxy diamine surfactants and their use in gene transfer
    Patent number: 7005300
    Abstract: The use of carbohydrate-based surfactant compounds having the general formula (I): wherein Y1 and Y2, which may be the same or different, are carbohydrate groups; R1 and R2, which may be the same or different, are selected from: a) hydrogen; b) C(1-24) alkyl group; c) C(1-24) alkyl carboxy group; or d) a carbon chain of 2 to 24 carbon atoms having one or more carbon/carbon double bonds, and n is from 1 to 10; for facilitating the transfer of DNA or RNA polynucleotides, or analogs thereof, into a eukaryotic or prokaryotic cell in vivo or in vitro. New carbohydrate-based surfactant compounds are also disclosed.
    Type: Grant
    Filed: June 16, 2000
    Date of Patent: February 28, 2006
    Assignee: SmithKlineBeecham plc
    Inventors: Patrick Camilleri, Jan Bernard Frederik Nicolaas Engberts, Matthew Leigh Fielden, Andreas Kremer
  • Cationic amphiphiles as transfection vehicles
    Publication number: 20040259823
    Abstract: The invention relates to novel cationic amphiphiles having an aromatic ring comprising at least one nitrogen atom. The cationic amphiphiles are particularly useful for the introduction of biologically compounds such as DNA, RNA, proteins and the like into eukaryotic cells. The cationic amphiphiles are represented by the following basic formula:(I). Characteristic is that R1 and R2 ?are single C6-C24 carbon chains. For the mode of action it is assumed that R1 folds back over the aromatic ring towards R2.
    Type: Application
    Filed: June 17, 2004
    Publication date: December 23, 2004
    Inventors: Anthony Jacques Ronald Lambert Hulst, Jarmila Smisterova, Jan Bernard Frederik Nicolaas Engberts, Dirk Hoekstra
  • Transport vehicles for macromolecules
    Patent number: 6726894
    Abstract: The invention relates to new compounds with the general formula I for use as a tool to introduce macromolecules into cells. The invention further relates to compositions for introducing macromolecules into cells, comprising vesicles formed by at least one compound in a solvent. The macromolecule can be incorporated in the vesicles and/or bound to the vesicles or another aggregate of the new compounds.
    Type: Grant
    Filed: December 28, 1998
    Date of Patent: April 27, 2004
    Assignee: Synvolux IP B.V.
    Inventors: Jan Bernard Frederik Nicolaas Engberts, Anno Wagenaar, Dirk Hoekstra, Irene Van Der Woude, Marcel Herman Jozef Ruiters
  • Transport vehicles for macromolecules
    Patent number: 5853694
    Abstract: The invention relates to new compounds with the general formula I for use as a tool to introduce macromolecules into cells. The invention further relates to compositions for introducing macromolecules into cells, comprising vesicles formed by at least one compound in a solvent. The macromolecule can be incorporated in the vesicles and/or bound to the vesicles or another aggregate of the new compounds. In a preferred embodiment at least one targeting molecule, for instance a (labelled) antibody, may further be attached to the vesicles.
    Type: Grant
    Filed: July 24, 1996
    Date of Patent: December 29, 1998
    Assignees: Stitching Voor DeTechnische Wetenschappen, Rijksuniversiteit Groningen, Stichting Scheikundig Ondoerzoek in Nederland
    Inventors: Jan Bernard Frederik Nicolaas Engberts, Anno Wagenaar, Dirk Hoekstra, Irene Van Der Woude, Marcel Herman Jozef Ruiters