Abstract: The present invention relates to a heat exchanger, comprising: a first conduit circuit for guiding a first fluid; a second conduit circuit for guiding a second fluid; wherein the first conduit circuit and the second conduit circuit are both arranged in a heat-conducting material which is provided on a first side with fins; wherein the first conduit circuit substantially defines a plane arranged substantially parallel to and close to the first side of the heat-conducting material; wherein the second conduit circuit is arranged substantially along the first conduit circuit; wherein the second conduit circuit extends substantially along only a limited part of the plane defined by the first conduit circuit. The invention further relates to a hot water device and hot water system provided with such a heat exchanger, and to a method for application thereof.

Abstract: The invention relates to a mixture supply system which is adapted for mounting in a hot water appliance and which is adapted to supply a combustible mixture to a burner of the hot water appliance, comprising a fuel feed for a fluid fuel, an oxidizer feed for a fluid oxidizer, a mixing chamber for mixing the fuel and the oxidizer in order to form the combustible mixture, a discharge for discharging the combustible mixture from the mixing chamber and a fan for urging the fuel and oxidizer from the respective feed to the mixing chamber, and urging the mixture therefrom to the discharge, wherein the fan is adapted to act directly on both the fuel and the oxidizer. The fan does not so much make use of an airflow with gas drawn in by a venturi, but gas is supplied separately to the fan.

Abstract: A device for heating a flowing medium (e.g., water), wherein the device comprises a heating module and a heat exchanger enclosed by an insulating material comprising a vacuum-packed core material. The heating module and the heat exchanger may further be received in a housing having a number of walls, wherein the vacuum-packed core material is arranged between one of the walls and the heating module and/or the heat exchanger.

Abstract: A heat exchanger is manufactured from a single piece of heat-conducting material and comprises fins for guiding a fluid and for transferring heat between the fluid and the heat exchanger, wherein between the fins are provided transverse fins which extend in a direction substantially transversely of the fins over a distance which is less than the distance between the fins and in a direction substantially transversely of the flow direction of the fluid, wherein the transverse fins are arranged alternately close to or on mutually adjacent fins in order to cause a fluid flowing between the fins to follow a meandering path between the fins, wherein the lateral direction lies substantially perpendicularly of the fins.

Abstract: The present invention relates to a hot water appliance comprising a heating member for heating water, a control unit for controlling the heating member, the control unit comprising a memory for storing a desired temperature of a space to be heated, and an input/output unit, wherein the input/output unit is adapted to receive a signal representative of a measured temperature, and wherein the control unit controls the heating member on the basis of the desired temperature and the measured temperature.

Abstract: The invention relates to a mixture supply system which is adapted for mounting in a hot water appliance and which is adapted to supply a combustible mixture to a burner of the hot water appliance, comprising a fuel feed for a fluid fuel, an oxidizer feed for a fluid oxidizer, a mixing chamber for mixing the fuel and the oxidizer in order to form the combustible mixture, a discharge for discharging the combustible mixture from the mixing chamber and a fan for urging the fuel and oxidizer from the respective feed to the mixing chamber, and urging the mixture therefrom to the discharge, wherein the fan is adapted to act directly on both the fuel and the oxidizer. The fan does not so much make use of an airflow with gas drawn in by a venturi, but gas is supplied separately to the fan.

Abstract: The present invention relates to an episomal structure expressing a functional oncogene, whereby said oncogene is a fusion gene of two chromosomal gene fragments. More specifically, the invention relates to a NUP214-ABL1 fusion product, important in the development of T-cell acute lymphoblastic leukemia, to methods to detect the fusion and to methods to prevent the oncogenic activity of said fusion product.

Abstract: Fan housing for a fan for supplying a fuel/oxidizer mixture to a burner, comprising: a supply opening (22); a fluid supply space (26) debouching at the supply opening; a first supply means (28) for supplying a fluid-like fuel; a second supply means (52) for supplying an oxidizing fluid; wherein the fluid supply space comprises mixing means (50) for mixing the fluid-like fuel with the oxidizing fluid; and wherein the supply opening lies at an angle relative to the supply direction of the fluid in the fluid supply space.

Abstract: The present invention relates to the field of biotechnological means to diagnose or treat T-cell acute lymphoblastic leukaemia. More particularly, the invention relates to methods to diagnose T-cell acute lymphoblastic leukaemia via determining the presence of a duplication of the MYB gene in cells taken from patients. The invention further relates to inhibitors capable of neutralizing the biological activity of MYB alone, or in combination with inhibitors capable of neutralizing the biological activity of NOTCH1, which can be used to treat T-cell acute lymphoblastic leukaemia.

Abstract: A heat exchanger (10) is manufactured from a single piece of heat-conducting material and comprises fins (20) for guiding a fluid and for transferring heat between the fluid and the heat exchanger, wherein between the fins are provided transverse fins (24) which extend in a direction substantially transversely of the fins over a distance which is less than the distance between the fins and in a direction substantially transversely of the flow direction of the fluid, wherein the transverse fins are arranged alternately close to or on mutually adjacent fins in order to cause a fluid flowing between the fins to follow a meandering path between the fins, wherein the lateral direction lies substantially perpendicularly of the fins.

Abstract: The present invention relates to an episomal structure expressing a functional oncogene, whereby said oncogene is a fusion gene of two chromosomal gene fragments. More specifically, the invention relates to a NUP214-ABL1 fusion product, important in the development of T-cell acute lymphoblastic leukemia, to methods to detect the fusion and to methods to prevent the oncogenic activity of said fusion product.

Abstract: The present invention relates to an episomal structure expressing a functional oncogene, whereby said oncogene is a fusion gene of two chromosomal gene fragments. More specifically, the invention relates to a NUP214-ABL1 fusion product, important in the development of T-cell acute lymphoblastic leukemia, to methods to detect the fusion and to methods to prevent the oncogenic activity of said fusion product.

Abstract: The present invention relates to the field of biotechnological means to diagnose or treat T-cell acute lymphoblastic leukaemia. More particularly, the invention relates to methods to diagnose T-cell acute lymphoblastic leukaemia via determining the presence of a duplication of the MYB gene in cells taken from patients. The invention further relates to inhibitors capable of neutralizing the biological activity of MYB alone, or in combination with inhibitors capable of neutralizing the biological activity of NOTCH1, which can be used to treat T-cell acute lymphoblastic leukaemia.

Abstract: The present invention relates to the use of midostaurin, in free form or in pharmaceutically acceptable salt form in the manufacture of a pharmaceutical composition for the treatment of gastrointestinal stromal tumors, and to a method of treatment of warm-blooded animals, preferably humans, in which a therapeutically effective dose of midostaurin is administered to an animal suffering from said disease or condition.

Abstract: The present invention relates to an episomal structure expressing a functional oncogene, whereby said oncogene is a fusion gene of two chromosomal gene fragments. More specifically, the invention relates to a NUP214-ABL1 fusion product, important in the development of T-cell acute lymphoblastic leukemia, to methods to detect the fusion and to methods to prevent the oncogenic activity of said fusion product.

Abstract: A method and apparatus coats a substrate with an inorganic-organic hybrid polymer material. The method generates and maintains a plasma according to the Dielectric Barrier Discharge (DBD) technique, method including the steps of introducing a sample in the space between two electrodes, generating a plasma discharge between the electrodes and admixing aerosols containing hybrid organic/inorganic cross-linked pre-polymers to the plasma discharge. Also, an apparatus generates the plasma and admixes the liquid coating material (precursor solution) in the form of aerosol to the plasma discharge.