Abstract: The present invention relates to an apparatus for demolding and analyzing a direct analysis sample formed from a molten metal material contained within a sample chamber assembly, wherein the sample chamber assembly comprises at least a sample housing, a cover plate and closing means, comprising: a cabinet defining an interior and comprising at least one opening for the sample housing to enter the cabinet, and analyzing means located inside the cabinet for analyzing an analysis surface of the sample; demolding means adapted to remove at least the closing means to expose at least part of the analysis surface of the sample; and transporting means adapted to hold and transport the sample housing at least between a sample demolding position, where the closing means is removed by the demolding means, and a sample analysis position, where the analysis surface of the sample is analyzed by the analyzing means, and wherein the sample demolding position and the sample analysis position are different from each other.

Abstract: The present invention relates to an apparatus for demolding and analyzing a direct analysis sample formed from a molten metal material contained within a sample chamber assembly, wherein the sample chamber assembly comprises at least a sample housing, a cover plate and closing means, comprising: a cabinet defining an interior and comprising at least one opening for the sample housing to enter the cabinet, and analyzing means located inside the cabinet for analyzing an analysis surface of the sample; demolding means adapted to remove at least the closing means to expose at least part of the analysis surface of the sample; and transporting means adapted to hold and transport the sample housing at least between a sample demolding position, where the closing means is removed by the demolding means, and a sample analysis position, where the analysis surface of the sample is analyzed by the analyzing means, and wherein the sample demolding position and the sample analysis position are different from each other.

Abstract: An immersion device is provided for molten metal, as well as a method for making steel. The immersion device allows a trouble free operation. The immersion device includes a measuring head, a carrier for the measuring head, and a lance detachably connected to the carrier, preferably by a detachable tubular connecting element. A gas path runs from the lance to the detachable tubular connecting element. A gas tight connection is provided between a connecting surface of the lance and the detachable tubular connecting element. The tubular connecting element has wipers in the form of fins, which wipe the connecting surface of the lance during attaching and/or detaching the tubular connecting element and the lance.

Abstract: An immersion device is provided for molten metal, as well as a method for making steel. The immersion device allows a trouble free operation. The immersion device includes a measuring head, a carrier for the measuring head, and a lance detachably connected to the carrier, preferably by a detachable tubular connecting element. A gas path runs from the lance to the detachable tubular connecting element. A gas tight connection is provided between a connecting surface of the lance and the detachable tubular connecting element. The tubular connecting element has wipers in the form of fins, which wipe the connecting surface of the lance during attaching and/or detaching the tubular connecting element and the lance.

Abstract: A sensor arrangement for melted materials includes an upper part and a detachable lower part. A tube extends coaxial to a longitudinal axis of the lower part, is closed on its end facing away from the upper part, and is open on the other end. The tube is arranged on an immersion end of the lower part facing away from the upper part. A guide tube, extending coaxial to a longitudinal axis of the upper part and being open on both ends, is arranged in a guide sleeve. A pressure acting in the direction of the lower part is applied to the guide tube by an elastic body and the guide tube touches against the lower part. One opening of the guide tube and the open end of the tube of the lower part are arranged adjacent to each other and coaxial to the longitudinal axis of the lower part.

Abstract: The present invention relates to an improved process for preparing (2R,3aR,10Z,11aS,12aR,14aR)-cyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a(1H)-carboxylic acid, 2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydro-2-[[7-methoxy-8-methyl-2-[4-(1-methylethyl)-2-thiazolyl]-4-quinolinyl]oxy]-5-methyl-4,14-dioxo-, ethyl ester. This compound is an intermediate in the overall synthesis route of the macrocyclic compound TMC 435. TMC 435 is an inhibitor of NS3/4A protease which plays an important role in the replication of the hepatitis C virus.

Abstract: The present invention relates to an improved process for preparing (2R,3aR,10Z,11aS,12aR,14aR)-cyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a(1H)-carboxylic acid, 2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydro-2-[[7-methoxy-8-methyl-2-[4-(1-methylethyl)-2-thiazolyl]-4-quinolinyl]oxy]-5-methyl-4,14-dioxo-, ethyl ester. This compound is an intermediate in the overall synthesis route of the macrocyclic compound TMC 435. TMC 435 is an inhibitor of NS3/4A protease which plays an important role in the replication of the hepatitis C virus.

Abstract: The present invention relates to an improved process for preparing (2R,3aR,10Z,11aS,2aR,14aR)-cyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a(1H)-carboxylic acid, 2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydro-2-[[7-methoxy-8-methyl-2-[4-10(1-methylethyl)-2-thiazolyl]-4-quinolinyl]oxy]-5-methyl-4,14-dioxo-, ethyl ester. This compound is an intermediate in the overall synthesis route of the macrocyclic compound TMC 435. TMC 435 is an inhibitor of NS3/4A protease which plays an important role in the replication of the hepatitis C virus.

Abstract: A sensor arrangement is provided for temperature measurement in melts, in particular in metal or cryolite melts having a melting point above 600° C., using a temperature sensor. A method for the measurement with this sensor arrangement is also provided.

Abstract: The present invention relates to an improved process for preparing (2R,3aR,10Z,11aS,2aR,14aR)-cyclopenta[c]cyc-lopropa[g][1,6]diazacyclotetradecine-12a(1H)-carboxylic acid, 2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydro-2[[7-methoxy-8-methyl-2-[4-10 (1-methylethyl)-2-thiazolyl]-4-quinolinyl]oxy]-5-methyl-4,14-dioxo-, ethyl ester. This compound is an intermediate in the overall synthesis route of the macrocyclic compound TMC 435. TMC 435 is an inhibitor of NS3/4A protease which plays an important role in the replication of the hepatitis C virus.

Abstract: A measuring device is provided for measurement of parameters, in particular for measuring the temperature, in molten masses, in particular in molten metal or molten cryolite masses having a melting point above 500° C. The measuring device has an optical fiber for receiving radiation from the molten mass and a cable reel having an external circumference for winding up the optical fiber and an internal space surrounded by the external circumference. A distributor and a mode filter for the optical fiber are arranged in the internal space.

Abstract: A sensor arrangement for melted materials includes an upper part and a detachable lower part. A tube extends coaxial to a longitudinal axis of the lower part, is closed on its end facing away from the upper part, and is open on the other end. The tube is arranged on an immersion end of the lower part facing away from the upper part. A guide tube, extending coaxial to a longitudinal axis of the upper part and being open on both ends, is arranged in a guide sleeve. A pressure acting in the direction of the lower part is applied to the guide tube by an elastic body and the guide tube touches against the lower part. One opening of the guide tube and the open end of the tube of the lower part are arranged adjacent to each other and coaxial to the longitudinal axis of the lower part.

Abstract: The present invention relates to a novel process, suitable for industrial exploitation for the production of N-(2,6-dimethyl-phenyl)-2-piperazin-1-yl-acetamide, also known as N-lidocaine, obtained from the reaction of piperazine with N-haloacetyl-2,6-xylidine. The process comprises the consecutive steps a) through f) a) reacting piperazine with N-haloacetyl-2,6-xylidine in a molar ratio between about 1/1 and about 6/1 in an aqueous solvent in which has been dissolved an equimolar amount of HCl; b) separating the solid formed in step a) from the reaction mixture; c) neutralizing the filtrate; d) extracting the filtrate with a solvent which is not or only to a small extent miscible with the aqueous solvent mentioned in step a); e) crystallizing the N-(2,6-dimethyl-phenyl)-2-piperazin-1-yl-acetamide from the solvent mentioned in step d) and f) separating the solid obtained in step e) from the solvent mentioned in step d).

Abstract: A measuring device is provided for measurement of parameters, in particular for measuring the temperature, in molten masses, in particular in molten metal or molten cryolite masses having a melting point above 500° C. The measuring device has an optical fiber for receiving radiation from the molten mass and a cable reel having an external circumference for winding up the optical fiber and an internal space surrounded by the external circumference. A distributor and a mode filter for the optical fiber are arranged in the internal space.

Abstract: A sensor arrangement is provided for temperature measurement in melts, in particular in metal or cryolite melts having a melting point above 600° C., using a temperature sensor. A method for the measurement with this sensor arrangement is also provided.

Abstract: Blister lights are used for signaling and/or marking purposes. The blister lights include a housing which is embedded in a traffic area, e.g. a street, an airport runway for taking off and for landing, or the like. It further includes a housing cover by which means the housing embedded in the traffic area can be closed on its upper side, the cover being detachably connected to the housing and including at least one light outlet. It additionally includes an illuminating element which is arranged in the housing and by which the light can radiate through the light outlet of the housing cover. In order to enable the illuminating element to have higher current densities and thus to enable the blister lights to have a higher light output capacity, a thermoconducting bridge is formed between illuminating element and the housing cover.

Abstract: A method is provided for calibrating measurement signals obtained with optical fibers, wherein a reference material having a known reference temperature is arranged at one end of an optical fiber, the reference material is heated up to at least its reference temperature, the signal received by the fiber when the reference temperature is reached is supplied as a calibration signal to a measurement device and is compared there with the theoretical value for the reference temperature, and the difference is used for calibration. In addition, a corresponding device is provided for using the above method for calibration or determination of the attenuation of an optical fiber.

Abstract: A method is provided for calibrating measurement signals obtained with optical fibers, wherein a reference material having a known reference temperature is arranged at one end of an optical fiber, the reference material is heated up to at least its reference temperature, the signal received by the fiber when the reference temperature is reached is supplied as a calibration signal to a measurement device and is compared there with the theoretical value for the reference temperature, and the difference is used for calibration. In addition, a corresponding device is provided for using the above method for calibration or determination of the attenuation of an optical fiber.

Abstract: Blister lights are used for signaling and/or marking purposes. The blister lights include a housing which is embedded in a traffic area, e.g. a street, an airport runway for taking off and for landing, or the like. It further includes a housing cover by which the housing embedded in the traffic area can be closed on its upper side, the cover being detachably connected to the housing and including at least one light outlet. It additionally includes an illuminating element which is arranged in the housing and by which the light can radiate through the light outlet of the housing cover. In order to enable the illuminating element to have higher current densities and thus to enable the blister lights to have a higher light output capacity, a thermoconducting bridge is formed between illuminating element and the housing cover.

Abstract: The present invention relates to a novel process, suitable for industrial exploitation for the production of N-(2,6-dimethyl-phenyl)-2-piperazin-1-yl-acetamide, also known as N-lidocaine, obtained from the reaction of piperazine with N-haloacetyl-2,6-xylidine. The process comprises the consecutive steps a) through f) a) reacting piperazine with N-haloacetyl-2,6-xylidine in a molar ratio between about 1/1 and about 6/1 in an aqueous solvent in which has been dissolved an equimolar amount of HCl; b) separating the solid formed in step a) from the reaction mixture; c) neutralizing the filtrate; d) extracting the filtrate with a solvent which is not or only to a small extent miscible with the aqueous solvent mentioned in step a); e) crystallizing the N-(2,6-dimethyl-phenyl)-2-piperazin-1-yl-acetamide from the solvent mentioned in step d) and f) separating the solid obtained in step e) from the solvent mentioned in step d).