Patents by Inventor Jan Egbert de Vries

Jan Egbert de Vries has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POLY-DONOR CD4+ T CELLS EXPRESSING IL-10 AND USES THEREOF
    Publication number: 20230302130
    Abstract: The present disclosure provides a population of poly-donor CD4IL-10 cells generated by genetically modifying CD4+ T cells from at least three different T cell donors. Further provided are methods of generating the poly-donor CD4IL-10 cells and methods of using the poly-donor CD4IL-10 cells for immune tolerization, treating GvHD, cell and organ transplantation, cancer, and other immune disorders.
    Type: Application
    Filed: June 28, 2021
    Publication date: September 28, 2023
    Inventors: Maria Grazia RONCAROLO, Jan Egbert DE VRIES
  • Method of reducing immunoglobulin E responses
    Patent number: 5676940
    Abstract: A method of reducing immunoglobulin E responses associated with certain immune disorders is provided. The method comprises administering an effective amount of an antagonist to human interleukin-4. Preferably, the antagonist is a blocking monoclonal antibody specific for human interleukin-4, or a fragment or binding composition derived therefrom.
    Type: Grant
    Filed: March 17, 1994
    Date of Patent: October 14, 1997
    Assignee: Schering Corporation
    Inventors: Robert L. Coffman, Jan Egbert de Vries