Patents by Inventor Jan Egil Melvik
Jan Egil Melvik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9463162Abstract: Kits and compositions for producing an alginate gel are disclosed. The kits and compositions comprise soluble alginate and insoluble alginate/gelling ion particles. Methods for dispensing a self-gelling alginate dispersion are disclosed. The methods comprise forming a dispersion of insoluble alginate/gelling ion particles in a solution containing soluble alginate, and dispensing the dispersion whereby the dispersion forms an alginate gel matrix. The methods may include dispensing the dispersion into the body of an individual. An alginate gel having a thickness of greater than 5 mm and a homogenous alginate matrix network and homogenous alginate gels free of one or more of: sulfates citrates, phosphates, lactatates, EDTA or lipids are disclosed. Implantable devices comprising a homogenous alginate gel coating are disclosed. Methods of improving the viability of pancreatic islets, or other cellular aggregates or tissue, following isolation and during storage and transport are disclosed.Type: GrantFiled: May 28, 2014Date of Patent: October 11, 2016Assignee: FMC Biopolymer ASInventors: Jan Egil Melvik, Michael Dornish, Edvar Onsoyen, Astrid B. Berge, Terje Svendsen
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Patent number: 9028872Abstract: The invention relates to composites comprising a polysaccharide gelled within pores of a foam, methods of preparation, and uses thereof, for example, in biomedical applications such as cell culture media and implants, controlled release delivery systems, food applications, industrial applications, and personal care applications such as cosmetic and oral hygiene. The composites of the present invention are simple to formulate using few steps and are useful for entrapping heat-sensitive components, such as cells, drugs, flavors or fragrances within the polysaccharide gel. In addition, the invention provides for a composite able to gently immobilize fragile components, such as living cells, without exposing such components to shear forces.Type: GrantFiled: March 1, 2007Date of Patent: May 12, 2015Assignee: FMC CorporationInventors: Olav Gaserod, Therese Andersen, Jan Egil Melvik, Michael Dornish, Peter J. Riley
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Publication number: 20140271576Abstract: Kits and compositions for producing an alginate gel are disclosed. The kits and compositions comprise soluble alginate and insoluble alginate/gelling ion particles. Methods for dispensing a self-gelling alginate dispersion are disclosed. The methods comprise forming a dispersion of insoluble alginate/gelling ion particles in a solution containing soluble alginate, and dispensing the dispersion whereby the dispersion forms an alginate gel matrix. The methods may include dispensing the dispersion into the body of an individual. An alginate gel having a thickness of greater than 5 mm and a homogenous alginate matrix network and homogenous alginate gels free of one or more of: sulfates citrates, phosphates, lactatates, EDTA or lipids are disclosed. Implantable devices comprising a homogenous alginate gel coating are disclosed. Methods of improving the viability of pancreatic islets, or other cellular aggregates or tissue, following isolation and during storage and transport are disclosed.Type: ApplicationFiled: May 28, 2014Publication date: September 18, 2014Applicant: FMC Biopolymer ASInventors: Jan Egil Melvik, Michael Dornish, Edvar Onsoyen, Astrid B. Berge, Terje Svendsen
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Patent number: 8809521Abstract: Dispersions that comprise insoluble alginate/gelling ion particles in an alginate solution, wherein the dispersion exhibits less than 10% of final gel storage modulus after one minute in the absence of addition of non-gelling cations are disclosed. Kits and compositions for making such dispersions are disclosed and methods for making and using the dispersions, and the components used in the dispersions are also disclosed.Type: GrantFiled: August 28, 2008Date of Patent: August 19, 2014Assignee: FMC Biopolymer ASInventors: Jan Egil Melvik, Jorunn E. Bjornstad, Terje Svendsen
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Patent number: 8741872Abstract: Kits and compositions for producing an alginate gel are disclosed. The kits and compositions comprise soluble alginate and insoluble alginate/gelling ion particles. Methods for dispensing a self-gelling alginate dispersion are disclosed. The methods comprise forming a dispersion of insoluble alginate/gelling ion particles in a solution containing soluble alginate, and dispensing the dispersion whereby the dispersion forms an alginate gel matrix. The methods may include dispensing the dispersion into the body of an individual. An alginate gel having a thickness of greater than 5 mm and a homogenous alginate matrix network and homogenous alginate gels free of one or more of: sulfates citrates, phosphates, lactates, EDTA or lipids are disclosed. Implantable devices comprising a homogenous alginate gel coating are disclosed. Methods of improving the viability of pancreatic islets, or other cellular aggregates or tissue, following isolation and during storage and transport are disclosed.Type: GrantFiled: June 28, 2013Date of Patent: June 3, 2014Assignee: FMC Biopolymer ASInventors: Jan Egil Melvik, Michael Dornish, Edvar Onsoyen, Astrid B. Berge, Terje Svendsen
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Publication number: 20130288998Abstract: Kits and compositions for producing an alginate gel are disclosed. The kits and compositions comprise soluble alginate and insoluble alginate/gelling ion particles. Methods for dispensing a self-gelling alginate dispersion are disclosed. The methods comprise forming a dispersion of insoluble alginate/gelling ion particles in a solution containing soluble alginate, and dispensing the dispersion whereby the dispersion forms an alginate gel matrix. The methods may include dispensing the dispersion into the body of an individual. An alginate gel having a thickness of greater than 5 mm and a homogenous alginate matrix network and homogenous alginate gels free of one or more of: sulfates citrates, phosphates, lactatates, EDTA or lipids are disclosed. Implantable devices comprising a homogenous alginate gel coating are disclosed. Methods of improving the viability of pancreatic islets, or other cellular aggregates or tissue, following isolation and during storage and transport are disclosed.Type: ApplicationFiled: June 28, 2013Publication date: October 31, 2013Applicant: FMC BIOPOLYMER ASInventors: Jan Egil Melvik, Michael Dornish, Edvar Onsoyen, Astrid B. Berge, Terje Svendsen
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Patent number: 8541017Abstract: Methods of inhibiting proliferation of a plurality of proliferating cells are disclosed. Methods of inhibiting cell overgrowth on compositions that are in an animal's body are disclosed. Methods of inhibiting cell overgrowth on a device that is in an animal's body are disclosed. Devices that have on their exterior surface an alginate matrix that comprises Strontium are disclosed. Compositions comprising an alginate body and alginate sheets that each comprise a single layer of cells coating the exterior surface of the alginate body are disclosed. Methods of preparing an artificial tissue are disclosed. Devices comprising cells encapsulated within an alginate matrix and/or maintained as a monolayer on an alginate body, and methods of making and using the same are disclosed. Methods of coating compositions and devices are disclosed.Type: GrantFiled: August 12, 2010Date of Patent: September 24, 2013Assignee: FMC Biopolymer ASInventors: Jan Egil Melvik, Michael Dornish
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Patent number: 8481695Abstract: Kits and compositions for producing an alginate gel are disclosed. The kits and compositions comprise soluble alginate and insoluble alginate/gelling ion particles. Methods for dispensing a self-gelling alginate dispersion are disclosed. The methods comprise forming a dispersion of insoluble alginate/gelling ion particles in a solution containing soluble alginate, and dispensing the dispersion whereby the dispersion forms an alginate gel matrix. The methods may include dispensing the dispersion into the body of an individual. An alginate gel having a thickness of greater than 5 mm and a homogenous alginate matrix network and homogenous alginate gels free of one or more of: sulfates citrates, phosphates, lactatates, EDTA or lipids are disclosed. Implantable devices comprising a homogenous alginate gel coating are disclosed. Methods of improving the viability of pancreatic islets, or other cellular aggregates or tissue, following isolation and during storage and transport are disclosed.Type: GrantFiled: August 13, 2010Date of Patent: July 9, 2013Assignee: FMC Biopolymer ASInventors: Jan Egil Melvik, Michael Dornish, Edvar Onsoyen, Astrid B. Berge, Terje Svendsen
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Publication number: 20120276066Abstract: Biostructures that comprises modified alginates entrapping one or more stem cells are discloses. The modified alginates comprise at least one alginate chain section to which is bonded by covalent bonding at least one cell attachment peptide. Pluralities of stem cells are also disclosed. Methods of preventing death of stem cells and cells differentiated there from are disclosed. Methods of preparing a plurality of stem cells are disclosed. Methods of treating an individual who has a degenerative disease, such as a neurological disorder, or injury involving nerve damage by administering stem cells to said individual are disclosed.Type: ApplicationFiled: June 12, 2012Publication date: November 1, 2012Applicant: FMC CORPORATIONInventors: Jan Engelsen Brinchmann, Katrine Bjornebek Fronsdal, Jan Egil Melvik
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Patent number: 8168215Abstract: The present invention is directed to cellular devices comprising a collagen matrix, cell layer, and gelled alginate layer, processes for producing the devices, methods of implanting the devices, and methods of treatment thereof.Type: GrantFiled: June 13, 2007Date of Patent: May 1, 2012Inventors: Denis Dufrane, Pierre Rene Raymond Gianello, Jan Egil Melvik
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Publication number: 20110053886Abstract: Dispersions that comprise insoluble alginate/gelling ion particles in an alginate solution, wherein the dispersion exhibits less than 10% of final gel storage modulus after one minute in the absence of addition of non-gelling cations are disclosed. Kits and compositions for making such dispersions are disclosed and methods for making and using the dispersions, and the components used in the dispersions are also disclosed.Type: ApplicationFiled: August 28, 2008Publication date: March 3, 2011Applicant: FMC CORPORATIONInventors: Jan Egil Melvik, Jorunn E. Bjornstad, Terje Svendsen
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Publication number: 20100304484Abstract: Methods of inhibiting proliferation of a plurality of proliferating cells are disclosed. Methods of inhibiting cell overgrowth on compositions that are in an animal's body are disclosed. Methods of inhibiting cell overgrowth on a device that is in an animal's body are disclosed. Devices that have on their exterior surface an alginate matrix that comprises Strontium are disclosed. Compositions comprising an alginate body and alginate sheets that each comprise a single layer of cells coating the exterior surface of the alginate body are disclosed. Methods of preparing an artificial tissue are disclosed. Devices comprising cells encapsulated within an alginate matrix and/or maintained as a monolayer on an alginate body, and methods of making and using the same are disclosed. Methods of coating compositions and devices are disclosed.Type: ApplicationFiled: August 12, 2010Publication date: December 2, 2010Applicant: FMC BIOPOLYMER ASInventors: Jan Egil Melvik, Michael Dornish
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Publication number: 20100303914Abstract: Kits and compositions for producing an alginate gel are disclosed. The kits and compositions comprise soluble alginate and insoluble alginate/gelling ion particles. Methods for dispensing a self-gelling alginate dispersion are disclosed. The methods comprise forming a dispersion of insoluble alginate/gelling ion particles in a solution containing soluble alginate, and dispensing the dispersion whereby the dispersion forms an alginate gel matrix. The methods may include dispensing the dispersion into the body of an individual. An alginate gel having a thickness of greater than 5 mm and a homogenous alginate matrix network and homogenous alginate gels free of one or more of: sulfates citrates, phosphates, lactatates, EDTA or lipids are disclosed. Implantable devices comprising a homogenous alginate gel coating are disclosed. Methods of improving the viability of pancreatic islets, or other cellular aggregates or tissue, following isolation and during storage and transport are disclosed.Type: ApplicationFiled: August 13, 2010Publication date: December 2, 2010Applicant: FMC Biopolymer ASInventors: Jan-Egil Melvik, Michael Dornish, Edvar Onsoyen, Astrid B. Berge, Terje Svendsen
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Publication number: 20100239540Abstract: Biostructures that comprises modified alginates entrapping one or more stem cells are discloses. The modified alginates comprise at least one alginate chain section to which is bonded by covalent bonding at least one cell attachment peptide. Pluralities of stem cells are also disclosed. Methods of preventing death of stem cells and cells differentiated there from are disclosed. Methods of preparing a plurality of stem cells are disclosed. Methods of treating an individual who has a degenerative disease, such as a neurological disorder, or injury involving nerve damage by administering stem cells to said individual are disclosed.Type: ApplicationFiled: June 13, 2008Publication date: September 23, 2010Applicant: FMC CORPORATIONInventors: Jan Engelsen Brinchmann, Katrine Bjornebek Fronsdal, Jan Egil Melvik
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Patent number: 7790699Abstract: Kits and compositions for producing an alginate gel are disclosed. The kits and compositions comprise soluble alginate and insoluble alginate/gelling ion particles. Methods for dispensing a self-gelling alginate dispersion are disclosed. The methods comprise forming a dispersion of insoluble alginate/gelling ion particles in a solution containing soluble alginate, and dispensing the dispersion whereby the dispersion forms an alginate gel matrix. The methods may include dispensing the dispersion into the body of an individual. An alginate gel having a thickness of greater than 5 mm and a homogenous alginate matrix network and homogenous alginate gels free of one or more of: sulfates citrates, phosphates, lactatates, EDTA or lipids are disclosed. Implantable devices comprising a homogenous alginate gel coating are disclosed. Methods of improving the viability of pancreatic islets, or other cellular aggregates or tissue, following isolation and during storage and transport are disclosed.Type: GrantFiled: October 12, 2005Date of Patent: September 7, 2010Assignee: FMC Biopolymer ASInventors: Jan-Egil Melvik, Michael Dornish, Edvar Onsoyen, Astrid B. Berge, Terje Svendsen
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Patent number: 7790193Abstract: Methods of inhibiting proliferation of a plurality of proliferating cells are disclosed. Methods of inhibiting cell overgrowth on compositions that are in an animal's body are disclosed. Methods of inhibiting cell overgrowth on a device that is in an animal's body are disclosed. Devices that have on their exterior surface an alginate matrix that comprises Strontium are disclosed. Compositions comprising an alginate body and alginate sheets that each comprise a single layer of cells coating the exterior surface of the alginate body are disclosed. Methods of preparing an artificial tissue are disclosed. Devices comprising cells encapsulated within an alginate matrix and/or maintained as a monolayer on an alginate body, and methods of making and using the same are disclosed. Methods of coating compositions and devices are disclosed.Type: GrantFiled: December 23, 2004Date of Patent: September 7, 2010Assignee: FMC Biopolymer ASInventors: Jan Egil Melvik, Michael Dornish
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Alginate Coated, Polysaccharide Gel-Containing Foam Composite, Preparative Methods, and Uses Thereof
Publication number: 20090010983Abstract: The invention relates to composites comprising a polysaccharide gelled within pores of a foam and an polysaccharide coating, methods of preparation, and uses thereof, for example, in biomedical applications such as cell culture media and implants, controlled release delivery systems, food applications, industrial applications, and personal care applications such as cosmetic and oral hygiene.Type: ApplicationFiled: June 13, 2008Publication date: January 8, 2009Applicant: FMC CorporationInventors: Jan Egil Melvik, Therese Andersen -
Publication number: 20070248642Abstract: The invention provides a method of producing a gelled foam comprising the steps of: forming a dispersion by mixing i) a solution comprising a soluble polysaccharide and a plasticizer and adding a polysaccharide/gel-forming ion particles or ii) a soluble, preferably immediately soluble, polysaccharide, preferably an alginate, a polysaccharide/gel-forming ion particles, and adding a solvent, said dispersion (ii) further comprising a water soluble plasticizer to make the dispersion and then aerating the dispersion to form the foam. The foam may be inhomogeneous in structure which is useful in providing improved delivery of a component carried in the foam and in degradation.Type: ApplicationFiled: March 1, 2007Publication date: October 25, 2007Inventors: Michael Dornish, Therese Andersen, Jan Egil Melvik
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Publication number: 20060159823Abstract: Kits and compositions for producing an alginate gel are disclosed. The kits and compositions comprise soluble alginate and insoluble alginate/gelling ion particles. Methods for dispensing a self-gelling alginate dispersion are disclosed. The methods comprise forming a dispersion of insoluble alginate/gelling ion particles in a solution containing soluble alginate, and dispensing the dispersion whereby the dispersion forms an alginate gel matrix. The methods may include dispensing the dispersion into the body of an individual. An alginate gel having a thickness of greater than 5 mm and a homogenous alginate matrix network and homogenous alginate gels free of one or more of: sulfates citrates, phosphates, lactatates, EDTA or lipids are disclosed. Implantable devices comprising a homogenous alginate gel coating are disclosed. Methods of improving the viability of pancreatic islets, or other cellular aggregates or tissue, following isolation and during storage and transport are disclosed.Type: ApplicationFiled: October 12, 2005Publication date: July 20, 2006Inventors: Jan-Egil Melvik, Michael Dornish, Edvar Onsoyen, Astrid Berge, Terje Svendsen