Patents by Inventor Jan Endell

Jan Endell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12194095
    Abstract: The present disclosure describes a pharmaceutical combination of an anti-CD19 antibody and a phosphoinositide 3-kinase inhibitor for the treatment of non-Hodgkin's lymphoma, chronic lymphocytic leukemia and/or acute lymphoblastic leukemia.
    Type: Grant
    Filed: December 8, 2021
    Date of Patent: January 14, 2025
    Assignee: Incyte Corporation
    Inventors: Jan Endell, Mark Winderlich, Rainer Boxhammer
  • Publication number: 20240156863
    Abstract: The present invention relates to therapeutic compositions and methods for sequential treatment of cancer in human patients using therapeutic agents that bind to human CD1g.
    Type: Application
    Filed: October 30, 2020
    Publication date: May 16, 2024
    Inventors: Jan ENDELL, Stefanie FRICK
  • Publication number: 20240009196
    Abstract: The present disclsoure describes a pharmaceutical combination of an anti-CD19 antibody and a Bruton's tyrosine kinase (BTK) inhibitor and its use for the treatment of non-Hodgkin's lymphoma, chronic lymphocytic leukemia and/or acute lymphoblastic leukemia.
    Type: Application
    Filed: February 1, 2023
    Publication date: January 11, 2024
    Inventors: Jan ENDELL, Rainer BOXHAMMER, Mark WINDERLICH
  • Patent number: 11591406
    Abstract: The present disclosure relates to the treatment of multiple myeloma. Monoclonal antibody MOR202 is efficacious when administered to patient at certain dosage regimens.
    Type: Grant
    Filed: November 25, 2019
    Date of Patent: February 28, 2023
    Assignee: MORPHOSYS AG
    Inventors: Stéphane LeClair, Jan Endell, Stefan Härtle
  • Publication number: 20230014026
    Abstract: The present disclosure is directed to a combination therapy comprising an antibody or antibody fragment specific for CD19 and a polypeptide that blocks the SIRP?-CD47 innate immune checkpoint for use in the treatment of cancer, in particular hematological cancer such as leukemia or lymphoma.
    Type: Application
    Filed: June 22, 2021
    Publication date: January 19, 2023
    Inventors: Jan ENDELL, Günter FINGERLE-ROWSON, Mark Ping CHAO
  • Publication number: 20220283166
    Abstract: The present disclosure is directed to identifying characteristics and biomarkers in patients that benefit from treatment with an anti-CD19 antibody.
    Type: Application
    Filed: May 25, 2022
    Publication date: September 8, 2022
    Inventors: Jan ENDELL, Mark WINDERLICH, Rainer BOXHAMMER
  • Publication number: 20220242952
    Abstract: The present disclosure provides characteristics and biomarkers in patients that benefit from treatment with anti-CD19 antibodies (MOR00208, XmAb5574).
    Type: Application
    Filed: May 4, 2020
    Publication date: August 4, 2022
    Inventors: Christian KUFFER, Guenter FINGERLE-ROWSON, Mark WINDERLICH, Jan ENDELL
  • Publication number: 20220088197
    Abstract: The present disclosure describes a pharmaceutical combination of an anti-CD19 antibody and a phosphoinositide 3-kinase inhibitor for the treatment of non-Hodgkin's lymphoma, chronic lymphocytic leukemia and/or acute lymphoblastic leukemia.
    Type: Application
    Filed: December 8, 2021
    Publication date: March 24, 2022
    Inventors: Jan ENDELL, Mark WINDERLICH, Rainer BOXHAMMER
  • Publication number: 20220047632
    Abstract: Provided is a pharmaceutical combination comprising an antibody specific for CD19 and a natural killer cell, and a treatment method using the same. Such a pharmaceutical combination is capable of exhibiting synergistic therapeutic effects on a malignant tumor of B-cell origin such as non-Hodgkin's lymphoma, chronic lymphocytic leukemia, and/or acute lymphoblastic leukemia.
    Type: Application
    Filed: September 5, 2019
    Publication date: February 17, 2022
    Inventors: Jung Hyun HER, Mi Young JUNG, Su Hyun GWON, Ho Yong LIM, Sung Yoo CHO, Sung Yong WON, Yu Kyeong HWANG, Jan ENDELL, Rainer BOXHAMMER
  • Patent number: 11224654
    Abstract: The present disclosure describes a pharmaceutical combination of an anti-CD19 antibody and a phosphoinositide 3-kinase inhibitor for the treatment of non-Hodgkin's lymphoma, chronic lymphocytic leukemia and/or acute lymphoblastic leukemia.
    Type: Grant
    Filed: August 18, 2016
    Date of Patent: January 18, 2022
    Assignee: MORPHOSYS AG
    Inventors: Jan Endell, Mark Winderlich, Rainer Boxhammer
  • Publication number: 20210130461
    Abstract: The present disclosure is directed to a combination therapy comprising an anti-CD19 antibody or antibody fragment thereof and gamma delta T-cells (?? T-cells) for use in the treatment of leukemia or lymphoma.
    Type: Application
    Filed: October 30, 2020
    Publication date: May 6, 2021
    Inventors: Jan Endell, Rainer Boxhammer, Dominik Pretscher
  • Publication number: 20200206228
    Abstract: The present disclosure describes a pharmaceutical combination of an anti-CD19 antibody and a Bruton's tyrosine kinase (BTK) inhibitor and its use for the treatment of non-Hodgkin's lymphoma, chronic lymphocytic leukemia and/or acute lymphoblastic leukemia.
    Type: Application
    Filed: March 2, 2020
    Publication date: July 2, 2020
    Inventors: Jan ENDELL, Rainer BOXHAMMER, Mark WINDERLICH
  • Patent number: 10617691
    Abstract: The present disclosure describes a pharmaceutical combination of an anti-CD19 antibody and a Bruton's tyrosine kinase (BTK) inhibitor for the treatment of non-Hodgkin's lymphoma, chronic lymphocytic leukemia and/or acute lymphoblastic leukemia.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: April 14, 2020
    Assignee: MORPHOSYS AG
    Inventors: Jan Endell, Rainer Boxhammer, Mark Winderlich
  • Publication number: 20200079871
    Abstract: The present disclosure relates to the treatment of multiple myeloma. Monoclonal antibody MOR202 is efficacious when administered to patient at certain dosage regimens.
    Type: Application
    Filed: November 25, 2019
    Publication date: March 12, 2020
    Inventors: Stéphane LeClair, Jan Endell, Stefan Härtle
  • Patent number: 10533057
    Abstract: The present disclosure relates to the treatment of multiple myeloma. Monoclonal antibody MOR202 is efficacious when administered to patient at certain dosage regimens.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: January 14, 2020
    Assignee: MORPHOSYS AG
    Inventors: Stéphane LeClair, Jan Endell, Stefan Härtle
  • Publication number: 20190241656
    Abstract: The present disclosure describes a pharmaceutical combination of an anti-CD19 antibody and a BCL-2 inhibitor for the treatment of non-Hodgkin's lymphoma, chronic lymphocytic leukemia and/or acute lymphoblastic leukemia.
    Type: Application
    Filed: October 27, 2017
    Publication date: August 8, 2019
    Inventors: Jan Endell, Konstantin Petropoulos, Peter Kelemen, Ranier Boxhammer, Markus Rückert
  • Publication number: 20190195879
    Abstract: The present disclosure is directed to a method of identifying a subject having chronic lymphocytic leukemia (CLL), non-Hodgkin's lymphoma (NHL), small lymphocytic lymphoma (SLL) or acute lymphoblastic leukemia (ALL) that is responsive to treatment with an anti-CD19 antibody, said method comprising: a) providing a blood sample obtained from said subject prior to treatment with said anti-CD19 antibody, b) determining the level of at least one biomarker in said sample selected from the group consisting of: i) peripheral NK cell count, and ii) CD16 expression levels on peripheral NK cells, c) comparing the level of said at least one biomarker in said sample to a predetermined cut off level, wherein levels of said at least one biomarker at or above the predetermined cut off level is indicative of a subject who would benefit from treatment with an anti-CD19 antibody.
    Type: Application
    Filed: May 30, 2017
    Publication date: June 27, 2019
    Inventors: Jan Endell, Mark Winderlich, Rainer Boxhammer
  • Patent number: 10308722
    Abstract: The present disclosure is directed to a method of treating multiple myeloma or non-hodgkins lymphoma with a pharmaceutical composition comprising an anti-CD38 antibody in combination with thalidomide, lenalidomide, or pomalidomide.
    Type: Grant
    Filed: August 7, 2017
    Date of Patent: June 4, 2019
    Assignee: MORPHOSYS AG
    Inventors: Lisa Rojkjaer, Rainer Boxhammer, Jan Endell, Mark Winderlich, Christofer Samuelsson
  • Publication number: 20190048091
    Abstract: The present disclosure relates to the treatment of multiple myeloma. Monoclonal antibody MOR202 is efficacious when administered to patient at certain dosage regimens.
    Type: Application
    Filed: May 13, 2016
    Publication date: February 14, 2019
    Inventors: Stéphane LeClair, Jan Endell, Stefan Härtle
  • Publication number: 20180228893
    Abstract: The present disclosure describes a pharmaceutical combination of an anti-CD19 antibody and a phosphoinositide 3-kinase inhibitor for the treatment of non-Hodgkin's lymphoma, chronic lymphocytic leukemia and/or acute lymphoblastic leukemia.
    Type: Application
    Filed: August 18, 2016
    Publication date: August 16, 2018
    Inventors: Jan Endell, Mark Winderlich, Rainer Boxhammer