Patents by Inventor Jan Enghild

Jan Enghild has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of detecting Alzheimer's disease
    Patent number: 6027896
    Abstract: Methods of diagnosing or prognosing Alzheimer's disease in a subject are disclosed. The methods involve directly or indirectly detecting the presence or absence of an apolipoprotein E type 4 (ApoE4) isoform or DNA encoding ApoE4 in the subject. The presence of ApoE4 indicates the subject is afflicted with Alzheimer's disease or at risk of developing Alzheimer's disease. A novel immunochemical assay for detecting the presence or absence of the Apoliprotein E (ApoE) E4 allele in a subject is also disclosed.
    Type: Grant
    Filed: April 15, 1998
    Date of Patent: February 22, 2000
    Assignee: Duke University
    Inventors: Allen D. Roses, Warren J. Strittmatter, Guy S. Salvesen, Jan Enghild, Donald E. Schmechel
  • Apolipoprotein E isoform-specific monoclonal antibodies
    Patent number: 5767248
    Abstract: Methods of diagnosing or prognosing Alzheimer's disease in a subject are disclosed. The methods involve directly or indirectly detecting the presence or absence of an apolipoprotein E type 4 (ApoE4) isoform or DNA encoding ApoE4 in the subject. The presence of ApoE4 indicates the subject is afflicted with Alzheimer's disease or at risk of developing Alzheimer's disease. A novel immunochemical assay for detecting the presence or absence of the Apoliprotein E (ApoE) E4 allele in a subject is also disclosed.
    Type: Grant
    Filed: April 8, 1997
    Date of Patent: June 16, 1998
    Assignee: Duke University
    Inventors: Allen D. Roses, Warren J. Strittmatter, Guy S. Salvesen, Jan Enghild, Donald E. Schmechel
  • Method to screen compounds that affect GAPDH binding to polyglutamine
    Patent number: 5723301
    Abstract: GAPDH binds to expanded polyglutamine regions which are found in proteins encoded by genes with CAG repeat domains, which genes cause inherited neurodegenerative disorders and are associated with certain psychiatric disorders. Therapeutic methods are based on inhibiting the binding of GAPDH to expanded polyglutamine regions. A method of screening compounds for the ability to inhibit binding of GAPDH to polyglutamine regions is described.
    Type: Grant
    Filed: November 3, 1995
    Date of Patent: March 3, 1998
    Assignee: Duke University
    Inventors: James R. Burke, Jeffery M. Vance, Jan Enghild, Warren J. Strittmatter
  • Kit for detecting the ApoE4 allele, and for diagnosing the existence or risk of developing Alzheimer's disease
    Patent number: 5716828
    Abstract: Methods of diagnosing or prognosing Alzheimer's disease in a subject are disclosed. The methods involve directly or indirectly detecting the presence or absence of an apolipoprotein E type 4 (ApoE4) isoform or DNA encoding ApoE4 in the subject. The presence of ApoE4 indicates the subject is at risk of developing Alzheimer's disease. A novel immunochemical assay for detecting the presence or absence of the Apoliprotein E (ApoE) E4 allele in a subject is also disclosed.
    Type: Grant
    Filed: May 15, 1995
    Date of Patent: February 10, 1998
    Assignee: Duke University
    Inventors: Allen D. Roses, Warren J. Strittmatter, Guy S. Salvesen, Jan Enghild, Donald E. Schmechel
  • Methods of screening for Alzheimer's disease
    Patent number: 5508167
    Abstract: Methods of diagnosing or prognosing Alzheimer's disease in a subject are disclosed. The methods involve directly or indirectly detecting the presence or absence of an apolipoprotein E type 4 (ApoE4) isoform or DNA, encoding ApoE4 in the subject. The presence of ApoE4 indicates the subject is afflicted with Alzheimer's disease or at risk of developing Alzheimer's disease. A novel immunochemical assay for detecting the presence or absence of the Apoliprotein E (ApoE) E4 allele in a subject is also disclosed.
    Type: Grant
    Filed: April 13, 1994
    Date of Patent: April 16, 1996
    Assignee: Duke University
    Inventors: Allen D. Roses, Warren J. Strittmatter, Guy S. Salvesen, Jan Enghild, Donald E. Schmechel