Patents by Inventor Jan-Erik Nyström

Jan-Erik Nyström has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prodrugs of thrombin inhibitors
    Patent number: 7354905
    Abstract: There is provided compounds of formula I, R1O(O)C—CH2—(R)Cgl-Aze-Pab-R2I wherein R1 and R2 have meanings given in the description, which are useful as prodrugs of inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (eg thrombosis) or as anticoagulants.
    Type: Grant
    Filed: February 12, 2004
    Date of Patent: April 8, 2008
    Assignee: AstraZeneca AB
    Inventors: Thomas Antonsson, David Gustafsson, Kurt-Jürgen Hoffmann, Jan-Erik Nyström, Henrik Sörensen, Mikael Sellén
  • Amidino derivatives and their use as thrombin inhibitors
    Patent number: 7241757
    Abstract: There is provided compounds of formula I wherein R1, Rx, Y, Ry, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
    Type: Grant
    Filed: April 2, 2004
    Date of Patent: July 10, 2007
    Assignee: AstraZeneca AB
    Inventors: Tord Inghardt, Olle Karlsson, Marcel Linschoten, Jan-Erik Nyström
  • Amino acid derivatives
    Patent number: 6921758
    Abstract: There is provided amino acid derivatives of formula I, wherein p, q, R1, R2, R3, R4, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
    Type: Grant
    Filed: June 26, 2003
    Date of Patent: July 26, 2005
    Assignee: AstraZeneca AB
    Inventors: David Gustafsson, Jan-Erik Nyström
  • Amino acid derivatives and their use as thrombin inhibitors
    Patent number: 6838478
    Abstract: There is provided compounds of formula I, wherein R1, R2, R3, Rx, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
    Type: Grant
    Filed: April 30, 2001
    Date of Patent: January 4, 2005
    Assignee: AstraZeneca AB
    Inventors: David Gustafsson, Jan-Erik Nyström
  • Amidino derivatives and their use as thrombin inhibitors
    Patent number: 6750243
    Abstract: There is provided compounds of formula I wherein R1, Rx, Y, Ry, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
    Type: Grant
    Filed: March 21, 2000
    Date of Patent: June 15, 2004
    Assignee: AstraZeneća AB
    Inventors: Tord Inghardt, Olle Karlsson, Marcel Linschoten, Jan-Erik Nyström
  • Thiochromane derivatives and their use as thrombin inhibitors
    Patent number: 6716834
    Abstract: There is provided compounds of formulae I and IA wherein Y, R1, R2, R3, D1 and D2 have meanings given in the description which are useful as, or as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
    Type: Grant
    Filed: November 12, 2002
    Date of Patent: April 6, 2004
    Assignee: AstraZeneca AB
    Inventors: Kjell Andersson, Tord Inghardt, Olle Karlsson, Marcel Linschoten, Jan-Erik Nyström, Gunnel Sundén
  • Amino acid derivatives
    Patent number: 6617320
    Abstract: There is provided amino acid derivatives of formula I, wherein p, q, R1, R2, R3, R4, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as hirombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
    Type: Grant
    Filed: November 29, 2001
    Date of Patent: September 9, 2003
    Assignee: AstraZeneca AB
    Inventors: David Gustafsson, Jan-Erik Nyström
  • Amidinobenzylamine derivatives and their use as thrombin inhibitors
    Patent number: 6599894
    Abstract: There is provided compounds of formula I wherein R1, R2, Y, R3 and R4 have meanings given in the description which are useful as, or as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
    Type: Grant
    Filed: March 16, 2000
    Date of Patent: July 29, 2003
    Assignee: AstŕaZeneca AB
    Inventors: Tord Inghardt, Jan-Erik Nyström
  • Amidino derivatives and their use as thrombin inhibitors
    Patent number: 6576657
    Abstract: There is provided compounds of formula I, wherein R1, Rx, Y, Ry, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
    Type: Grant
    Filed: April 30, 2001
    Date of Patent: June 10, 2003
    Assignee: AstraZeneca AB
    Inventors: Olle Karlsson, Marcel Linschoten, Jan-Erik Nyström
  • Amino acid derivatives
    Patent number: 6337343
    Abstract: There is provided amino acid derivatives of formula I, wherein p, q, R1, R2, R3, R4, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
    Type: Grant
    Filed: March 29, 2000
    Date of Patent: January 8, 2002
    Assignee: AstraZeneca AB
    Inventors: David Gustafsson, Jan-Erik Nyström
  • Compounds
    Patent number: 6337394
    Abstract: There is provided compounds of formula I, wherein R1, R2, R3, Rx, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
    Type: Grant
    Filed: December 29, 1998
    Date of Patent: January 8, 2002
    Assignee: AstraZeneca AB
    Inventors: Olle Karlsson, Marcel Linschoten, Jan-Erik Nyström
  • Amidino derivatives and their use as thrombin inhibitors
    Patent number: 6265397
    Abstract: There is provided compounds of formula I, wherein R1, Rx, Y, Ry, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
    Type: Grant
    Filed: June 26, 1998
    Date of Patent: July 24, 2001
    Assignee: AstraZeneca AB
    Inventors: Olle Karlsson, Marcel Linschoten, Jan-Erik Nyström
  • Prodrugs of thrombin inhibitors
    Patent number: 6262028
    Abstract: There is provided compounds of formula I, R1O(O)C—CH2—(R)Cgl—Aze—Pab—R  I wherein R1 and R2 have meanings given in the description, which are useful as prodrugs of inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (eg thrombosis) or as anticoagulants.
    Type: Grant
    Filed: July 15, 1999
    Date of Patent: July 17, 2001
    Assignee: AstraZeneca AB
    Inventors: Thomas Antonsson, David Gustafsson, Kurt-Jürgen Hoffmann, Jan-Erik Nyström, Henrik Sörensen, Mikael Sellén
  • Amino acid derivatives and their use as thrombin inhibitors
    Patent number: 6255301
    Abstract: There is provided compounds of formula I, wherein R1, R2, R3, Rx, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required as in thrombosis or as anticoagulants.
    Type: Grant
    Filed: July 14, 1997
    Date of Patent: July 3, 2001
    Assignee: AstraZeneca AB
    Inventors: David Gustafsson, Jan-Erik Nyström