Patents by Inventor Jan H. van Maarseveen

Jan H. van Maarseveen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diazabicyclo alkane derivatives with NKantagonistic activity
    Patent number: 7202238
    Abstract: The present invention relates to a group of unique diazabicyclo alkane derivatives having interesting neurokinin-NK1 receptor antagonistic activity represented by the general formula (1) wherein: R1 represents phenyl, 2-indolyl, 3-indolyl, 3-indazolyl or benzo[b]thiophen-3-yl, which groups may be substituted with halogen or alkyl (1–3C), R2 and R3 independently represent halogen, H, OCH3, CH3 and CF3, R4, R5 and R6 independently represent H, OH, O-alkyl(1–4C), CH2OH, NH2, dialkyl(1–3C)N, pyrrolidin-1-yl, piperidin-1-yl, morpholin-4-yl or morpholin-4-yl substituted with one or two methyl or methoxymethyl groups, morpholin-4-ylamino, morpholin-4-ylmethyl, imidazol-1-yl, thiomorpholin-4-yl, 1,1-dioxothiomorpholin-4-yl or 3-oxa-8-azabicyclo[3.2.
    Type: Grant
    Filed: April 2, 2003
    Date of Patent: April 10, 2007
    Assignee: Solvay Pharmaceuticals B.V.
    Inventors: Dirk de Boer, Hein K. A. C. Coolen, Mayke B. Hesselink, Wouter I. Iwema Bakker, Gijsbert D. Kuil, Jan H. van Maarseveen, Andrew C. McCreary, Gustaaf J. M. van Scharrenburg
  • Piperazine oxime dervatives having NK-1 receptor antagonistic activity
    Patent number: 7094779
    Abstract: The present invention relates to a group of novel piperazine oxime derivatives having interesting NK-1 antagonistic activity.
    Type: Grant
    Filed: July 3, 2002
    Date of Patent: August 22, 2006
    Assignee: Solvay Pharmaceuticals B.V.
    Inventors: Wouter I. Iwema Bakker, Jan H. van Maarseveen, Hein K. A. C. Coolen, Martinus Th. M. Tulp, Arnoldus H. J. Herremans, Andrew C. Mccreary, Gustaaf J. M. van Scharrenburg, Adrianus van den Hoogenband
  • Piperazine oxime dervatives having nk-1 receptor antagonistic activity
    Publication number: 20040176389
    Abstract: The present invention relates to a group of novel piperazine oxime derivatives having interesting NK-1 antagonistic activity.
    Type: Application
    Filed: December 12, 2003
    Publication date: September 9, 2004
    Inventors: Wouter I Ivema Bakker, Jan H van Maarseveen, Hein K A C Coolen, Martinus Th M Tulp, Arnoldus H J Herremans, Andrew C Mccreary, Gustaaf J M van Scharrenburg, Adrianus van den Hoogenband
  • Piperazinophenyl- and piperazinophenyloxycarboxylic acid derivatives, and processes and intermediates for their preparation and pharmaceutical compositions comprising them
    Patent number: 5843948
    Abstract: Compounds having fibrinogen receptor-antagonistic activity, of the general formula I ##STR1## in which Z is oxygen or a methylene group,B is a phenyl or pyridyl radical,R.sup.1 is hydrogen or a group forming a biolabile ester, and their physiologically acceptable acid addition salts and physiologically acceptable salts of acids of formula I.
    Type: Grant
    Filed: December 19, 1997
    Date of Patent: December 1, 1998
    Assignee: Solvay Pharmaceuticals GmbH
    Inventors: Wolfgang Kehrbach, Uwe Schoen, Jack A. J. den Hartog, Jan H. van Maarseveen, Chris G. Kruse, Jochen Antel, Jan-Hendrik Reinders, Dieter Ziegler, Gerhard-Wilhelm Bielenberg
  • Method of preparing N-oxo-tetrahydro-.beta.-carbolines
    Patent number: 5348949
    Abstract: The invention relates to a method of preparing N-oxo-tetrahydro-.beta.-carbolines having formula 1. ##STR1## by an intramolecular ringclosure reaction of compounds of formula 2. ##STR2## wherein Z is an aldehyde function or acetal function, or is a functional group which can be converted into such a function during the ringclosure reaction.The eudistomin derivatives within the group of compounds having formula 1 have strong antiviral and antitumour activity.
    Type: Grant
    Filed: February 12, 1993
    Date of Patent: September 20, 1994
    Assignee: Duphar International Research B.V.
    Inventors: Peter H. H. Hermkens, Jan H. Van Maarseveen, Johan W. Scheeren, Cornelis G. Kruse
  • Method of preparing n-oxo-tetrahydro-beta-carbolines
    Patent number: 5106840
    Abstract: The invention relates to a method of preparing N-oxo-tetrahydro-.beta.-carbolines having formula 1. ##STR1## wherein R.sub.1 is lower alkyl or alkoxy, halogen, trifluoromethyl, lower alkylthio, hydroxy, amino, lower mono- or dialkyl- or acylamino.n has the value 0, 1 or 2,R.sub.2 is hydrogen, lower alkyl or acyl,R.sub.3 is hydrogen, lower alkyl or alkoxycarbonyl, or a phenyl group optionally substituted with a group R.sub.
    Type: Grant
    Filed: June 5, 1990
    Date of Patent: April 21, 1992
    Assignee: Duphar International Research B.V.
    Inventors: Peter H. H. Hermkens, Jan H. Van Maarseveen, Johan W. Scheeren, Cornelis G. Kruse