Abstract: The present disclosure provides an apparatus for dispensing fluid from a reagent container having a pump comprising a control and an outlet whereby moving the control causes fluid to flow from the outlet. The apparatus comprises a pump actuator assembly comprising a first bracket configured to be mounted on the reagent container, a second bracket configured to engage the control, and a pump actuator connected to move the second bracket relative to the first bracket; a dispenser assembly comprising a dispensing nozzle, a nozzle positioning mechanism configured to move the dispensing nozzle through a plurality of positions, and a flexible tube having a first end connected to the dispensing nozzle and a second end connectible to the outlet of the pump; and a controller in communication with the dispenser assembly and the pump actuator assembly for controlling the pump actuator and the nozzle positioning mechanism.

Abstract: The present invention relates to a process for ion irradiation of a particulate substrate containing the steps of embedding particulate substrate in a solid matrix having 10B atoms, and exposing the matrix obtained in the previous step to a neutron flux to give irradiated particulate substrate. The process is extremely effective and amenable to large scale and is particularly suitable for producing irradiated nanodiamonds and irradiated SiC particles.

Abstract: Nanodiamonds having a positive ?-potential of at least 1 mV for use in sequestration of at least one FGF family member in organisms in vivo and in vitro. It has been found that nanodiamonds with a positive ?-potential show an extremely strong and selective binding to FGF family members, thus leading to their usability in the treatment of diseases related to aberrant FGF-FGFR signalling and/or interaction.

Abstract: The present invention relates to a process for ion irradiation of a particulate substrate containing the steps of embedding particulate substrate in a solid matrix having 10B atoms, and exposing the matrix obtained in the previous step to a neutron flux to give irradiated particulate substrate. The process is extremely effective and amenable to large scale and is particularly suitable for producing irradiated nanodiamonds and irradiated SiC particles.

Abstract: Nanodiamonds having a positive ?-potential of at least 1 mV for use in sequestration of at least one FGF family member in organisms in vivo and in vitro. It has been found that nanodiamonds with a positive ?-potential show an extremely strong and selective binding to FGF family members, thus leading to their usability in the treatment of diseases related to aberrant FGF-FGFR signalling and/or interaction.