Patents by Inventor Jan-Heiner Kupper
Jan-Heiner Kupper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240109028Abstract: The invention relates to a device and to a method for sequestering atmospheric carbon dioxide using at least one air capture module in conjunction with a bioreactor equipped with an autotrophic microorganisms.Type: ApplicationFiled: April 3, 2023Publication date: April 4, 2024Applicant: UB - ONE STIFTUNGS GMBHInventor: Jan-Heiner Küpper
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Publication number: 20210093998Abstract: The invention relates to a device and to a method for sequestering atmospheric carbon dioxide using at least one air capture module in conjunction with a bioreactor equipped with an autotrophic microorganisms.Type: ApplicationFiled: November 5, 2018Publication date: April 1, 2021Applicant: ONE STIFTUNGS GMBHInventor: Jan-Heiner KÜPPER
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Patent number: 10036052Abstract: This invention relates to a biogenic substance production process wherein a) at least one starting material has b) at least one enzyme added to it and the product resulting from b) has c) at least one liver cell added to it, and d) at least one biogenic substance is isolated.Type: GrantFiled: November 11, 2014Date of Patent: July 31, 2018Assignee: Brandenburgische Technische Universität Cottbus-SenftenbergInventors: Katrin Scheibner, Jan-Heiner Küpper, Kai-Uwe Schmidtke, Sebastian Miethbauer, Natalie Herzog
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Publication number: 20160289724Abstract: This invention relates to a biogenic substance production process wherein a) at least one starting material has b) at least one enzyme added to it and the product resulting from b) has c) at least one liver cell added to it, and d) at least one biogenic substance is isolated.Type: ApplicationFiled: November 11, 2014Publication date: October 6, 2016Inventors: Katrin SCHEIBNER, Jan-Heiner KÜPPER, Kai-Uwe SCHMIDTKE, Sebastian MIETHBAUER, Natalie HERZOG
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Publication number: 20140186311Abstract: The invention relates to a method for transiently immortalizing cells according to which immortalization proteins are introduced into the cells from outside. The invention also relates to a method for producing cells according to which organ-related cells are transiently immortalized by the exogenous supply of immortalization proteins and are remortalized after their expansion. The invention further relates to the cells produced according to the inventive method, to the use of said cells for producing a transplant and to the immortalization proteins used in the method.Type: ApplicationFiled: January 21, 2014Publication date: July 3, 2014Applicant: HEART BIOSYSTEMS GMBHInventors: Jan-Heiner Kupper, Ralph Meyer, Mirella Meyer-Ficca, Anne Kuhn
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Publication number: 20140087470Abstract: A gene complex for reversibly immortalizing cells contains an immortalizing gene region, which possesses at least a resistance gene, an immortalizing gene and, preferably, a suicide gene, and also two sequences which flank the gene region and which function as recognition sites for homologous intramolecular recombination, and at least one promoter located upstream of the gene region. A gene complex for imnomodulating cells contains a first immunomodulating gene region, whose expression inhibits the function of MHC I molecules, a second immunomodulating gene region, whose expression leads to the inactivation of natural killer cells, and a resistance gene. A method for obtaining cells involves preparing organ-related cells which are immortalized by transferring the first gene complex and immunomodulated by transferring the second gene complex. After the immortalized cells have been expanded, the immortalization is reversed.Type: ApplicationFiled: November 4, 2013Publication date: March 27, 2014Applicant: Heart Biosystems GmbHInventors: JAN-HEINER KUPPER, REINHARD KANDOLF, ANNE KUHN
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Publication number: 20130323721Abstract: The invention relates to a method for carrying out genotoxicity tests of chemical, biological and physical active substances or agents with the aid of cell culture systems of proliferating physiologically active liver cells.Type: ApplicationFiled: October 4, 2011Publication date: December 5, 2013Applicant: MEDICYTE GMBHInventors: Adrianus J.C.M. Braspenning, Stefan Heinz, Astrid Nörenberg, Nicola Hewitt, Jan-Heiner Küpper
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Publication number: 20130035287Abstract: The invention relates to a method for transiently immortalizing cells according to which immortalization proteins are introduced into the cells from outside. The invention also relates to a method for producing cells according to which organ-related cells are transiently immortalized by the exogenous supply of immortalization proteins and are remortalized after their expansion. The invention further relates to the cells produced according to the inventive method, to the use of said cells for producing a transplant and to the immortalization proteins used in the method.Type: ApplicationFiled: June 22, 2012Publication date: February 7, 2013Applicant: HEART BIOSYSTEMS GMBHInventors: Jan-Heiner Kupper, Ralph Meyer, Mirella Meyer-Ficca, Anne Kuhn
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Publication number: 20100047218Abstract: A gene complex for reversibly immortalizing cells contains an immortalizing gene region, which possesses at least a resistance gene, an immortalizing gene and, preferably, a suicide gene, and also two sequences which flank the gene region and which function as recognition sites for homologous intramolecular recombination, and at least one promoter located upstream of the gene region. A gene complex for immunomodulating cells contains a first immunomodulating gene region, whose expression inhibits the function of MHC I molecules, a second immunomodulating gene region, whose expression leads to the inactivation of natural killer cells, and a resistance gene. A method for obtaining cells involves preparing organ-related cells which are immortalized by transferring the first gene complex and immunomodulated by transferring the second gene complex. After the immortalized cells have been expanded, the immortalization is reversed.Type: ApplicationFiled: November 3, 2009Publication date: February 25, 2010Applicant: HEART BIOSYSTEMS GMBHInventors: JAN-HEINER KUPPER, REINHARD KANDOLF, ANNE KUHN
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Publication number: 20070237754Abstract: The invention relates to a method for transiently immortalizing cells according to which immortalization proteins are introduced into the cells from outside. The invention also relates to a method for producing cells according to which organ-related cells are transiently immortalized by the exogenous supply of immortalization proteins and are remortalized after their expansion. The invention further relates to the cells produced according to the inventive method, to the use of said cells for producing a transplant and to the immortalization proteins used in the method.Type: ApplicationFiled: May 21, 2007Publication date: October 11, 2007Inventors: Jan-Heiner Kupper, Ralph Meyer, Mirella Meyer-Ficca, Anne Kuhn
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Publication number: 20050244969Abstract: The invention relates to a method for transiently immortalizing cells in which immortalizing proteins are introduced into the cells from the exterior, and to a method for obtaining cells in which organ-related cells are transiently immortalized by supplying immortalizing proteins externally and are remortalized after expansion. The invention furthermore relates to cells which are prepared by these methods, to the use of the cells for preparing a transplant and to immortalizing proteins which are to be used in the methods.Type: ApplicationFiled: October 7, 2002Publication date: November 3, 2005Inventors: Jan-Heiner Kupper, Ralph Meyer, Mirella Meyer-Ficca, Anne Kuhn
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Patent number: 6936595Abstract: The invention relates to a vector for the gene therapeutic treatment of tumours, especially in connection with radiotherapy. Said vector is provided with a therapeutic gene in the DNA sequence thereof. The gene is controlled by the promoter for the catalytic subunit of the telomerase or by the promoter for cyclin A.Type: GrantFiled: April 2, 2002Date of Patent: August 30, 2005Assignee: Heart BioSystems, GmbHInventors: Jan-Heiner Küpper, Ralph Meyer, Mirella Meyer-Ficca, Reinhard Kandolf
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Publication number: 20030161819Abstract: A gene complex for reversibly immortalizing cells contains an immortalizing gene region, which possesses at least a resistance gene, an immortalizing gene and, preferably, a suicide gene, and also two sequences which flank the gene region and which function as recognition sites for homologous intramolecular recombination, and at least one promoter located upstream of the gene region (FIG. 1). A gene complex for immunomodulating cells contains a first immunomodulating gene region, whose expression inhibits the function of MHC I molecules, a second immunomodulating gene region, whose expression leads to the inactivation of natural killer cells, and a resistance gene. A method for obtaining cells involves preparing organ-related cells which are immortalized by transferring the first gene complex and immunomodulated by transferring the second gene complex. After the immortalized cells have been expanded, the immortalization is reversed.Type: ApplicationFiled: March 11, 2003Publication date: August 28, 2003Inventors: Jan-Heiner Kupper, Reinhard Kandolf, Anne Kuhn
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Publication number: 20030044385Abstract: The invention relates to a vector for the gene therapeutic treatment of tumours, especially in connection with radiotherapy. Said vector is provided with a therapeutic gene in the DNA sequence thereof. The gene is controlled by the promoter for the catalytic subunit of the telomerase or by the promoter for cyclin A.Type: ApplicationFiled: April 2, 2002Publication date: March 6, 2003Inventors: Jan-Heiner Kupper, Ralph Meyer, Mirella Meyer-Ficca, Reinhard Kandolf
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Patent number: 5952169Abstract: The present invention relates to a DNA construct containing a cDNA sequence for human poly(ADP-ribose)-polymerase, cell lines containing the DNA construct, and a process for identifying DNA-damaging substances by means of these cell lines which overexpress poly(ADP-ribose)-polymerase.Type: GrantFiled: July 24, 1996Date of Patent: September 14, 1999Assignee: Deutsches Krebsforschungzentrum Stiftung des Offentlichen Rechts Im Neuenheimer Feld 280Inventors: Alexander Burkle, Leon Van Gool, Jan-Heiner Kupper, Harald Zur Hausen