Abstract: A multi-source illumination apparatus for illuminating a sample with charged particles, wherein beams, from a plurality of sources, are arranged such that a beam from at least one source intersects, at a plane of a condenser lens, with at least part of one other beam from a different one of the plurality of sources. The condenser lens is configured to separately collimate the received beams from each source. A manipulator array arrangement is configured to manipulate the collimated beams to generate one or more beams, in a single column, that include charged particles from the plurality of sources. The manipulator array arrangement includes a multi-beam generator configured to receive the plurality of substantially parallel substantially collimated beams generated by the deflector array, and generate a multibeam in dependence on the received plurality of substantially parallel substantially collimated beams, wherein the multi-beam includes a plurality of substantially collimated sub-beams.

Abstract: A stage apparatus including: an object table configured to hold an object; a positioning device configured to position the object table and the object held by the object table; and a remote temperature sensor configured to measure a temperature of the object table and/or the object, wherein the remote temperature sensor comprises a passive temperature sensing element.

Abstract: A lateral flow test device and method for using same are provided. The device includes epitope test regions having a fragment of an antigenic protein and a full length antigenic protein, and a receptor test region having a receptor for the antigenic protein. Test samples are added to a conjugate pad including free labelled antigenic protein fragments. Neutralising antibodies in the test sample bind to the free labelled antigenic protein, and are detected by the test regions. Binding kinetics and other characteristics of the antibodies can be investigated by monitoring development of label at the test regions, and comparing the same at different test regions. Embodiments describe use for determining antibodies to SARS-COV-2, using RBD fragments, spike proteins, and human ACE2 receptors, at the respective test regions.

Abstract: Process for the preparation of a powder comprising bio active molecules, said process comprising the steps of (i) providing a liquid composition comprising bio active molecules, (ii) optionally pre-heating said liquid composition, provided that the temperature of the liquid composition does not exceed 65° C., (iii) transporting the optionally pre-heated liquid composition to the top of a spray drying tower via a tower feeding line, (iv) raising the temperature of the optionally pre-heated liquid composition using a direct electric volumetric heater located within the tower feeding line, the final temperature of the liquid composition being in the range 60-90° C., followed by (v) transporting the resulting liquid composition via the tower feeding line to the atomizer of a spray-dryer.

Abstract: The present invention is related to a cartridge. More in particular, the present invention relates to a cartridge by which a liquid held in the cartridge can be mixed, within the cartridge, with a further liquid held in the cartridge or with a pressurized gas. The present invention further relates to a cartridge system comprising such a cartridge and a device in which the cartridge can be releasably inserted, wherein the device is configured for providing pressurized gas(ses) to be used as propellant(s) for moving the liquid(s) inside the cartridge for the purpose of mixing the liquid(s), and/or to be used as gas to be mixed.

Abstract: The invention relates to methods for preparing a compound comprising a peptide attached to a molecular scaffold whereby multiple peptide loops are formed, to compounds that can be obtained with such methods and uses thereof.

Abstract: The invention relates to methods for preparing a compound comprising a peptide attached to a molecular scaffold whereby multiple peptide loops are formed, to compounds that can be obtained with such methods and uses thereof.

Abstract: The invention relates to methods for preparing a compound comprising a peptide attached to a molecular scaffold whereby multiple peptide loops are formed, to compounds that can be obtained with such methods and uses thereof.

Abstract: The present invention relates to a method for improving protein yield. The method comprises modifying the value of a set of relevant protein features to fall within an optimal range or to become more close to an optimal value for one or more protein features in the eukaryotic host.

Abstract: The invention relates to an elongate membrane assembly having a length, a width and a height, the assembly comprising a microporous membrane layer supported on a liquid-impermeable support layer and the assembly being suitable for lateral flow of a liquid through the membrane layer under the action of capillary forces, wherein the assembly has a constant height and at least part of the membrane layer has a first thickness in the range of from 20 to 80 ?m over the entire width of the assembly. The invention further relates to a lateral flow immunoassay device comprising such membrane assembly.

Abstract: A thermostat for a HVAC comprising: a data communication port for connection to the HVAC, wherein the thermostat is arranged to communicate via the data communication port an operating parameter of the HVAC, and estimate an energy consumption of the HVAC from the communicated operating parameter of the HVAC. The operating parameter may express a fraction of a nominal load of the HVAC, the thermostat being arranged to estimate the energy consumption from a multiplication of the operating parameter and a nominal energy consumption parameter of the HVAC at the nominal load.

Abstract: A stream of multicast messages is forwarded through a network to a plurality of subscriber devices (18). The stream is inverse multiplexed and transmitted distributed over a plurality of communication channels (14). A plurality of inverse demultiplexers (16) is provided, to reassemble a plurality of copies of the stream from the multiplexed streams from the communication channels at different locations. Preferably, the final communication channels to a plurality of subscribers (e.g. telephone lines to different homes) are used as communication channels for said inverse multiplexing and the inversely multiplexed data is communicated locally (17) between the subscribers to enable reassembly of copies of the stream.

Abstract: Method for dispensing a foamed product, wherein gas is supplied to the product via a microfiltration device, includes a product dispensing system, provided with a holder which contains a product to be dispensed, and a product discharge arrangement for discharging product coming from the holder. The product discharge arrangement is provided with a microfiltration device which is connectable to a fluid supply for supplying gas to the product during product discharge.

Abstract: The present invention relates to a method for improving protein yield. The method comprises modifying the value of a set of relevant protein features to fall within an optimal range or to become more close to an optimal value for one or more protein features in the eukaryotic host.

Abstract: Described are mixtures of at least four of the alkadienamides defined according to the structure: wherein R represents C1-C2 n-alkyl; R1 is 2-methyl-1-propyl and R2 is hydrogen, or R1 and R2 taken together is a moiety having the formula —(CH2)n— wherein n is 4 or 5, or compositions containing substantial concentrations of such mixtures, prepared according to novel processes: (a) extraction of a ground substantially dried fruit of one of the Piper species, Piper longum Linn or Piper peepuloides; (b) natural product-forming synthesis; or (c) synthetic product-forming synthesis. Also described are uses of the thus-formed products for augmenting, enhancing or imparting an aroma, taste, chemesthetic effect and/or antibacterial effect in or to a consumable material and/or in the oral cavity and/or on the mammalian epidermis.

Abstract: Described are mixtures of at least four of the alkadienamides defined according to the structure: wherein R represents C1-C2 n-alkyl; R1 is 2-methyl-1-propyl and R2 is hydrogen, or R1 and R2 taken together is a moiety having the formula —(CH2)n—, wherein n is 4 or 5, or compositions containing substantial concentrations of such mixtures, prepared according to novel processes: (a) extraction of a ground substantially dried fruit of one of the Piper species, Piper longum Linn or Piper peepuloides; (b) natural product-forming synthesis; or (c) synthetic product-forming synthesis. Also described are uses of the thus-formed products for augmenting, enhancing or imparting an aroma, taste, chemesthetic effect and/or antibacterial effect in or to a consumable material and/or in the oral cavity and/or on the mammalian epidermis.

Abstract: Described are mixtures of at least four of the alkadienamides defined according to the structure: wherein R represents C1-C2 n-alkyl; R1 is 2-methyl-1-propyl and R2 is hydrogen, or R1 and R2 taken together is a moiety having the formula —(CH2)n—, wherein n is 4 or 5, or compositions containing substantial concentrations of such mixtures, prepared according to novel processes: (a) extraction of a ground substantially dried fruit of one of the Piper species, Piper longum Linn or Piper peepuloides; (b) natural product-forming synthesis; or (c) synthetic product-forming synthesis. Also described are uses of the thus-formed products for augmenting, enhancing or imparting an aroma, taste, chemesthetic effect and/or antibacterial effect in or to a consumable material and/or in the oral cavity and/or on the mammalian epidermis.

Abstract: A method of designing a lithographic mask for use in lithographic processing of a substrate is disclosed. The lithographic processing comprises irradiating mask features of a lithographic mask using a predetermined irradiation configuration. In one aspect, the method comprises obtaining an initial design for the lithographic mask comprising a plurality of initial design features having an initial position. The method further comprises applying at least one shift to at least one initial design feature and deriving there from an altered design so as to compensate for shadowing effects when irradiating the substrate using a lithographic mask corresponding to the altered design in the predetermined irradiation configuration. Also disclosed herein are a corresponding design, a method of setting up lithographic processing, a system for designing a lithographic mask, a lithographic mask, and a method of manufacturing it.

Abstract: Throughput between personal computers and the Internet is increased by using inverse multiplexing over local loop telephone lines of different users. The different personal computers share the multiple intersubnetwork connections with each other, so that the efficiency of the use of the intersubnetwork connections is increased. Each of the computers is capable of receiving and/or transmitting inverse-multiplexed data signals over the same plurality of intersubnetwork connections. Preferably, at each computer, use is made of a separate connecting device locally coupled to the computer and an intersubnetwork connection and remotely coupled to one or more other such connecting devices. The connecting devices are placed in different housings, each having a regular connection with a local computer and a wireless transmission connection to corresponding connecting devices in neighboring housings.

Abstract: Bone repair composition and method of making the same, the bone repair composition being formed by firstly mixing a first aqueous calcium phosphate suspension with bone graft granules to form an intermediate mixture. The intermediate mixture is then mixed with a second aqueous calcium phosphate suspension, wherein the first aqueous calcium phosphate suspension contains a lower weight concentration of calcium phosphate than the second aqueous calcium phosphate suspension.