Patents by Inventor Jan Holmgren

Jan Holmgren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant systems for expression of the cholera B-sub-unit with the aid of foreign promoters and/or leader peptides
    Patent number: 6043057
    Abstract: Disclosed herein are procedures whereby with the aid of recombinant DNA methods, the expression of the binding subunit protein of cholera toxin (CTB) or derivatives thereof including hybrid gene fusion proteins to CTB has been brought under the control of a foreign (non-cholera toxin) promoter and/or the CTB protein or its derivatives being synthesized with a foreign rather than the natural leader peptide to facilitate translocation across cell membranes.
    Type: Grant
    Filed: April 22, 1997
    Date of Patent: March 28, 2000
    Assignee: Vitec Aktiebolag
    Inventors: Jan Holmgren, Joaquin Sanches Castillo
  • Hybrid molecules between heat-labile enterotoxin and cholera toxin B subunits
    Patent number: 6019973
    Abstract: Hybrid molecules between heat-labile enterotoxin B subunit (LTB) and cholera toxin B subunit (CTB) are disclosed. Such a hybrid molecule comprises an amino-acid sequence which is composed of the amino-acid sequence of mature CTB in which such amino-acid residues are substituted with the corresponding amino-acid residues of mature LTB which impart LTB-specific epitope characteristics to said immunogenic mature CTB, or vice versa. In addition, a structural gene coding for such a hybrid molecule, a plasmid containing such a structural gene, and an immunogenic protein comprising such a hybrid molecule and optionally an immunoreactive amino-acid sequence of a prokaryotic or eukaryotic cell or a virus, are disclosed. Disclosed is also a vaccine, e.g. against enterotoxin-induced illness, comprising such an immunogenic protein, and a method of preventing or treating enterotoxin-induced illness in an individual.
    Type: Grant
    Filed: January 5, 1998
    Date of Patent: February 1, 2000
    Inventors: Jan Holmgren, Michael R. Lebens
  • Recombinant systems for expression of cholera B-subunit with the aid of foreign promoters and/or leader peptides
    Patent number: 5834246
    Abstract: Disclosed herein are procedures whereby with the aid of recombinant DNA methods, the expression of the binding subunit protein of cholera toxin (CTB) or derivatives thereof including hybrid gene fusion proteins to CTB has been brought under the control of a foreign (non-cholera toxin) promoter and/or the CTB protein or its derivatives being synthesized with a foreign rather than the natural leader peptide to facilitate translocation across cell membranes.
    Type: Grant
    Filed: January 21, 1997
    Date of Patent: November 10, 1998
    Assignee: Vitec Aktiebolag
    Inventors: Jan Holmgren, Joaquin Sanches Castillo
  • Immunological tolerance-inducing agent
    Patent number: 5681571
    Abstract: An immunological tolerance-inducing agent comprising a mucosa-binding molecule linked to a specific tolerogen is disclosed. Further, a method of inducing immunological tolerance in an individual against a specific antigen, including hapten, which causes an unwanted immune response in said individual comprising administration by a mucosal route of an immunologically effective amount of an immunological tolerance-inducing agent of the invention to said individual, is described.
    Type: Grant
    Filed: January 19, 1994
    Date of Patent: October 28, 1997
    Assignee: Duotol AB
    Inventors: Jan Holmgren, Cecil Czerkinsky
  • Tumor antigen specific antibody
    Patent number: 5552293
    Abstract: A monoclonal antibody that reacts with the CA-242 antigen is provided. The antibody can be obtained by culturing the hybridoma cell line C242:II with the ECACC identification number 90012601, or an artificial or spontaneous mutant thereof. Cell lines producing the antibody are also provided. The antibody is useful for therapeutic and diagnostic purposes.
    Type: Grant
    Filed: May 8, 1995
    Date of Patent: September 3, 1996
    Assignee: Pharmacia Aktiebolag
    Inventors: Leif G. Lindholm, Jan Holmgren, Peter Lind
  • Peptides for use in induction of T cell activation against HIV-1
    Patent number: 5346989
    Abstract: Peptides corresponding to regions of the human immunodeficiency virus protein gp-120 are provided for eliciting T-cell activation.
    Type: Grant
    Filed: September 13, 1993
    Date of Patent: September 13, 1994
    Assignee: Syntello Vaccine Development KB
    Inventors: Anders Vahlne, Bo Svennerholm, Lars Rymo, Stig Jeansson, Peter Horal, Cecil Czerkinsky, Jan Holmgren
  • Recombinant systems for expression of cholera B-sub-unit with the aid of foreign promoters and/or leader peptides
    Patent number: 5268276
    Abstract: Disclosed herein are procedures whereby with the aid of recombinant DNA methods, the expression of the binding subunit protein of cholera toxin (CTB) or derivatives thereof including hybrid gene fusion proteins to CTB has been brought under the control of a foreign (non-cholera toxin) promoter and/or the CTB protein or its derivatives being synthesized with a foreign rather than the natural leader peptide to facilitate translocation across cell membranes.
    Type: Grant
    Filed: July 8, 1992
    Date of Patent: December 7, 1993
    Inventors: Jan Holmgren, Joaquin Sanches Castillo